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Autor:
Hu, Yuanyuan, Cronan, John E.
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Pimelic acid, a seven carbon α,ω-dicarboxylic acid (heptanedioic acid), is known to provide seven of the ten biotin carbon atoms including all those of the valeryl side chain. Distinct pimelate synthesis pathways were recently elucidated in Escheri
Autor:
Rohit Roy, Honglue Shi, Atul Rangadurai, Hashim M. Al-Hashimi, Hala Abou Assi, David A. Case, Daniel Herschlag, Joseph D. Yesselman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Biomolecules form dynamic ensembles of many inter-converting conformations which are key for understanding how they fold and function. However, determining ensembles is challenging because the information required to specify atomic structures for tho
Autor:
Jørgen Lock Andersen, Fabian Coscia, Ana R. Colaço, Marianne B. Løvendorf, Lili Niu, Beatrice Dyring-Andersen, Rachael A. Clark, Lone Skov, Sophia Doll, Michael Bzorek, Line Bruun Pilgaard Møller, Matthias Mann, Alberto Santos, Marcel B. M. Teunissen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Dyring-Andersen, B, Løvendorf, M B, Coscia, F, Santos, A, Møller, L B P, Colaço, A R, Niu, L, Bzorek, M, Doll, S, Andersen, J L, Clark, R A, Skov, L, Teunissen, M B M & Mann, M 2020, ' Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin ', Nature Communications, vol. 11, no. 1, 5587 . https://doi.org/10.1038/s41467-020-19383-8
Nature Communications
Nature communications, 11(1):5587. Nature Publishing Group
Dyring-Andersen, B, Løvendorf, M B, Coscia, F, Santos, A, Møller, L B P, Colaço, A R, Niu, L, Bzorek, M, Doll, S, Andersen, J L, Clark, R A, Skov, L, Teunissen, M B M & Mann, M 2020, ' Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin ', Nature Communications, vol. 11, no. 1, 5587 . https://doi.org/10.1038/s41467-020-19383-8
Nature Communications
Nature communications, 11(1):5587. Nature Publishing Group
Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent prot
Autor:
Ze-Lin Li, Ji-Hong Liu, Xin-Hong Zhu, Qiang-Long You, Xiaochun Bai, Neng-Yuan Hu, Yan Wang, Jian-Ming Yang, Jiang-Ping Xu, Shu-Ji Li, Zeng-Lin Jin, Tian-Ming Gao, Yifan Dai, Qian Wang, Xiao-Wen Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on n
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Folding of individual domains in large proteins during translation helps to avoid otherwise prevalent inter-domain misfolding. How folding intermediates observed in vitro for the majority of proteins relate to co-translational folding remains unclear
Autor:
Wenqin Wang, Qiao Xiao, Xiaoyan Gao, Haihai Wang, Yidong Zhu, Yongrui Wu, Yongcai Huang, Xing Huang, Brian A. Larkins, Xiaoli Xiang, Qiong Wang, Jiechen Wang, Changsheng Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
The mechanism that creates vitreous endosperm in the mature maize kernel is poorly understood. We identified Vitreous endosperm 1 (Ven1) as a major QTL influencing this process. Ven1 encodes β-carotene hydroxylase 3, an enzyme that modulates caroten
Autor:
Gabriela Matamoros, Chunhai Fan, Fangfang Chen, Hayam Mansour, Feng Li, Ana Sanchez, Guan A. Wang, Xiaoyu Xie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Combining experimental and simulation strategies to facilitate the design and operation of nucleic acid hybridization probes are highly important to both fundamental DNA nanotechnology and diverse biological/biomedical applications. Herein, we introd
Autor:
Akihisa Kato, Tohru Natsume, Tomohisa Hatta, Hideo Kusano, Shinobu Kitazume, Shungo Adachi, Yasushi Kawaguchi, Yuhei Maruzuru, Ryota Sato, Naoto Koyanagi, Jun Arii, Shuichi Kawano, Mizuki Watanabe, Kousuke Takeshima
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthog
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Non-ribosomal peptide synthetase (NRPS) enzymes form modular assembly-lines, wherein each module governs the incorporation of a specific monomer into a short peptide product. Modules are comprised of one or more key domains, including adenylation (A)
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Dearomative functionalization reactions represent an important strategy for the synthesis of valuable three-dimensional molecules from simple planar aromatics. Naphthalene is a challenging arene towards transition-metal-catalyzed dearomative difuncti