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Autor:
Geena Sompanya, Michelle Markman, Irene Hoxie, Devon A. Gregory, Nanami Kubota, Davida S. Smyth, Clayton A. Rushford, Anna Gao, Sherin Kannoly, Emma Teixeiro, Monica Trujillo, Fabrizio Spagnolo, Marc C. Johnson, Yue Guan, Reinier Suarez, Kristen Cheung, Maddie Graham, Caitlyn Guldenpfennig, Mark A. Daniels, Terri D. Lyddon, John J. Dennehy, Kaung Myat San
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Tracking SARS-CoV-2 genetic diversity is strongly indicated because diversifying selection may lead to the emergence of novel variants resistant to naturally acquired or vaccine-induced immunity. To monitor New York City (NYC) for the presence of nov
Autor:
Alejandro Gomez-Auli, Nicola Iovino, Michael Rauer, Dafne Ibarra-Morales, Mariana Schulte-Sasse, Francesco Cardamone, Leily Rabbani, Piergiuseppe Quarato, Fides Zenk, Germano Cecere
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development;
Autor:
Akihiko Okuda, Ayumu Suzuki, Kentaro Mochizuki, Kenjiro Shirane, Haruhiko Koseki, Kousuke Uranishi, Aaron B. Bogutz, Jafar Sharif, Matthew C. Lorincz, Sanne M. Janssen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the blastocyst, implicating alternative repressive pathways before implantation. Indeed, in embr
Autor:
Stephanie H. Nowotarski, Christopher P. Arnold, Chris Seidel, Jeffrey J. Lange, Analí Migueles Lozano, Alejandro Sánchez Alvarado, Frederick G. Mann, Julianna O. Haug
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Hox genes are highly conserved transcription factors renowned for their roles in the segmental patterning of the embryonic anterior-posterior (A/P) axis. We report functions for Hox genes in A/P tissue segmentation and transverse fission behavior und
Autor:
Jie Lin, Qirun Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
While most genes’ expression levels are proportional to cell volumes, some genes exhibit nonlinear scaling between their expression levels and cell volume. Therefore, their mRNA and protein concentrations change as the cell volume increases, which
Autor:
Megan McLaughlin, Medina Colic, Micaela Morgado, John G. Doench, Traver Hart, Peter C DeWeirdt, Eiru Kim, Audrey L Griffith, Nazanin Esmaeili Anvar, W. Frank Lenoir, Marissa N Feeley, Lori Bertolet, Merve Dede, Annabel K Sangree
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
CRISPR knockout fitness screens in cancer cell lines reveal many genes whose loss of function causes cell death or loss of fitness or, more rarely, the opposite phenotype of faster proliferation. Here we demonstrate a systematic approach to identify
Autor:
Megha Shah, Hyejin Esther Shin, Thomas J. Bateman, Yogesh Hooda, Trevor F. Moraes, Timothy Pham Ho, Jamie E. Fegan, Scott D. Gray-Owen, Greg Harris, Wangxue Chen, Chuxi Pan, Sang Kyun Ahn, Epshita A. Islam
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Nutrient acquisition systems are often crucial for pathogen growth and survival during infection, and represent attractive therapeutic targets. Here, we study the protein machinery required for heme uptake in the opportunistic pathogen Acinetobacter