Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Michael J. Kruhlak"'
Autor:
Michael J. Kruhlak, Oscar Fernandez-Capetillo, R. Daniel Camerini-Otero, Hua-Tang Chen, Yongping Yang, Bernardo Reina San Martin, Michel C. Nussenzweig, Lionel Feigenbaum, Simone Difilippantonio, Arkady Celeste, Galina V. Petukhova, André Nussenzweig, François Van Laethem, Shyam K. Sharan, Katia Manova, Michael Eckhaus
Publikováno v:
Nature Cell Biology. 7:675-685
Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate that Nbs1-null B cells are defective in the activation of ataxia-telangiectasia-mutated (A
Autor:
Oscar Fernandez-Capetillo, David W. Staudt, André Nussenzweig, Alicia Lee, Arkady Celeste, Michael J. Kruhlak, Robert F. Bonner, Duane R. Pilch, William M. Bonner
Publikováno v:
Nature Cell Biology. 5:675-679
Histone H2AX is rapidly phosphorylated in the chromatin micro-environment surrounding a DNA double-strand break (DSB). Although H2AX deficiency is not detrimental to life, H2AX is required for the accumulation of numerous essential proteins into irra