Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Harris, TB"'
Autor:
Ehret, Georg B., Munroe, Patricia B., Rice, Kenneth M., Bochud, Murielle, Johnson, Andrew D., Chasman, Daniel I., Smith, Albert V., Tobin, Martin D., Verwoert, Germaine C., Hwang, Shih-Jen, Pihur, Vasyl, Vollenweider, Peter, O'Reilly, Paul F., Amin, Najaf, Bragg-Gresham, Jennifer L., Teumer, Alexander, Glazer, Nicole L., Launer, Lenore, Zhao, Jing Hua, Aulchenko, Yurii, Heath, Simon, Sober, Siim, Parsa, Afshin, Luan, Jian'an, Arora, Pankaj, Dehghan, Abbas, Zhang, Feng, Lucas, Gavin, Hicks, Andrew A., Jackson, Anne U., Peden, John F., Tanaka, Toshiko, Wild, Sarah H., Rudan, Igor, Igl, Wilmar, Milaneschi, Yuri, Parker, Alex N., Fava, Cristiano, Chambers, John C., Fox, Ervin R., Kumari, Meena, Go, Min Jin, van der Harst, Pim, Kao, Wen Hong Linda, Sjögren, Marketa, Vinay, D. G., Alexander, Myriam, Tabara, Yasuharu, Shaw-Hawkins, Sue, Whincup, Peter H., Liu, Yongmei, Shi, Gang, Kuusisto, Johanna, Tayo, Bamidele, Seielstad, Mark, Sim, Xueling, Hoang Nguyen, Khanh-Dung, Lehtimäki, Terho, Matullo, Giuseppe, Wu, Ying, Gaunt, Tom R., Charlotte Onland-Moret, N., Cooper, Matthew N., Platou, Carl G. P., Org, Elin, Hardy, Rebecca, Dahgam, Santosh, Palmen, Jutta, Vitart, Veronique, Braund, Peter S., Kuznetsova, Tatiana, Uiterwaal, Cuno S. P. M., Adeyemo, Adebowale, Palmas, Walter, Campbell, Harry, Ludwig, Barbara, Tomaszewski, Maciej, Tzoulaki, Ioanna, Palmer, Nicholette D., Aspelund, Thor, Garcia, Melissa, Chang, Yen-Pei C., O'Connell, Jeffrey R., Steinle, Nanette I., Grobbee, Diederick E., Arking, Dan E., Kardia, Sharon L., Morrison, Alanna C., Hernandez, Dena, Najjar, Samer, McArdle, Wendy L., Hadley, David, Brown, Morris J., Connell, John M., Hingorani, Aroon D., Day, Ian N. M., Lawlor, Debbie A., Beilby, John P., Lawrence, Robert W., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Dreisbach, Albert W., Li, Yali, Hunter Young, J., Bis, Joshua C., Kähönen, Mika, Viikari, Jorma, Adair, Linda S., Lee, Nanette R., Chen, Ming-Huei, Olden, Matthias, Pattaro, Cristian, Bolton, Judith A Hoffman, Köttgen, Anna, Bergmann, Sven, Mooser, Vincent, Chaturvedi, Nish, Frayling, Timothy M., Islam, Muhammad, Jafar, Tazeen H., Erdmann, Jeanette, Kulkarni, Smita R., Bornstein, Stefan R., Grässler, Jürgen, Groop, Leif, Voight, Benjamin F., Kettunen, Johannes, Howard, Philip, Taylor, Andrew, Guarrera, Simonetta, Ricceri, Fulvio, Emilsson, Valur, Plump, Andrew, Barroso, Inês, Khaw, Kay-Tee, Weder, Alan B., Hunt, Steven C., Sun, Yan V., Bergman, Richard N., Collins, Francis S., Bonnycastle, Lori L., Scott, Laura J., Stringham, Heather M., Peltonen, Leena, Perola, Markus, Vartiainen, Erkki, Brand, Stefan-Martin, Staessen, Jan A., Wang, Thomas J., Burton, Paul R., Artigas, Maria Soler, Dong, Yanbin, Snieder, Harold, Wang, Xiaoling, Zhu, Haidong, Lohman, Kurt K., Rudock, Megan E., Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Doumatey, Ayo, Shriner, Daniel, Veldre, Gudrun, Viigimaa, Margus, Kinra, Sanjay, Prabhakaran, Dorairaj, Tripathy, Vikal, Langefeld, Carl D., Rosengren, Annika, Thelle, Dag S., Corsi, Anna Maria, Singleton, Andrew, Forrester, Terrence, Hilton, Gina, McKenzie, Colin A., Salako, Tunde, Iwai, Naoharu, Kita, Yoshikuni, Ogihara, Toshio, Ohkubo, Takayoshi, Okamura, Tomonori, Ueshima, Hirotsugu, Umemura, Satoshi, Eyheramendy, Susana, Meitinger, Thomas, Wichmann, H. -Erich, Cho, Yoon Shin, Kim, Hyung-Lae, Lee, Jong-Young, Scott, James, Sehmi, Joban S., Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Smith, George Davey, Wong, Andrew, Narisu, Narisu, Stančáková, Alena, Raffel, Leslie J., Yao, Jie, Kathiresan, Sekar, O'Donnell, Christopher J., Schwartz, Stephen M., Arfan Ikram, M., Longstreth Jr. , W. T., Mosley, Thomas H., Seshadri, Sudha, Shrine, Nick R. G., Wain, Louise V., Morken, Mario A., Swift, Amy J., Laitinen, Jaana, Prokopenko, Inga, Zitting, Paavo, Cooper, Jackie A., Humphries, Steve E., Danesh, John, Rasheed, Asif, Goel, Anuj, Hamsten, Anders, Watkins, Hugh, Bakker, Stephan J. L., van Gilst, Wiek H., Janipalli, Charles S., Radha Mani, K., Yajnik, Chittaranjan S., Hofman, Albert, Mattace-Raso, Francesco U. S., Oostra, Ben A., Demirkan, Ayse, Isaacs, Aaron, Rivadeneira, Fernando, Lakatta, Edward G., Orru, Marco, Scuteri, Angelo, Ala-Korpela, Mika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Soininen, Pasi, Tukiainen, Taru, Würtz, Peter, Twee-HeeOng, Rick, Dörr, Marcus, Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Zelenika, Diana, Deloukas, Panos, Mangino, Massimo, Spector, Tim D., Zhai, Guangju, Meschia, James F., Nalls, Michael A., Sharma, Pankaj, Terzic, Janos, Kranthi Kumar, M. V., Denniff, Matthew, Zukowska-Szczechowska, Ewa, Wagenknecht, Lynne E., Fowkes, F. Gerald R., Charchar, Fadi J., Schwarz, Peter E. H., Hayward, Caroline, Guo, Xiuqing, Rotimi, Charles, Bots, Michiel L., Brand, Eva, Samani, Nilesh J., Polasek, Ozren, Talmud, Philippa J., Nyberg, Fredrik, Kuh, Diana, Laan, Maris, Hveem, Kristian, Palmer, Lyle J., van der Schouw, Yvonne T., Casas, Juan P., Mohlke, Karen L., Vineis, Paolo, Raitakari, Olli, Ganesh, Santhi K., Wong, Tien Y., Shyong Tai, E., Cooper, Richard S., Laakso, Markku, Rao, Dabeeru C., Harris, Tamara B., Morris, Richard W., Dominiczak, Anna F., Kivimaki, Mika, Marmot, Michael G., Miki, Tetsuro, Saleheen, Danish, Chandak, Giriraj R., Coresh, Josef, Navis, Gerjan, Salomaa, Veikko, Han, Bok-Ghee, Zhu, Xiaofeng, Kooner, Jaspal S., Melander, Olle, Ridker, Paul M., Bandinelli, Stefania, Gyllensten, Ulf B., Wright, Alan F., Wilson, James F., Ferrucci, Luigi, Farrall, Martin, Tuomilehto, Jaakko, Pramstaller, Peter P., Elosua, Roberto, Soranzo, Nicole, Sijbrands, Eric J. G., Altshuler, David, Loos, Ruth J. F., Shuldiner, Alan R., Gieger, Christian, Meneton, Pierre, Uitterlinden, Andre G., Wareham, Nicholas J., Gudnason, Vilmundur, Rotter, Jerome I., Rettig, Rainer, Uda, Manuela, Strachan, David P., Witteman, Jacqueline C. M., Hartikainen, Anna-Liisa, Beckmann, Jacques S., Boerwinkle, Eric, Vasan, Ramachandran S., Boehnke, Michael, Larson, Martin G., Järvelin, Marjo-Riitta, Psaty, Bruce M., Abecasis, Gonçalo R., Chakravarti, Aravinda, Elliott, Paul, van Duijn, Cornelia M., Newton-Cheh, Christopher, Levy, Daniel, Caulfield, Mark J., Johnson, Toby, Tang H, Knowles J, Hlatky M, Fortmann S, Assimes TL, Quertermous T, Go A, Iribarren C, Absher D, Risch N, Meyers R, Sidney S, Ziegler A, Schillert A, Bickel C, Sinning C, Rupprecht HJ, Lackner K, Wild P, Schnabel R, Blankenberg S, Zeller T, Münzel T, Perret C, Cambien F, Tiret L, Nicaud V, Proust C, Dehghan A, Hofman A, Uitterlinden A, van Duijn C, Levy D, Whitteman J, Cupples LA, Demissie-Banjaw S, Ramachandran V, Smith A, Gudnason V, Boerwinkle E, Folsom A, Morrison A, Psaty BM, Chen IY, Rotter JI, Bis J, Volcik K, Rice K, Taylor KD, Marciante K, Smith N, Glazer N, Heckbert S, Harris T, Lumley T, Kong A, Thorleifsson G, Thorgeirsson G, Holm H, Gulcher JR, Stefansson K, Andersen K, Gretarsdottir S, Thorsteinsdottir U, Preuss M, Schreiber S, Meitinger T, König IR, Lieb W, Hengstenberg C, Schunkert H, Erdmann J, Fisher M, Grosshennig A, Medack A, Stark K, Linsel-Nitschke P, Bruse P, Aherrahrou Z, Peters A, Loley C, Willenborg C, Nahrstedt J, Freyer J, Gulde S, Doering A, Meisinger C, Wichmann HE, Klopp N, Illig T, Meinitzer A, Tomaschitz A, Halperin E, Dobnig H, Scharnagl H, Kleber M, Laaksonen R, Pilz S, Grammer TB, Stojakovic T, Renner W, März W, Böhm BO, Winkelmann BR, Winkler K, Hoffmann M, O'Donnell CJ, Voight BF, Altshuler D, Siscovick DS, Musunuru K, Peltonen L, Barbalic M, Melander O, Elosua R, Kathiresan S, Schwartz SM, Salomaa V, Guiducci C, Burtt N, Gabriel SB, Stewart AF, Wells GA, Chen L, Jarinova O, Roberts R, McPherson R, Dandona S, Pichard AD, Rader DJ, Devaney J, Lindsay JM, Kent KM, Qu L, Satler L, Burnett MS, Li M, Reilly MP, Wilensky R, Waksman R, Epstein S, Mattha W, Knouf CW, Waterworth DM, Hakonarson HH, Walker M, Mooser V, Hall AS, Balmforth AJ, Wright BJ, Nelson C, Thompson JR, Samani NJ, Braund PS, Ball SG, Smith NL, Felix JF, Morrison AC, Demissie S, Glazer NL, Loehr LR, Rosamond WD, Rivadeneira F, Bis JC, Folsom AR, Benjamin E, Aulchenko YS, Haritunians T, Couper D, Murabito J, Wang YA, Stricker B, Gottdiener JS, Chang PP, Wang TJ, Rice KM, Heckbert SR, Fox ER, Uitterlinden AG, Willerson JT, van Duijn CM, Witteman JC, Vasan RS, Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson A, Teumer A, Paré G, Atkinson EJ, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Struchalin M, Cavalieri M, Singleton A, Giallauria, Francesco, Metter J, de Boer J, Siscovick D, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turne ST, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS, Vasan R, Felix SB, Watzinger N, Larson MG, Homuth G, Aragam J, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Deckers JW, Stritzke J, Lackner KJ, Ingelsson E, Kullo I, Haerting J, Stricker BH, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Arnett D, Blettner M, Friedrich N, Benjamin EJ, Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ, Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic T, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Munroe PB, Nordfors L, Penninx BW, Perucha E, Pouta A, Roderick PJ, Ruokonen A, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Abecasis GR, Lightstone L, Scott J, Navis G, Elliot P, Kooner JS.
Publikováno v:
Nature, Vol. 11 (2011) P. 103
Nature
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Nature; Vol 478
Nature, 478(7367), 103-109. Nature Publishing Group
Nature, vol. 478, no. 7367, pp. 103-109
NATURE
Artículos CONICYT
CONICYT Chile
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Nature, 2011, 478 (7367), pp.103-109. ⟨10.1038/nature10405⟩
Ehret, G B, Munroe, P B, Rice, K M, Bochud, M, Johnson, A D, Chasman, D I, Smith, A V, Tobin, M D, Verwoert, G C, Hwang, S-J, Pihur, V, Vollenweider, P, O'Reilly, P F, Amin, N, Bragg-Gresham, J L, Teumer, A, Glazer, N L, Launer, L, Zhao, J H, Aulchenko, Y, Heath, S, Sõber, S, Parsa, A, Luan, J, Arora, P, Dehghan, A, Zhang, F, Lucas, G, Hicks, A A, Jackson, A U, Peden, J F, Tanaka, T, Wild, S H, Rudan, I, Igl, W, Milaneschi, Y, Parker, A N, Fava, C, Chambers, J C, Fox, E R, Kumari, M, Go, M J, van der Harst, P, Kao, W H L, Sjögren, M, Vitart, V, Campbell, H, Hayward, C & Wright, A F & Wilson, J F 2011, ' Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk ', Nature, vol. 478, no. 7367, pp. 103-109 . https://doi.org/10.1038/nature10405
Nature
BASE-Bielefeld Academic Search Engine
Nature; Vol 478
Nature, 478(7367), 103-109. Nature Publishing Group
Nature, vol. 478, no. 7367, pp. 103-109
NATURE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Nature, 2011, 478 (7367), pp.103-109. ⟨10.1038/nature10405⟩
Ehret, G B, Munroe, P B, Rice, K M, Bochud, M, Johnson, A D, Chasman, D I, Smith, A V, Tobin, M D, Verwoert, G C, Hwang, S-J, Pihur, V, Vollenweider, P, O'Reilly, P F, Amin, N, Bragg-Gresham, J L, Teumer, A, Glazer, N L, Launer, L, Zhao, J H, Aulchenko, Y, Heath, S, Sõber, S, Parsa, A, Luan, J, Arora, P, Dehghan, A, Zhang, F, Lucas, G, Hicks, A A, Jackson, A U, Peden, J F, Tanaka, T, Wild, S H, Rudan, I, Igl, W, Milaneschi, Y, Parker, A N, Fava, C, Chambers, J C, Fox, E R, Kumari, M, Go, M J, van der Harst, P, Kao, W H L, Sjögren, M, Vitart, V, Campbell, H, Hayward, C & Wright, A F & Wilson, J F 2011, ' Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk ', Nature, vol. 478, no. 7367, pp. 103-109 . https://doi.org/10.1038/nature10405
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure).
Autor:
Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Medina-Gomez C; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Lo KS; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Kjaer TR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark., Fine RS; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA., Lu Y; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA., Highland HM; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.; Human Genetics Center, The University of Texas School of Public Health, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Rüeger S; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Thorleifsson G; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland., Justice AE; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Lamparter D; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.; Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland., Stirrups KE; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK., Turcot V; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany., Esko T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Karaderi T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.; McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, Missouri 63108, USA., Masca NG; Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Ng MC; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Mudgal P; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Rivas MA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Nuffield Department of Clinical Medicine, Oxford OX3 7BN, UK., Vedantam S; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Guo X; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Aben KK; Netherlands Comprehensive Cancer Organisation, Utrecht, 3501 DB, The Netherlands.; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Alam DS; Centre for Control of Chronic Diseases (CCCD), Dhaka, 1212, Bangladesh., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany., Allin KH; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Allison M; Department of Family Medicine &Public Health, University of California, San Diego, La Jolla, California 92093, USA., Amouyel P; INSERM U1167, Lille, F-59019, France.; Institut Pasteur de Lille, U1167, Lille, F-59019, France.; Universite de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, F-59019, France., Appel EV; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Arveiler D; Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, F-67085, France.; Department of Public Health, University Hospital of Strasbourg, Strasbourg, 67081, France., Asselbergs FW; Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Auer PL; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA., Balkau B; INSERM U1018, Centre de recherche en Épidemiologie et Sante des Populations (CESP), Villejuif, France., Banas B; Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany., Bang LE; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Benn M; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Bergmann S; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.; Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Blüher M; IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.; University of Leipzig, Department of Medicine, Leipzig, 04103, Germany., Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Boerwinkle E; School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Bowden DW; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, 7100, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark., Breen G; MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London &NIHR Biomedical Research Centre for Mental Health at the Maudsley, London, SE5 8AF, UK., Brilliant MH; Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA., Broer L; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Burt AA; Department of Medicine, University of Washington, Seattle, Washington 98195, USA., Butterworth AS; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK., Carey DJ; The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK., Chambers JC; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chasman DI; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Chen YI; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Chowdhury R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Christensen C; Medical Department, Lillebaelt Hospital, Vejle, 7100, Denmark., Chu AY; Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.; NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA., Cocca M; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, 34100, Italy., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK., Corley J; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Galbany JC; Department of Human Genetics, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Cox AJ; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.; Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia., Cuellar-Partida G; Diamantina Institute, University of Qeensland, Brisbane, Queensland, 4072, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Danesh J; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., de Bakker PI; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., de Denus S; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., de Groot MC; Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology &Clinical Pharmacology, Utrecht University, Utrecht, 3508 TB, The Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece., Demerath EW; Division of Epidemiology &Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA., den Hollander AI; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Dennis JG; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Di Angelantonio E; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB1 8RN, UK., Drenos F; Institute of Cardiovascular Science, University College London, London WC1E 6JF, UK.; MRC Integrative Epidemiology Unit, School of Social &Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Du M; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, Washington 98109, USA.; Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, New York 10017, USA., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Ebeling T; Department of Medicine, Oulu University Hospital, Oulu, 90029, Finland.; Research Unit of Internal Medicine, University of Oulu, Oulu, FI-90014, Finland., Edwards TL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA., Ellinor PT; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA., Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA., Feng S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Ferrannini E; CNR Institute of Clinical Physiology, Pisa, Italy.; Department of Clinical &Experimental Medicine, University of Pisa, Pisa, Italy., Ferrario MM; Research Center on Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, 21100, Italy., Ferrieres J; Toulouse University School of Medicine, Toulouse, TSA 50032 31059, France., Florez JC; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.; Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA., Ford I; University of Glasgow, Glasgow G12 8QQ, UK., Fornage M; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, 901 87, Sweden., Frikke-Schmidt R; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Galesloot TE; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Gan W; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gandin I; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy., Gasparini P; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.; Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar., Giedraitis V; Geriatrics, Department of Public Health, Uppsala University, Uppsala, 751 85, Sweden., Giri A; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA., Girotto G; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.; Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Gordon-Larsen P; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Grove ML; School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.; Icelandic Heart Association, Kopavogur, 201, Iceland., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Harris KM; Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.; Department of Sociology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Hayward C; MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., He L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA.; Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany., Heikkilä K; Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland., Helgeland Ø; Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway., Hernesniemi J; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, 33521, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Hewitt AW; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, 3002, Australia.; Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia.; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, 7000, Australia., Hocking LJ; Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.; Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, AB25 2ZD, UK., Hollensted M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Holmen OL; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway., Hovingh GK; AMC, Department of Vascular Medicine, Amsterdam, 1105 AZ, The Netherlands., Howson JM; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Hoyng CB; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Huang PL; Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Hveem K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7600, Norway., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Neurology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Radiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Jansson JH; Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.; Research Unit Skellefteå, Skellefteå, SE-93141, Sweden., Jarvik GP; Department of Medicine, University of Washington, Seattle, Washington 98195, USA.; Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA., Jensen GB; The Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, 2000, Denmark., Jhun MA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Jia Y; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Jiang X; Department of Preventive Medicine, Keck School of Medicine of the University of California, Los Angeles, California 90089, USA.; USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA., Johansson S; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5021, Norway., Jørgensen ME; National Institute of Public Health, University of Southern Denmark, Copenhagen, 1353, Denmark.; Steno Diabetes Center, Gentofte, 2820, Denmark., Jørgensen T; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Aalborg University, Aalborg, DK-9000, Denmark.; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark., Jousilahti P; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.; The Interuniversity Cardiology Institute of the Netherlands, Utrecht, 2333, The Netherlands., Kahali B; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA., Kahn RS; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands., Kähönen M; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, 33014, Finland., Kamstrup PR; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Kaprio J; Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Karaleftheri M; Echinos Medical Centre, Echinos, Greece., Kardia SL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Kee F; UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast BT12 6BJ, UK., Keeman R; Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands., Kiemeney LA; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Kitajima H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kluivers KB; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Kocher T; Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, 17475, Germany., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Kontto J; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Kooner JS; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK.; National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kovacs P; IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany., Kriebel J; German Center for Diabetes Research, München-Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, D-85764, Germany., Kuivaniemi H; The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.; Department of Psychiatry, and Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa., Küry S; CHU Nantes, Service de Génétique Médicale, Nantes, 44093, France., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., La Bianca M; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Institute of Biomedicine &Physiology, University of Eastern Finland, Kuopio, 70210, Finland., Lange EM; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Langefeld CD; Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Larson EB; Department of Medicine, University of Washington, Seattle, Washington 98195, USA.; Group Health Research Institute, Seattle, Washington 98101, USA.; Department of Health Services, University of Washington, Seattle, Washington 98101, USA., Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Lewis CE; Division of Preventive Medicine University of Alabama at Birmingham, Birmingham, Alabama 35205, USA., Li H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Li J; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Lin H; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Lin LA; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA., Lin X; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Lind L; Uppsala University, Uppsala, 75185, Sweden., Lindström J; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Linneberg A; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.; Department of Experimental Medicine, Rigshospitalet, Copenhagen, DK-2200, Denmark., Liu Y; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Liu Y; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Lophatananon A; Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Lubitz SA; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, 33014, Finland., Mackey DA; Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia., Madden PA; Department of Psychiatry, Washington University, Saint Louis, Missouri 63110, USA., Manning AK; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA.; Department of Medicine, Harvard University Medical School, Boston, Massachusetts 02115, USA., Männistö S; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Marenne G; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Marten J; MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Mazul AL; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Meidtner K; German Center for Diabetes Research, München-Neuherberg, 85764, Germany.; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Mitchell P; Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, 2022, Australia., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Morgan A; Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy., Morris AD; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.; Department of Medicine I, Ludwig-Maximilians-Universität, Munich, 81377, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, 80802, Germany., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Nauck M; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany., Nelson CP; Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, 33521, Finland., Njølstad PR; Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., O'Connel JR; Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Oksa H; Department of Medicine, Tampere University Hospital, Tampere, 33521, Finland., Loohuis LM; Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA., Ophoff RA; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.; Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford OX3 7LE, UK., Packard CJ; University of Glasgow, Glasgow G12 8QQ, UK., Padmanabhan S; University of Glasgow, Glasgow G12 8QQ, UK., Palmer CN; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Pasterkamp G; Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.; Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Patel AP; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA.; Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Pattie A; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Peissig PL; Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA., Peloso GM; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts 02141, USA., Pennell CE; School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia., Perola M; National Institute for Health and Welfare, Helsinki, FI-00271, Finland.; University of Helsinki, Institute for Molecular Medicine (FIMM) and Diabetes and Obesity Research Program, Helsinki, FI00014, Finland.; University of Tartu, Estonian Genome Center, Tartu, Estonia, Tartu, 51010, Estonia., Perry JA; Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Person TN; Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA., Pirie A; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Polasek O; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.; School of Medicine, University of Split, Split, 21000, Croatia., Posthuma D; Center for Neurogenomics and Cognitive Research, Department Complex Trait Genetics, VU University, Amsterdam, 1081 HV, The Netherlands.; Neuroscience Campus Amsterdam, Department Clinical Genetics, VU Medical Center, Amsterdam, 1081 HV, The Netherlands., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70210, Finland., Reilly DF; MRL, Merck &Co., Inc., Genetics and Pharmacogenomics, Boston, Massachusetts 02115, USA., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.; Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.; Department of Biobank Research, Umeå University, Umeå, SE-90187, Sweden., Ridker PM; Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Rioux JD; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., Robertson N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Rolandsson O; Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.; Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, 90185, Sweden., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK., Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Saleheen D; Centre for Non-Communicable Diseases, Karachi, Pakistan.; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Salomaa V; National Institute for Health and Welfare, Helsinki, FI-00271, Finland., Samani NJ; Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Sandow K; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Sapkota Y; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia., Sattar N; University of Glasgow, Glasgow G12 8QQ, UK., Schmidt MK; Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands., Schreiner PJ; Division of Epidemiology &Community Health University of Minnesota, Minneapolis, Minnesota 55454, USA., Schulze MB; German Center for Diabetes Research, München-Neuherberg, 85764, Germany.; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Segura-Lepe MP; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK., Shah S; Duke University, Durham, North Carolina 27703, USA., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Sivapalaratnam S; Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Departement of Haematology, University of Cambridge, Cambridge CB2 OPT, UK.; Department of Vascular Medicine, AMC, Amsterdam, 1105 AZ, The Netherlands., Small KS; Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK., Smith AV; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.; Icelandic Heart Association, Kopavogur, 201, Iceland., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Southam L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK., Speliotes EK; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK., Steinthorsdottir V; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Stumvoll M; IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.; University of Leipzig, Department of Medicine, Leipzig, 04103, Germany., Surendran P; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., 't Hart LM; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands.; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands., Tansey KE; College of Biomedical and Life Sciences, Cardiff University, Cardiff, CF14 4EP, UK.; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Tardif JC; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., Taylor KD; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Thorsteinsdottir U; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Thuesen BH; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark., Tönjes A; Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, 04103, Germany., Tromp G; The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Western Cape, 7505, South Africa., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333, The Netherlands., Tsafantakis E; Anogia Medical Centre, Anogia, Greece., Tuomilehto J; National Institute for Health and Welfare, Helsinki, FI-00271, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, 3500, Austria.; Dasman Diabetes Institute, Dasman, 15462, Kuwait.; Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Tybjaerg-Hansen A; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Tyrer JP; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Uher R; Department of Psychiatry, Dalhousie University, Halifax B3H 4R2, Canada., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., van der Laan SW; Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands., Van Der Leij AR; University of Amsterdam, Department of Brain &Cognition, Amsterdam, 1018 WS, The Netherlands., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., van Schoor NM; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands., van Setten J; Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Varbo A; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden., Varma R; USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA., Edwards DR; Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA., Vermeulen SH; Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Vestergaard H; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark., Vitart V; MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Vogt TF; MRL, Merck &Co., Inc., Cardiometabolic Disease, Kenilworth, New Jersey 07033, USA., Vozzi D; Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar., Walker M; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle NE2 4HH, UK., Wang F; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Wang CA; School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Wang Y; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine &Dentistry, Queen Mary University, London EC1M 6BQ, UK., Wessel J; Departments of Epidemiology &Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health &School of Medicine, Indiana University, Indiana 46202, USA., Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA., Witte DR; Danish Diabetes Academy, Odense, 5000, Denmark.; Department of Public Health, Aarhus University, Aarhus, 8000, Denmark., Woods MO; Memorial University, Faculty of Medicine, Discipline of Genetics, St. John's, Newfoundland A1B 3V6, Canada., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Yao J; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Yao P; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Yerges-Armstrong LM; Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; GlaxoSmithKlein, King of Prussia, Pennsylvania 19406, USA., Young R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; University of Glasgow, Glasgow G12 8QQ, UK., Zeggini E; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Zhan X; Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA., Zhang W; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Zhao W; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA., Zheng H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China., Zhou W; 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Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Stefansson K; deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Borecki IB; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA., Liu DJ; Department of Public Health Sciences, Institute for Personalized Medicine, the Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA., North KE; Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, North Carolina 27514, USA., Heard-Costa NL; NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Pers TH; 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The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA.; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, New York 10069, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK., Hirschhorn JN; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Lettre G; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada.
Publikováno v:
Nature [Nature] 2017 Feb 09; Vol. 542 (7640), pp. 186-190. Date of Electronic Publication: 2017 Feb 01.
Autor:
Okbay A; Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands., Beauchamp JP; Department of Economics, Harvard University, Cambridge, Massachusetts 02138, USA., Fontana MA; Center for Economic and Social Research, University of Southern California, Los Angeles, California 90089-3332, USA., Lee JJ; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA., Pers TH; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 2116, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen 2100, Denmark.; Statens Serum Institut, Department of Epidemiology Research, Copenhagen 2300, Denmark., Rietveld CA; Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands., Turley P; Department of Economics, Harvard University, Cambridge, Massachusetts 02138, USA., Chen GB; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Emilsson V; Icelandic Heart Association, Kopavogur 201, Iceland.; Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavík 107, Iceland., Meddens SF; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands.; Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands.; Amsterdam Business School, University of Amsterdam, Amsterdam, 1018 TV, The Netherlands., Oskarsson S; Department of Government, Uppsala University, Uppsala 751 20, Sweden., Pickrell JK; New York Genome Center, New York, New York 10013, USA., Thom K; Department of Economics, New York University, New York, New York 10012, USA., Timshel P; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark Lyngby 2800, Denmark., de Vlaming R; Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, 3062 PA, The Netherlands., Abdellaoui A; Department of Biological Psychology, VU University Amsterdam, Amsterdam, 1081 BT, The Netherlands., Ahluwalia TS; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen 2100, Denmark.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark.; Steno Diabetes Center, Gentofte 2820, Denmark., Bacelis J; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg 416 85, Sweden., Baumbach C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Bjornsdottir G; deCODE Genetics/Amgen Inc., Reykjavik 101, Iceland., Brandsma JH; Department of Cell Biology, Erasmus Medical Center Rotterdam, 3015 CN, The Netherlands., Pina Concas M; Istituto di Ricerca Genetica e Biomedica U.O.S. di Sassari, National Research Council of Italy, Sassari 07100, Italy., Derringer J; Psychology, University of Illinois, Champaign, Illinois 61820, USA., Furlotte NA; 23andMe, Inc., Mountain View, California 94041, USA., Galesloot TE; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands., Girotto G; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34100, Italy., Gupta R; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland., Hall LM; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Hofer E; Department of Neurology, General Hospital and Medical University Graz, Graz 8036, Austria.; Institute for Medical Informatics, Statistics and Documentation, General Hospital and Medical University Graz, Graz 8036, Austria., Horikoshi M; Oxford Centre for Diabetes, Endocrinology &Metabolism, University of Oxford, Oxford OX3 7LE, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Huffman JE; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Kaasik K; Institute of Behavioural Sciences, University of Helsinki, 00014 Helsinki, Finland., Kalafati IP; Nutrition and Dietetics, Health Science and Education, Harokopio University, Athens 17671, Greece., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden., Kong A; deCODE Genetics/Amgen Inc., Reykjavik 101, Iceland., Lahti J; Institute of Behavioural Sciences, University of Helsinki, 00014 Helsinki, Finland.; Folkhälsan Research Centre, 00014 Helsingfors, Finland., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands., deLeeuw C; Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands.; Institute for Computing and Information Sciences, Radboud University Nijmegen, Nijmegen, 6525 EC, The Netherlands., Lind PA; Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia., Lindgren KO; Department of Government, Uppsala University, Uppsala 751 20, Sweden., Liu T; Lifespan Psychology, Max Planck Institute for Human Development, Berlin 14195, Germany., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; NIHR Biomedical Research Centre, Guy's and St. Thomas' Foundation Trust, London SE1 7EH, UK., Marten J; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Miller MB; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Oldmeadow C; Public Health Stream, Hunter Medical Research Institute, New Lambton, NSW 2305, Australia.; Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 2300, Australia., Payton A; Centre for Integrated Genomic Medical Research, Institute of Population Health, The University of Manchester, Manchester M13 9PT, UK.; Human Communication and Deafness, School of Psychological Sciences, The University of Manchester, Manchester M13 9PL, UK., Pervjakova N; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Department of Health, THL-National Institute for Health and Welfare, 00271 Helsinki, Finland., Peyrot WJ; Psychiatry, VU University Medical Center &GGZ inGeest, Amsterdam, 1081 HL, The Netherlands., Qian Y; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Raitakari O; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20521 Turku, Finland., Rueedi R; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland.; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland., Salvi E; Department Of Health Sciences, University of Milan, Milano 20142, Italy., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen 45147, Germany., Schraut KE; Centre for Global Health Research, The Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK., Shi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9780, USA., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Poot RA; Department of Cell Biology, Erasmus Medical Center Rotterdam, 3015 CN, The Netherlands., St Pourcain B; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.; School of Oral and Dental Sciences, University of Bristol, Bristol BS1 2LY, UK., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Thorleifsson G; deCODE Genetics/Amgen Inc., Reykjavik 101, Iceland., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands., Vuckovic D; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34100, Italy., Wellmann J; Institute of Epidemiology and Social Medicine, University of Münster, Münster 48149, Germany., Westra HJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02115, USA., Yang J; 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The University of Queensland Diamantina Institute, The Translational Research Institute, Brisbane, QLD 4102, Australia., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48109, USA., Feitosa MF; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri 63018, USA., Forstner AJ; Institute of Human Genetics, University of Bonn, Bonn 53127, Germany.; Department of Genomics, Life and Brain Center, University of Bonn, Bonn 53127, Germany., Gandin I; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34100, Italy., Gunnarsson B; deCODE Genetics/Amgen Inc., Reykjavik 101, Iceland., Halldórsson BV; deCODE Genetics/Amgen Inc., Reykjavik 101, Iceland.; Institute of Biomedical and Neural Engineering, School of Science and Engineering, Reykjavik University, Reykjavik 101, Iceland., Harris TB; Laboratory of Epidemiology, Demography, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892-9205, USA., Heath AC; 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Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Marques-Vidal P; Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne 1011, Switzerland., Meddens GA; Tema BV, Hoofddorp, 2131 HE, The Netherlands., McMahon G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Meisinger C; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Milaneschi Y; Psychiatry, VU University Medical Center &GGZ inGeest, Amsterdam, 1081 HL, The Netherlands., Milani L; 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Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34100, Italy.; Medical Genetics, Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste 34100, Italy.; Sidra, Experimental Genetics Division, Sidra, Doha 26999, Qatar., Gejman PV; Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, Illinois 60201-3137, USA.; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald 17475, Germany.; Department of Psychiatry and Psychotherapy, HELIOS-Hospital Stralsund, Stralsund 18437, Germany., Gratten J; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Groenen PJ; Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands., Gudnason V; 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Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.; Department of Health, THL-National Institute for Health and Welfare, 00271 Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland., Kardia SL; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Lehtimäki T; Fimlab Laboratories, 33520 Tampere, Finland.; Department of Clinical Chemistry, University of Tampere, School of Medicine, 33014 Tampere, Finland., Lehrer SF; Economics, NYU Shanghai, 200122 Pudong, China.; Policy Studies, Queen's University, Kingston, Ontario K7L 3N6, Canada., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden., Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia., McGue M; Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Pendleton N; Centre for Clinical and Cognitive Neuroscience, Institute Brain Behaviour and Mental Health, Salford Royal Hospital, Manchester M6 8HD, UK.; Manchester Institute for Collaborative Research in Ageing, University of Manchester, Manchester M13 9PL, UK., Penninx BW; Psychiatry, VU University Medical Center &GGZ inGeest, Amsterdam, 1081 HL, The Netherlands., Perola M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Department of Health, THL-National Institute for Health and Welfare, 00271 Helsinki, Finland., Pirastu N; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste 34100, Italy., Pirastu M; Istituto di Ricerca Genetica e Biomedica U.O.S. di Sassari, National Research Council of Italy, Sassari 07100, Italy., Polasek O; Centre for Global Health Research, The Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.; Faculty of Medicine, University of Split, Split 21000, Croatia., Posthuma D; Department of Complex Trait Genetics, VU University, Center for Neurogenomics and Cognitive Research, Amsterdam, 1081 HV, The Netherlands.; Department of Clinical Genetics, VU Medical Centre, Amsterdam, 1081 HV, The Netherlands., Power C; Population, Policy and Practice, UCL Institute of Child Health, London WC1N 1EH, UK., Province MA; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri 63018, USA., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Schlessinger D; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Schmidt R; Department of Neurology, General Hospital and Medical University Graz, Graz 8036, Austria., Sørensen TI; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen 2100, Denmark.; 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Publikováno v:
Nature [Nature] 2016 May 26; Vol. 533 (7604), pp. 539-42. Date of Electronic Publication: 2016 May 11.
Autor:
Zheng HF; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada., Forgetta V; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada., Hsu YH; Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.; Broad Institute of MIT and Harvard, Boston, Massachusetts 02115, USA., Estrada K; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.; Broad Institute of MIT and Harvard, Boston, Massachusetts 02115, USA.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA., Rosello-Diez A; Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA., Leo PJ; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia., Dahia CL; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065, USA.; Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York 10021, USA., Park-Min KH; Rheumatology Divison, Hospital for Special Surgery New York, New York 10021, USA., Tobias JH; School of Clinical Science, University of Bristol, Bristol BS10 5NB, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Kooperberg C; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kleinman A; Department of Research, 23andMe, Mountain View, California 94041, USA., Styrkarsdottir U; Department of Population Genomics, deCODE Genetics, Reykjavik IS-101, Iceland., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Uggla C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden., Evans DS; California Pacific Medical Center Research Institute, San Francisco, California 94158, USA., Nielson CM; Department of Public Health and Preventive Medicine, Oregon Health &Science University, Portland, Oregon 97239, USA.; Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA., Walter K; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Pettersson-Kymmer U; Departments of Pharmacology and Clinical Neurosciences, Umeå University, Umeå S-901 87, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden., McCarthy S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Eriksson J; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden.; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden., Kwan T; McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada., Jhamai M; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands., Trajanoska K; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands., Memari Y; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Min J; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Huang J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Danecek P; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Wilmot B; Oregon Clinical and Translational Research Institute, Oregon Health &Science University, Portland, Oregon 97239, USA.; Department of Medical and Clinical Informatics, Oregon Health &Science University, Portland, Oregon 97239, USA., Li R; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada., Chou WC; Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA., Mokry LE; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada., Moayyeri A; Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Claussnitzer M; Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.; Broad Institute of MIT and Harvard, Boston, Massachusetts 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA., Cheng CH; Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA., Cheung W; McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1B1, Canada., Medina-Gómez C; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands., Ge B; McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada., Chen SH; McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada., Choi K; Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA., Oei L; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands., Fraser J; Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal H3G 1Y6, Canada., Kraaij R; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands., Hibbs MA; Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA.; Department of Computer Science, Trinity University, San Antonio, Texas 78212, USA., Gregson CL; Musculoskeletal Research Unit, University of Bristol, Bristol BS10 5NB, UK., Paquette D; Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal H3G 1Y6, Canada., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands., Wibom C; Department of Radiation Sciences, Umeå University, Umeå S-901 87, Sweden., Tranah GJ; Department of Public Health and Preventive Medicine, Oregon Health &Science University, Portland, Oregon 97239, USA.; Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA., Marshall M; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia., Gardiner BB; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia., Cremin K; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia., Auer P; School of Public Health, University of Wisconsin, Milwaukee, Wisconsin 53726, USA., Hsu L; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Ring S; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Tung JY; Department of Research, 23andMe, Mountain View, California 94041, USA., Thorleifsson G; Department of Statistics, deCODE Genetics, Reykjavik IS-101, Iceland., Enneman AW; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands., van Schoor NM; Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam 1007 MB, The Netherlands., de Groot LC; Department of Human Nutrition, Wageningen University, Wageningen 6700 EV, The Netherlands., van der Velde N; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Internal Medicine, Section Geriatrics, Academic Medical Center, Amsterdam 1105, The Netherlands., Melin B; Department of Radiation Sciences, Umeå University, Umeå S-901 87, Sweden., Kemp JP; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Christiansen C; Nordic Bioscience, Herlev 2730, Denmark., Sayers A; Musculoskeletal Research Unit, University of Bristol, Bristol BS10 5NB, UK., Zhou Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Calderari S; Cordeliers Research Centre, INSERM UMRS 1138, Paris 75006, France.; Institute of Cardiometabolism and Nutrition, University Pierre &Marie Curie, Paris 75013, France., van Rooij J; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands., Carlson C; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Peters U; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Berlivet S; Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal H3G 1Y6, Canada., Dostie J; Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal H3G 1Y6, Canada., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands., Williams SR; Departments of Medicine (Cardiovascular Medicine), Centre for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA., Farber C; Departments of Medicine (Cardiovascular Medicine), Centre for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA., Grinberg D; Department of Genetics, University of Barcelona, Barcelona 08028, Spain.; U-720, Centre for Biomedical Network Research on Rare Diseases (CIBERER), Barcelona 28029, Spain.; Department of Human Molecular Genetics, The Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona 08028, Spain., LaCroix AZ; Women's Health Center of Excellence Family Medicine and Public Health, University of California - San Diego, San Diego, California 92093, USA., Haessler J; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Chasman DI; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Ridker PM; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Eisman JA; Osteoporosis &Bone Biology Program, Garvan Institute of Medical Research, Sydney 2010, Australia.; School of Medicine Sydney, University of Notre Dame Australia, Sydney 6959, Australia.; St. Vincent's Hospital &Clinical School, NSW University, Sydney 2010, Australia., Nguyen TV; Osteoporosis &Bone Biology Program, Garvan Institute of Medical Research, Sydney 2010, Australia.; St. Vincent's Hospital &Clinical School, NSW University, Sydney 2010, Australia., Center JR; Osteoporosis &Bone Biology Program, Garvan Institute of Medical Research, Sydney 2010, Australia.; St. Vincent's Hospital &Clinical School, NSW University, Sydney 2010, Australia., Nogues X; Musculoskeletal Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona 08003, Spain.; Cooperative Research Network on Aging and Fragility (RETICEF), Institute of Health Carlos III, 28029, Spain.; Department of Internal Medicine, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona 08193, Spain., Garcia-Giralt N; Musculoskeletal Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona 08003, Spain.; Cooperative Research Network on Aging and Fragility (RETICEF), Institute of Health Carlos III, 28029, Spain., Launer LL; Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Gudnason V; Icelandic Heart Association, Kopavogur IS-201, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden., Vandenput L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden., Amin N; Genetic epidemiology unit, Department of Epidemiology, Erasmus MC, Rotterdam 3000CA, The Netherlands., van Duijn CM; Genetic epidemiology unit, Department of Epidemiology, Erasmus MC, Rotterdam 3000CA, The Netherlands., Karlsson MK; Department of Orthopaedics, Skåne University Hospital Malmö 205 02, Sweden., Ljunggren Ö; Department of Medical Sciences, University of Uppsala, Uppsala 751 85, Sweden., Svensson O; Department of Surgical and Perioperative Sciences, Umeå Unviersity, Umeå 901 85, Sweden., Hallmans G; Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden., Rousseau F; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City G1V 0A6, Canada.; Axe Santé des Populations et Pratiques Optimales en Santé, Centre de recherche du CHU de Québec, Québec City G1V 4G2, Canada., Giroux S; Axe Santé des Populations et Pratiques Optimales en Santé, Centre de recherche du CHU de Québec, Québec City G1V 4G2, Canada., Bussière J; Axe Santé des Populations et Pratiques Optimales en Santé, Centre de recherche du CHU de Québec, Québec City G1V 4G2, Canada., Arp PP; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands., Koromani F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands., Prince RL; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands 6009, Australia.; Department of Medicine, University of Western Australia, Perth 6009, Australia., Lewis JR; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands 6009, Australia.; Department of Medicine, University of Western Australia, Perth 6009, Australia., Langdahl BL; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C 8000, Denmark., Hermann AP; Department of Endocrinology, Odense University Hospital, Odense C 5000, Denmark., Jensen JE; Department of Endocrinology, Hvidovre University Hospital, Hvidovre 2650, Denmark., Kaptoge S; Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK., Khaw KT; Clinical Gerontology Unit, University of Cambridge, Cambridge CB2 2QQ, UK., Reeve J; Medicine and Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Institute of Musculoskeletal Sciences, The Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK., Formosa MM; Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida MSD 2080, Malta., Xuereb-Anastasi A; Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida MSD 2080, Malta., Åkesson K; Department of Orthopaedics, Skåne University Hospital Malmö 205 02, Sweden.; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, 205 02, Sweden., McGuigan FE; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, 205 02, Sweden., Garg G; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, 205 02, Sweden., Olmos JM; Department of Medicine and Psychiatry, University of Cantabria, Santander 39011, Spain.; Department of Internal Medicine, Hospital U.M. Valdecilla- IDIVAL, Santander 39008, Spain., Zarrabeitia MT; Department of Legal Medicine, University of Cantabria, Santander 39011, Spain., Riancho JA; Department of Medicine and Psychiatry, University of Cantabria, Santander 39011, Spain.; Department of Internal Medicine, Hospital U.M. Valdecilla- IDIVAL, Santander 39008, Spain., Ralston SH; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK., Alonso N; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK., Jiang X; Department of Reconstructive Sciences, College of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA., Goltzman D; Department of Medicine and Physiology, McGill University, Montréal H4A 3J1, Canada., Pastinen T; McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1B1, Canada., Grundberg E; McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1B1, Canada., Gauguier D; Cordeliers Research Centre, INSERM UMRS 1138, Paris 75006, France.; Institute of Cardiometabolism and Nutrition, University Pierre &Marie Curie, Paris 75013, France., Orwoll ES; Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.; Department of Medicine, Oregon Health &Science University, Portland, Oregon 97239, USA., Karasik D; Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed 13010, Israel., Davey-Smith G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Smith AV; Icelandic Heart Association, Kopavogur IS-201, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland., Siggeirsdottir K; Icelandic Heart Association, Kopavogur IS-201, Iceland., Harris TB; Laboratory of Epidemiology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Zillikens MC; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands., van Meurs JB; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands., Thorsteinsdottir U; Department of Population Genomics, deCODE Genetics, Reykjavik IS-101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland., Maurano MT; Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Durbin R; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK., Wilson SG; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands 6009, Australia.; School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia., Ntzani EE; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece.; Department of Health Services, Policy and Practice, Brown University School of Public Health, Providence, Rhode Island 02903, USA., Brown MA; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia., Stefansson K; Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland.; deCODE Genetics, Reykjavik IS-101, Iceland., Hinds DA; Department of Research, 23andMe, Mountain View, California 94041, USA., Spector T; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.; Framingham Heart Study, Framingham, Massachusetts 01702, USA., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden., Greenwood CM; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1B1, Canada.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal H3A 1A2, Canada.; Department of Oncology, Gerald Bronfman Centre, McGill University, Montréal H2W 1S6, Canada., Jackson RD; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA., Rowe DW; Department of Reconstructive Sciences, College of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA., Loomis CA; The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA., Evans DM; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Ackert-Bicknell CL; Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA., Joyner AL; Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA., Duncan EL; The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.; Department of Diabetes and Endocrinology, Royal Brisbane and Women's Hospital, Brisbane 4029, Australia., Kiel DP; Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.; Broad Institute of MIT and Harvard, Boston, Massachusetts 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA., Rivadeneira F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands., Richards JB; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Publikováno v:
Nature [Nature] 2015 Oct 01; Vol. 526 (7571), pp. 112-7. Date of Electronic Publication: 2015 Sep 14.
Autor:
Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Esko T; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Mattsson H; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland., Eklund N; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland., Gandin I; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy., Nutile T; Institute of Genetics and Biophysics 'A. Buzzati-Traverso' CNR, via Pietro Castellino, 111, Naples, 80131, Italy., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Smith AV; Icelandic Heart Association, Holtasmari 1, 201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Okada Y; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo, 113-8510, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Stančáková A; Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Faul JD; Institute for Social Research, University of Michigan, 426 Thompson Street, 48104, Ann Arbor, MI, USA., Zhao W; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Bartz TM; Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA., Concas MP; Institute of Population Genetics, National Research Council, Trav. La Crucca n. 3 - Reg. Baldinca, Sassari, 07100, Italy., Franceschini N; Epidemiology, University of North Carolina, 137 E. Franklin St., Suite 306, 27599-8050, Chapel Hill, USA., Enroth S; Immunology, Genetics & Pathology, Uppsala University, Husargatan 3, Box 815, Uppsala, SE-751 08, Sweden., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Trompet S; Department of Gerontology and Geriatrics, Leiden University Medical Center , PO Box 9600, Leiden, Netherlands., Guo X; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, East, Harvard Medical School, Boston, Boston, MA 02215, USA., O'Connel JR; Division of Endocrinology, Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA., Corre T; Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, Lausanne, 1005, Switzerland.; Swiss Institute of Bioinformatics, Quartier Sorge - batiment génopode, Lausanne, 1015, Switzerland., Nongmaithem SS; Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda, Uppal Road, Hyderabad, 500007, India., Chen Y; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, 02118, MA, USA., Mangino M; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK.; NIHR Biomedical Research Centre , Guy's and St. Thomas' Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK., Ruggiero D; Institute of Genetics and Biophysics 'A. Buzzati-Traverso' CNR, via Pietro Castellino, 111, Naples, 80131, Italy., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Farmaki AE; Department of Nutrition and Dietetics, Harokopio University of Athens, 70, El. Venizelou Ave, Athens, 17671, Greece., Kacprowski T; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15A, Greifswald, 17475, Germany., Bjonnes A; Center for Human Genetic Research , 55 Fruit Street, Massachusetts General Hospital, 2114, USA., van der Spek A; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, 27599, NC, USA., Giri AK; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, Mathura Road, New Delhi, 110025, India., Yanek LR; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA., Wang L; Department of Genetics, Washington University School of Medicine, 4444 Forest Park Boulevard, Saint Louis, 63108, MO, USA., Hofer E; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, Graz, A-8036, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Auenbruggerplatz2, Graz, A-8036, Austria., Rietveld CA; Erasmus School of Economics, Erasmus University Rotterdam, Burgemeester Oudlaan 50, Rotterdam, 3000 DR, The Netherlands., McLeod O; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden., Cornelis MC; Channing Division of Network Medicine, Brigham & Women's Hospital, 181 Longwood, Boston, 02115, USA.; Nutrition, Harvard School of Public Health, 401 Park Drive, Boston, 02215, USA., Pattaro C; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Verweij N; University of Groningen, University Medical Center Groningen, Department of Cardiology, Hanzeplein 1, Groningen, 9700RB, The Netherlands., Baumbach C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., Abdellaoui A; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Vuckovic D; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy., Mei H; Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, 39216, MS, USA., Bouchard C; Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Cappellani S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Mirza SS; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Benton MC; Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, GPO Box 2434, Brisbane Qld 4001, Brisbane, Australia., Broeckel U; Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, 53226, WI, USA., Medland SE; Quantitative Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Lind PA; Quantitative Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Malerba G; Dipartimento di Scienze della Vita e della Riproduzione, University of Verona, Strada Le Grazie 15, Verona, 37134, Italy., Drong A; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Yengo L; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University, 1 Rue du Professeur Calmette, 59000, Lille, France., Bielak LF; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Zhi D; Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, 35294, AL, USA., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, P.O. box 30.001, 9700 RB, Groningen, The Netherlands., Shriner D; Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A/Room 4047, 12 South Dr., Bethesda, 20892, Maryland, USA., Mägi R; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Karaderi T; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, 20850, MD, USA.; Cancer Genomics Research Laboratory, National Cancer Institute, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick,MD, USA., Liu T; Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany.; Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 72, Berlin, 14195, Germany., Demuth I; Charité Research Group on Geriatrics, Charité - Universitätsmedizin Berlin, Reinickendorferstr. 61, 13347, Berlin, Germany.; Institute of Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Meng W; Division of Population Health Sciences, Medical Research Institute, University of Dundee, Ninewells hospital and School of Medicine, Dundee, DD2 4BF, Scotland., Lataniotis L; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., van der Laan SW; Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Bradfield JP; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK., Bonnefond A; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University, 1 Rue du Professeur Calmette, 59000, Lille, France., Ahluwalia TS; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark.; Novo Nordisk Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, Copenhagen, 2100, Denmark., Hall LM; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK., Salvi E; Department of Health Sciences, University of Milan, via A. di Rudinì 8, 20142 Milan, Italy., Yazar S; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, 2 Verdun St, Perth, 6009, Australia., Carstensen L; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark., de Haan HG; Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, Leiden, 2300RC, The Netherlands., Abney M; Department of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL, USA., Afzal U; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Allison MA; Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, 92093, USA., Amin N; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Catharijnesingel 52, Utrecht, 3501 DG, The Netherlands.; Institute of Cardiovascular Science, faculty of Population Health Sciences, University College London, Gower Street, London, WC1E 6BT, UK., Bakker SJL; University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Hanzeplein 1, Groningen, 9700RB, The Netherlands., Barr RG; Department of Medicine, Columbia University, 622 W. 168th Street, New York, 10032, NY, USA., Baumeister SE; Institute for Community Medicine, University Medicine Greifswald, W.-Rathenau-Str. 48, Greifswald, 17475, Germany., Benjamin DJ; Department of Economics, Cornell University, 480 Uris Hall, Ithaca, NY, 14853, USA.; Department of Economics and Center for Economic and Social Research, University of Southern California, 314C Dauterive Hall, 635 Downey Way, Los Angeles, CA, 90089, USA., Bergmann S; Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, Lausanne, 1005, Switzerland.; Swiss Institute of Bioinformatics, Quartier Sorge - batiment génopode, Lausanne, 1015, Switzerland., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, Texas, 77030, USA., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Campbell A; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Chakravarti A; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA., Chan Y; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, 20850, MD, USA., Chen C; Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, 665 Huntington Ave, Boston, 02115, USA., Chen YI; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Collins FS; Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, 20892, MD, USA., Connell J; College of Medicine, Dentistry and Nursing, Ninewells Hospital and Medical School, College Office, Level 10, Dundee, DD1 9SY, UK., Correa A; Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, 39216, MS, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, 02118, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Davies G; Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. NK, Greifswald, 17475, Germany., Ehret G; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, MD, USA.; Cardiology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, 4, Genève 14, 1211, Switzerland., Ellis SB; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark., Feitosa MF; Department of Genetics, Washington University School of Medicine, 4444 Forest Park Boulevard, Saint Louis, 63108, MO, USA., Ford I; Robertson Centre, University of Glasgow, Boyd Orr Building, Glasgow, G12 8QQ, Scotland., Fox CS; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School , 75 Francis St, Boston, 02115, MA, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. NK, 17475, Greifswald, Germany., Geller F; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark., Scotland G; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Gillham-Nasenya I; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Graff M; Epidemiology, University of North Carolina, 137 E Franklin St., Suite 306, USA., Grodstein F; Nutrition, Harvard School of Public Health, 401 Park Drive, Boston, 02215, USA., Gu C; Division of Biostatistics, Washington University, 660 S Euclid, St Louis, 63110, MO, USA., Haley C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Scotland., Hammond CJ; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Harris SE; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Harris TB; National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA., Hastie ND; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Heard-Costa NL; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Department of Neurology, Boston University School of Medicine, 72 E Concord St, Boston, 02118, MA, USA., Heikkilä K; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland., Hocking LJ; Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15A, Greifswald, 17475, Germany., Hottenga JJ; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Huang J; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025 China., Huffman JE; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Hysi PG; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Ikram MA; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.; Department of Radiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Ingelsson E; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Joensuu A; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland., Johansson Å; Immunology, Genetics & Pathology, Uppsala University, Husargatan 3, Box 815, Uppsala, SE-751 08, Sweden.; Uppsala Clinical Research Center, Uppsala University, Uppsala, SE-75237, Sweden., Jousilahti P; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Jukema JW; Department of Cardiology C5-P , Leiden University Medical Center, PO Box 9600, Leiden, Netherlands., Kähönen M; Department of Clinical Physiology, University of Tampere and Tampere University Hospital, P.O. Box 2000, Tampere, 33521, Finland., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Kerr SM; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Khan NM; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, Mathura Road, New Delhi, 110025, India., Koellinger P; Erasmus School of Economics, Erasmus University Rotterdam, Burgemeester Oudlaan 50, Rotterdam, 3000 DR, The Netherlands., Koistinen HA; Diabetes Prevention Unit, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, P.O.Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kooner MK; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Kubo M; Laboratory for Genotyping Development RCfIMS, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., Lahti J; Institute of Behavioural Sciences, University of Helsinki, P.O. Box 9, FI-00014 University of Helsinki, Helsinki, Finland.; Folkhälsan Reasearch Centre, PB 63, Helsinki, FI-00014 University of Helsinki, Finland., Launer LJ; National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA., Lea RA; Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, GPO Box 2434, Brisbane Qld 4001, Brisbane, Australia., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, Tampere, 33520, Finland., Liewald DCM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Lind L; Department of Medical Sciences, University Hospital, Uppsala, 75185, Sweden., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK., Lokki ML; Transplantation laboratory, Haartman Institute, University of Helsinki, P.O. Box 21, Helsinki, FI-00014, Finland., London SJ; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, RTP, NC, USA., Loomis SJ; Ophthalmology, Massachusetts Eye and Ear, 243 Charles St, Boston, 02114, USA., Loukola A; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Lumley T; Department of Statistics, University of Auckland, 303.325 Science Centre, Private Bag 92019, Auckland, 1142, New Zealand., Lundqvist A; Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Männistö S; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Marques-Vidal P; Department of Internal Medicine, University Hospital, Route du Bugnon 44, Lausanne, 1011, Switzerland., Masciullo C; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Matchan A; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Mathias RA; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.; Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21224, USA., Matsuda K; Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan., Meigs JB; Division of General Internal Medicine, Massachusetts General Hospital , 50 Staniford St, Boston, 02114, MA, USA., Meisinger C; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764 Germany.; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, München, 81675, Germany., Menni C; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Mentch FD; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Mihailov E; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Milani L; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA., Montgomery GW; Molecular Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Morrison A; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, Texas, 77030, USA., Myers RH; Genome Science Institute, Boston University School of Medicine, 72 East Concord Street, E-304, Boston, 2118, MA, USA., Nadukuru R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Navarro P; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Nelis M; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia., Nieminen MS; HUCH Heart and Lung center, Helsinki University Central Hospital, P.O. Box 340, Helsinki, FI-00029, Finland., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, P.O. box 30.001, 9700 RB, Groningen, The Netherlands., O'Connor GT; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Pulmonary Center and Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, 02118, MA, USA., Ogunniyi A; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Padmanabhan S; ICAMS, University of Glasgow, 126 University Way, Glasgow, G12 8TA, UK., Palmas WR; Department of Medicine, Columbia University, 622 W. 168th Street, New York, 10032, NY, USA., Pankow JS; Division of Epidemiology and Community Health , University of Minnesota , 1300 S 2nd Street, Minneapolis, 55454, USA., Patarcic I; Centre for Global Health and Department of Public Health, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia., Pavani F; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Peyser PA; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Pietilainen K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland.; Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, P.O.Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, P.O.Box 63, Haartmaninkatu 8, FI-00014, Helsinki, Finland., Poulter N; International Centre for Circulatory Health, Imperial College London, London, W2 1LA, UK., Prokopenko I; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, SW7 2AZ, UK., Ralhan S; Department of Cardiology and Cardio thoracic Surgery Hero DMC Heart Institute, Civil Lines, 141001, Ludhiana, India., Redmond P; Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Rich SS; Department Public Health Sciences, University of Virginia School of Medicine, 3232 West Complex, Charlottesville, 22908, USA., Rissanen H; Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, East, Harvard Medical School, Boston, Boston, MA 02215, USA., Rose R; Department of Psychological & Brain Sciences, Indiana University Bloomington, 1101 E. 10th St., Bloomington, IN 47405, USA., Sala C; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Salako B; Department of Medicine, University of Ibadan, Ibadan, Nigeria., Salomaa V; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Sarin AP; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland., Saxena R; Center for Human Genetic Research , 55 Fruit Street, Massachusetts General Hospital, 2114, USA., Schmidt H; Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, Graz, A-8010, Austria., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK., Sennblad B; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden.; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden., Seshadri S; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA.; Department of Neurology, Boston University School of Medicine, 72 E Concord St, Boston, 02118, MA, USA., Sever P; International Centre for Circulatory Health, Imperial College London, London, W2 1LA, UK., Shrestha S; Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda, Uppal Road, Hyderabad, 500007, India., Smith BH; University of Dundee, Kirsty Semple Way, Dundee, DD2 4DB, UK., Smith JA; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Soranzo N; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA., Southam L; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Stanton AV; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland., Stathopoulou MG; UMR INSERM U1122; IGE-PCV 'Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire', INSERM, University of Lorraine, 30 Rue Lionnois, Nancy, 54000, France., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany., Strawbridge RJ; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden., Suderman MJ; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Tandon N; Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar East, New Delhi, 110029, India., Tang ST; National Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK., Taylor KD; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, USA., Töglhofer AM; Institute of Molecular Biology and Biochemistry, Medical University Graz, Harrachgasse 21, Graz, A-8010, Austria., Tomaszewski M; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK., Tšernikova N; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu, 51010 Estonia., Tuomilehto J; Diabetes Prevention Unit, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria.; Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Vaidya D; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 21205, USA., van Hylckama Vlieg A; Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, Leiden, 2300RC, The Netherlands., van Setten J; Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Vasankari T; Finnish Lung Health Association, Sibeliuksenkatu 11 A 1, Helsinki, FI-00250, Finland., Vedantam S; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Vlachopoulou E; Transplantation laboratory, Haartman Institute, University of Helsinki, P.O. Box 21, Helsinki, FI-00014, Finland., Vozzi D; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Vuoksimaa E; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., Ware EB; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Wentworth-Shields W; Department of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL, USA., Whitfield JB; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Wild S; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Willemsen G; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Yajnik CS; Diabetes Unit, KEM Hospital and Research Centre, Rasta Peth, Pune, 411011, India., Yao J; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA., Zaza G; Renal Unit, Department of Medicine, Piazzale A. Stefani 1, Verona, 37124, Italy., Zhu X; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, USA., Project TBJ; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Salem RM; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Melbye M; Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen, 2300, Denmark.; Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, 94305, CA, USA., Bisgaard H; Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK., Cusi D; Department of Health Sciences, University of Milan, via A. di Rudinì 8, 20142 Milan, Italy., Mackey DA; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, 2 Verdun St, Perth, 6009, Australia., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, USA., Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University, 1 Rue du Professeur Calmette, 59000, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, SW7 2AZ, UK., Pasterkamp G; Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Grant SFA; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA., Ferrucci L; Translational Gerontology Branch, National institute on Aging, Baltimore, 21225, Maryland, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Morris AD; Jacqui Wood Cancer Centre, Medical Research Insitute, University of Dundee, Ninewells hospital and School of Medicine, Dundee, DD1 9SY, Scotland., Palmer CNA; Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, University of Dundee, Ninewells hospital and School of Medicine, Dundee, DD1 9SY, Scotland., Dedoussis G; Department of Nutrition and Dietetics, Harokopio University of Athens, 70, El. Venizelou Ave, Athens, 17671, Greece., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Bertram L; Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 72, Berlin, 14195, Germany.; Faculty of Medicine, Imperial College London, Charing Cross Campus - St Dunstan's Road, London, W6 8RP, UK., Lindenberger U; Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, Berlin, 14195, Germany., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, 20850, MD, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Sørensen TIA; Novo Nordisk Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, Copenhagen, 2100, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital , The Capital Region, Copenhagen, 2000, Denmark., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A/Room 4047, 12 South Dr., Bethesda, 20892, Maryland, USA., Arnett DK; Department of Epidemiology, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, 35294, AL, USA., Oldehinkel AJ; Department of Psychiatry, University Medical Center Groningen, University of Groningen, P.O. box 30.001, Groningen, 9700 RB, The Netherlands., Kardia SLR; Department of Epidemiology, University of Michigan, 1415 Washington Heights, 48109, Ann Arbor, MI, USA., Balkau B; Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, Inserm, CESP Center for Research in Epidemiology and Population Health U1018, 16 Avenue Paul Vaillant Couturier, Villejuif, 94807, France., Gambaro G; Dipartimento di Scienze Mediche, Catholic University of the Sacred Heart, Via G. Moscati 31/34, Roma, 00168, Italy., Morris AP; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Duncan Building, Daulby Stree, Liverpool, L69 3GA, UK., Eriksson JG; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, P.O. Box 20, University of Helsinki, Helsinki, FI-00014, Finland.; Vasa Central Hospital, Sandviksgatan 2-4, Vasa, 65130, Finland.; Folkhälsan Reasearch Centre, PB 63, University of Helsinki, Helsinki, FI-00014, Finland.; Unit of General Practice, Helsinki University Central Hospital, Haartmaninkatu 4, Helsinki, FI-00290, Finland., Wright MJ; Neuro-Imaging Genetics, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006 Australia., Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, Brisbane, 4006, Australia., Hunt SC; Cardiovascular Genetics Division, University of Utah, 420 Chipeta Way, Room 1160, Salt Lake City, 84117, Utah, USA., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Deary IJ; Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Griffiths LR; Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, GPO Box 2434, Brisbane Qld 4001, Brisbane, Australia., Tiemeier H; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.; Department of Psychiatry, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Pirastu N; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy.; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, P.O. Box 20, Helsinki, FI-00014, Finland.; Department of Public Health, University of Helsinki, Hjelt Institute, P.O.Box 41, Mannerheimintie 172, Helsinki, FI-00014, Finland.; National Institute for Health and Welfare (THL), P.O.Box 30, Mannerheimintie 166, Helsinki, FI-00271, Finland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Pérusse L; Department of kinesiology, Laval University, 2300 rue de la Terrasse, Quebec, G1V 0A6, Canada., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N. State St., Jackson, 39216, MS, USA., Girotto G; Department of Medical Sciences, University of Trieste, Strada di Fiume 447 - Osp. di Cattinara, Trieste, 34149, Italy., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Raitakari O; Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, 20521, Finland.; Research Center of Applied and Preventive Cardiovascular medicine, University of Turku, Turku, 20521, Finland., Boomsma DI; Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, Neuherberg, 85764, Germany., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Hanzeplein 1, Groningen, 9700RB, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Catharijnesingel 52, Utrecht, 3501 DG, The Netherlands.; University of Groningen, University Medical Center Groningen, Department of Genetics, Hanzeplein 1, Groningen, 9700RB, The Netherlands., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, 665 Huntington Ave, Boston, 02115, USA., Sinisalo J; HUCH Heart and Lung center, Helsinki University Central Hospital, P.O. Box 340, Helsinki, FI-00029, Finland., Knekt P; Department of Health, Functional Capacity and Welfare, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Johannesson M; Department of Economics, Stockholm School of Economics, Box 6501, Stockholm, SE-113 83, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, SE-171 77, Sweden., Hamsten A; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, CMM L8:03, Karolinska University Hospital, Solna, Stockholm, 171 76, Sweden., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Auenbruggerplatz 22, Graz, A-8036, Austria., Borecki IB; Department of Genetics and Biostatistics, Washington University School of Medicine, 4444 Forest Park Boulevard, Saint Louis, 63108, MO, USA., Vartiainen E; Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Becker DM; The GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21287, Maryland, USA.; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, 21205, Maryland, USA., Bharadwaj D; Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, Mathura Road, New Delhi, 110025, India., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, 27599, NC, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, MI, USA., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands., Sanghera DK; Department of Pediatrics, University of Oklahoma Health Sciences Center, 940 Stanton Young Boulevard, Oklahoma City, 73104, OK , USA.; Department of Pharmaceutical Sciences , University of Oklahoma Health Sceienecs Center, Oklahoma City , 73104, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, W.-Rathenau-Str. 48, Greifswald, 17475, Germany., Zeggini E; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK., Metspalu A; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu, 51010 Estonia., Gasparini P; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', via dell'Istria 65, Trieste, 34137, Italy., Ober C; Department of Human Genetics, University of Chicago, 920 E. 58th Street, Chicago, IL, USA., Toniolo D; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano, 20132, Italy., Rudan I; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Porteous DJ; Centre for Genomic and Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Ciullo M; Institute of Genetics and Biophysics 'A. Buzzati-Traverso' CNR, via Pietro Castellino, 111, Naples, 80131, Italy., Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, South Wing, Block D, 3rd Floor, Westminster Bridge Road, London, SE1 7EH, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Dupuis J; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, 02118, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt. Wayte Ave, Framingham, 01702, MA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, 10029, USA., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK., Chandak GR; Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda, Uppal Road, Hyderabad, 500007, India.; Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore, 138672, Singapore., Vollenweider P; Department of Internal Medicine, University Hospital, Route du Bugnon 44, Lausanne, 1011, Switzerland., Shuldiner A; Division of Endocrinology, Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA.; Program for Personalised and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, 685 Baltimore St. MSTF, Baltimore, 21201, USA.; Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, 685 W Baltimore MSTF, Baltimore, 21201, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, East, Harvard Medical School, Boston, Boston, MA 02215, USA., Rotter JI; Institute for Translational Genomics and Population Sciences , Los Angeles Biomedical Research Institute, 1124 W. Carson Street, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Sattar N; BHF centre, University of Glasgow, 126 University Avenue, Glasgow, G12 8TA, Scotland., Gyllensten U; Immunology, Genetics & Pathology, Uppsala University, Husargatan 3, Box 815, Uppsala, SE-751 08, Sweden., North KE; Epidemiology, University of North Carolina, 137 E Franklin St., Suite 306, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, 137 E. Franklin St., Suite 306, Chapel Hill, USA., Pirastu M; Institute of Population Genetics, National Research Council, Trav. La Crucca n. 3 - Reg. Baldinca, Sassari, 07100, Italy., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA.; Group Health Research Institute, Group Health Cooperative, 1730 Minor Ave, Suite 1360, Seattle, 98101, WA, USA., Weir DR; Institute for Social Research, University of Michigan, 426 Thompson Street, 48104, Ann Arbor, MI, USA., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland., Gudnason V; Icelandic Heart Association, Holtasmari 1, 201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK.; Imperial College Healthcare NHS Trust, Imperial College London, Praed Street, London, W2 1NY, UK., Kooner JS; Department of Cardiology, Ealing Hospital NHS Trust, Uxbridge Road, Southall, Middlesex, UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, Imperial College London, Praed Street, London, W2 1NY, UK., Strachan DP; Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK., Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Hirschhorn JN; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, 02141, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge Center 7, Cambridge, 02242, MA, USA.; Department of Genetics, Harvard Medical School, 25 Shattuck St, Boston, 02115, MA, USA., Perola M; Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.; Unit of Public Health Genomics, National Institute for Health and Welfare, P.O. Box 104, Helsinki, FI-00251, Finland., Polašek O; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; Centre for Global Health and Department of Public Health, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia., Wilson JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, EH4 2XU, Edinburgh, UK.
Publikováno v:
Nature [Nature] 2015 Jul 23; Vol. 523 (7561), pp. 459-462. Date of Electronic Publication: 2015 Jul 01.
Autor:
Shungin D; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Odontology, Umeå University, Umeå 901 85, Sweden., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany., Croteau-Chonka DC; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Locke AE; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA., Mägi R; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Strawbridge RJ; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark., Fischer K; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Workalemahu T; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Wu JMW; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Buchkovich ML; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Heard-Costa NL; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA., Roman TS; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Song C; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Gustafsson S; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Esko T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Fall T; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Kutalik Z; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Randall JC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Scherag A; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.; Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany., Vedantam S; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Chen J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA., Fehrmann R; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Karjalainen J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Kahali B; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Schmidt EM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands., Anderson D; Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia., Beekman M; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bragg-Gresham JL; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.; Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI 48109., Buyske S; Department of Statistics & Biostatistics, Rutgers University, Piscataway, NJ USA.; Department of Genetics, Rutgers University, Piscataway, NJ USA., Demirkan A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Feitosa MF; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Jackson AU; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA., Johnson T; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland.; University Institute for Social and Preventative Medecine, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne 1005, Switzerland., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Kristiansson K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Leach IM; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Medina-Gomez C; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Palmer CD; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany., Peters MJ; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK., Stančáková A; University of Eastern Finland, FI-70210 Kuopio, Finland., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Yengo L; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Zhang W; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ärnlöv J; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; School of Health and Social Studies, Dalarna University, Falun, Sweden., Arscott GM; PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Barrett A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Bellis C; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Berne C; Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden., Blüher M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Böhringer S; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bonnet F; Inserm UMR991, Department of Endocrinology, University of Rennes, F-35000 Rennes, France., Böttcher Y; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany., Bruinenberg M; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Carba DB; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Caspersen IH; Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway., Clarke R; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Daw EW; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Deelen J; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Deelman E; Information Sciences Institute, University of Southern California, Marina del Rey, California, USA., Delgado G; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany., Doney AS; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Eklund N; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Erdos MR; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Estrada K; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Eury E; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden., Gigante B; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Go AS; Kaiser Permanente, Division of Research, Oakland, CA 94612, USA., Golay A; Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland., Grallert H; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grammer TB; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany., Gräßler J; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Grewal J; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Haller T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Hallmans G; Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Hassinen M; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, Scotland, UK., Heikkilä K; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Herzig KH; Institute of Biomedicine, University of Oulu, Oulu, Finland.; Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland.; Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland., Helmer Q; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands., Hillege HL; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Hunt SC; Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, Leiden, The Netherlands., Ittermann T; Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., James AL; Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.; School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia., Johansson I; Department of Odontology, Umeå University, Umeå 901 85, Sweden., Juliusdottir T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kalafati IP; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Kinnunen L; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Koenig W; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Kooner IK; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Lamina C; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria., Leander K; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Lindström J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lobbens S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Lorentzon M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Mach F; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Merger S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Mills R; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Moayyeri A; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK., Monda KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; The Center for Observational Research, Amgen, Inc., Thousand Oaks, CA 91320, USA., Mooijaart SP; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Mühleisen TW; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Institute of Human Genetics, University of Bonn, Bonn, Germany., Mulas A; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Müller G; Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany., Nagaraja R; Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Glorioso N; Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy., Nolte IM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Olden M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Renstrom F; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Scholtens S; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Sennblad B; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden., Seufferlein T; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Sitlani CM; Department of Medicine, University of Washington, Seattle, WA 98101, USA., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Stirrups K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK., Stringham HM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Swertz MA; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Syvänen AC; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA., Thorand B; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Thorleifsson G; deCODE Genetics, Amgen inc., Reykjavik 101, Iceland., Tomaschitz A; Department of Cardiology, Medical University of Graz, Graz 8036, Austria., Troffa C; Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy., van Oort FV; Department of Child and Adolescent Psychiatry, Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Vonk JM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA., Wennauer R; Department of Clinical Chemistry, Ulm University Medical Centre, D-89081 Ulm, Germany., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Zhang Q; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Brennan EP; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland., Choi M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Eriksson P; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Folkersen L; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden., Gharavi AG; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA., Hedman ÅK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Hivert MF; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA.; Massachusetts General Hospital, Boston, MA, USA., Huang J; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK., Keildson S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kiryluk K; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA., Liang L; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, MA 2115, USA., Lifton RP; Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven CT, USA., Ma B; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China., McKnight AJ; Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, Co. Down BT9 7AB, UK., McPherson R; University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Min JL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Moffatt MF; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Murabito JM; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA.; Section of General Internal Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Nicholson G; Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.; MRC Harwell, Harwell Science and Innovation Campus, Harwell, UK., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia., Olsson C; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden., Perry JR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Reinmaa E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Salem RM; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Sandholm N; Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki, Finland.; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland., Schadt EE; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10580, USA., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Stolk L; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Vallejo EE; Computer Science Department, Tecnológico de Monterrey, Atizapán de Zaragoza, 52926, Mexico., Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK., Amouyel P; Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France., Arveiler D; Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France., Bakker SJ; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Beilby J; PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, CA, USA., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA., Brown MJ; Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK., Burnier M; Service of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne 1005, Switzerland., Campbell H; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Claudi-Boehm S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Crawford DC; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., de Geus EJ; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.; Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Erbel R; Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany., Eriksson JG; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Ferrannini E; Department of Internal Medicine, University of Pisa, Pisa, Italy.; National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy., Ferrières J; Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Forrester T; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., Franco OH; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA., Hattersley AT; Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK., Heliövaara M; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Hicks AA; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany., Hingorani AD; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Hoffmann W; Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Hofman A; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Humphries SE; Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK., Hyppönen E; Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.; School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland.; National Institute for Health and Welfare, FI-90101 Oulu, Finland.; MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.; Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland.; Institute of Health Sciences, FI-90014 University of Oulu, Finland., Johansen B; Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway., Jousilahti P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Jula AM; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kaprio J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kee F; UK Clinical Research Collaboration Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast, Northern Ireland., Keinanen-Kiukaanniemi SM; Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care/General Practice, Oulu University Hospital, Oulu, Finland., Kooner JS; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Kovacs P; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Kraja AT; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Kumari M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.; Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK., Kuulasmaa K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kuusisto J; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland., Lyssenko V; Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Männistö S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Marette A; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada., Matise TC; Department of Genetics, Rutgers University, Piscataway, NJ USA., McKenzie CA; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., McKnight B; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Musk AW; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia., Möhlenkamp S; Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany., Morris AD; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Nelis M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Palmer LJ; Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario, Canada.; Genetic Epidemiology & Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada., Penninx BW; Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands.; Department of Psychiatry, Neuroscience Campus, VU University Amsterdam, Amsterdam, The Netherlands., Peters A; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Pramstaller PP; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy - Affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany.; Department of Neurology, General Central Hospital, Bolzano 39100, Italy., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Rao DC; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Rice TK; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Ritchie MD; Center for Systems Genomics, The Pennsylvania State University, University Park, PA 16802, USA., Rudan I; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN 37203, USA.; Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK., Saramies J; South Carelia Central Hospital, 53130 Lappeenranta, Finland., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Schwarz PE; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany., Shuldiner AR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, MD 21201, USA., Staessen JA; Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.; Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, B-3000 Leuven, Belgium., Steinthorsdottir V; deCODE Genetics, Amgen inc., Reykjavik 101, Iceland., Stolk RP; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Tönjes A; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Tremblay A; Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada., Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, italy., Vohl MC; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Food Science and Nutrition, Laval University, Quebec, QC G1V 0A6, Canada., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Vollenweider P; Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, 1011, Switzerland., Wilson JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK., Witteman JC; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA., Bochud M; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Boehm BO; Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Bornstein SR; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA., Cauchi S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Caulfield MJ; Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Chambers JC; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.; Harvard Medical School, Boston, MA 02115, USA., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 61053, USA., Dedoussis G; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore MD 21225, USA., Froguel P; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany., Hamsten A; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Hui J; PathWest Laboratory Medicine of Western Australia, NEDLANDS, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.; School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia., Hveem K; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany., Kivimaki M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Laakso M; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.; Synlab Academy, Synlab Services GmbH, Mannheim, Germany., Munroe PB; Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, Leiden, The Netherlands.; Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Palmer CN; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Perola M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Pérusse L; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Kinesiology, Laval University, Quebec, QC G1V 0A6, Canada., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Power C; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Quertermous T; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Rivadeneira F; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Saaristo TE; Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Saleheen D; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.; Center for Non-Communicable Diseases, Karatchi, Pakistan.; Department of Medicine, University of Pennsylvania, Philadelphia, USA., Sinisalo J; Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland., Slagboom PE; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Stefansson K; deCODE Genetics, Amgen inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Stumvoll M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Tuomilehto J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain.; Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria., Uitterlinden AG; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.; Research Unit, Kuopio University Hospital, Kuopio, Finland., van der Harst P; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands., Veronesi G; EPIMED Research Center, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Wichmann HE; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.; Klinikum Grosshadern, D-81377 Munich, Germany.; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Abecasis GR; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA., Assimes TL; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Boehnke M; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA., Borecki IB; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Deloukas P; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Franke L; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Groop LC; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Hunter DJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA., Kaplan RC; Albert Einstein College of Medicine. Department of Epidemiology and Population Health, Belfer 1306, NY 10461, USA., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Qi L; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Schlessinger D; Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA., Strachan DP; Division of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK., Thorsteinsdottir U; deCODE Genetics, Amgen inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, Leiden, The Netherlands., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Visscher PM; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Yang J; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Hirschhorn JN; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Zillikens MC; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LJ, UK., Speliotes EK; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Fox CS; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA., Barroso I; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK., Franks PW; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Ingelsson E; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Heid IM; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Loos RJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham MA 01702, USA., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 02142, MA, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Publikováno v:
Nature [Nature] 2015 Feb 12; Vol. 518 (7538), pp. 187-196.
Autor:
Locke AE; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kahali B; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby 2800, Denmark., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Powell C; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Vedantam S; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Buchkovich ML; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Yang J; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Croteau-Chonka DC; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Esko T; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Fall T; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gustafsson S; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Kutalik Z; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Randall JC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Workalemahu T; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA., Chen J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA., Fehrmann R; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Hedman ÅK; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Karjalainen J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schmidt EM; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA., Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Amin N; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands., Anderson D; Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia., Beekman M; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bolton JL; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Bragg-Gresham JL; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, Michigan 48109, USA., Buyske S; Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA.; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., Demirkan A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands., Deng G; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Gastroenterology and Hepatology, Imperial College London, London W2 1PG, UK.; Institute of infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China., Ehret GB; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Feitosa MF; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Fischer K; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Goel A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Gong J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Jackson AU; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Kristiansson K; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lim U; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lotay V; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Leach IM; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Medina-Gomez C; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA., Palmer CD; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA., Pasko D; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Peters MJ; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK., Shungin D; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.; Department of Odontology, Umeå University, Umeå 901 85, Sweden., Stančáková A; University of Eastern Finland, FI-70210 Kuopio, Finland., Strawbridge RJ; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Trompet S; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., van der Laan SW; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Setten J; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Wang Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Yengo L; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Zhang W; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ärnlöv J; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; School of Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden., Arscott GM; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia., Attwood AP; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy., Barrett A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Bas IN; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Bellis C; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4001, Australia., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Berne C; Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden., Blagieva R; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Blüher M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Böhringer S; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Böttcher Y; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Bruinenberg M; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Caspersen IH; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Chen YI; Department of Pediatrics, University of California Los Angeles, Torrance, California 90502, USA.; Transgenomics Institute, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA., Clarke R; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Daw EW; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., de Craen AJM; Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Delgado G; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Doney ASF; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Eklund N; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Estrada K; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA., Eury E; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Folkersen L; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Fraser RM; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden., Gigante B; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Go AS; Kaiser Permanente, Division of Research, Oakland, California 94612, USA., Golay A; Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland., Goodall AH; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Gorski M; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, D-93053 Regensburg, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany., Grallert H; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Grammer TB; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany., Gräßler J; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Grönberg H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Gusto G; Institut inter Régional pour la Santé, Synergies, F-37520 La Riche, France., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Haller T; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Hallmans G; Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Hassinen M; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Heard-Costa NL; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Helmer Q; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Faculty of Psychology and Education, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Hengstenberg C; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Hottenga JJ; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., James AL; Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.; School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia., Jeff JM; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Johansson Å; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Jolley J; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.; NHS Blood and Transplant, Cambridge CB2 0PT, UK., Juliusdottir T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kinnunen L; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Koenig W; Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany., Koskenvuo M; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Laitinen J; Finnish Institute of Occupational Health, FI-90100 Oulu, Finland., Lamina C; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria., Leander K; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Lindström J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Lo KS; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada., Lobbens S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Lorbeer R; Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Lu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Mach F; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., McLachlan S; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Merger S; Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Moayyeri A; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK., Monda KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; The Center for Observational Research, Amgen, Inc., Thousand Oaks, California 91320, USA., Morken MA; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Mulas A; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Müller G; Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Musk AW; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia., Nagaraja R; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Nöthen MM; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany., Nolte IM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Pilz S; Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands.; Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Renstrom F; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden., Rettig R; Institute of Physiology, University Medicine Greifswald, D-17495 Karlsburg, Germany., Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Scholtens S; LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Schumacher FR; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Scott WR; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Seufferlein T; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Shi J; National Cancer Institute, Bethesda, Maryland 20892, USA., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Smolonska J; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Stanton AV; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland., Steinthorsdottir V; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Stirrups K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Stringham HM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden., Swertz MA; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Syvänen AC; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden., Tan ST; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Tayo BO; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., Thorand B; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Thorleifsson G; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland., Tyrer JP; Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK., Uh HW; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vandenput L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Verhulst FC; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands., Vermeulen SH; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Genetics, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Vonk JM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA., Warren HR; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Waterworth D; Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA., Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Willenborg C; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Wojczynski MK; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Zhang Q; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Brennan EP; Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland., Choi M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea., Dastani Z; Lady Davis Institute, Departments of Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal, Québec H3T1E2, Canada., Drong AW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Eriksson P; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden., Gådin JR; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Gharavi AG; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Goddard ME; Biosciences Research Division, Department of Primary Industries, Victoria 3083, Australia.; Department of Food and Agricultural Systems, University of Melbourne, Victoria 3010, Australia., Handsaker RE; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK., Kathiresan S; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Keildson S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Kiryluk K; Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA., Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Lee JY; Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Chungbuk 363-951, Republic of Korea., Liang L; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Harvard School of Public Health, Department of Biostatistics, Harvard University, Boston, Massachusetts 2115, USA., Lifton RP; Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, Connecticut 06520, USA., Ma B; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning 116026, China., McCarroll SA; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA., McKnight AJ; Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, County Down BT9 7AB, UK., Min JL; School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK., Moffatt MF; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., Murabito JM; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Section of General Internal Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Nicholson G; Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.; MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0QG, UK., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia., Okada Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., Perry JRB; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, 138672 Singapore., Reinmaa E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Salem RM; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Sandholm N; Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki FI-00076, Finland.; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Stolk L; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan., Tanaka T; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.; Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.; Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan., van 't Hooft FM; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Vinkhuyzen AAE; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia., Westra HJ; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Zheng W; Division of Epidemiology, Department of Medicine; Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37075, USA., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK., Heath AC; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Arveiler D; Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Beilby J; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia., Bergman RN; Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, California 90048, USA., Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA., Bovet P; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Campbell H; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Caulfield MJ; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Cesana G; University of Milano, Bicocca, 20126, Italy., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Crawford DC; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA., Cupples LA; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA., Cusi D; Department of Health Sciences, University of Milano, I 20142, Italy.; Fondazione Filarete, Milano I 20139, Italy., Danesh J; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden., den Ruijter HM; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Erbel R; Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45147 Essen, Germany., Erdmann J; German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany., Eriksson JG; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland., Farrall M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Ferrannini E; Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy.; National Research Council Institute of Clinical Physiology, University of Pisa, 56124 Pisa, Italy., Ferrières J; Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Forrester T; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., Franco OH; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands., Gejman PV; NorthShore University HealthSystem, Evanston, IL 60201, University of Chicago, Chicago, Illinois, USA., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., Gottesman O; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland.; University of Iceland, Reykjavik 101, Iceland., Gyllensten U; Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden., Hall AS; Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9LU, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA., Hattersley AT; Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK., Hicks AA; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany)., Hindorff LA; Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Hingorani AD; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Hofman A; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany., Hovingh GK; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Humphries SE; Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK., Hunt SC; Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA., Hyppönen E; Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.; School of Population Health, University of South Australia, Adelaide 5000, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia 5000, Australia.; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Illig T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany., Jacobs KB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; National Institute for Health and Welfare, FI-90101 Oulu, Finland.; MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.; Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Johansen B; Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Jousilahti P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands (ICIN), 3501 DG Utrecht, The Netherlands., Jula AM; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kaprio J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland., Kastelein JJP; Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands., Keinanen-Kiukaanniemi SM; Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.; Unit of Primary Health Care/General Practice, Oulu University Hospital, FI-90220 Oulu, Finland., Kiemeney LA; Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands., Knekt P; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Kooner JS; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Kovacs P; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Kraja AT; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Kumari M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.; Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK., Kuusisto J; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Lakka TA; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, FI-70211 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Marchand LL; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland., Lyssenko V; Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Männistö S; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Marette A; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada., Matise TC; Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA., McKenzie CA; UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica., McKnight B; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Moll FL; Department of Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Morris AD; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Morris AP; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA., Nelis M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Madden PAF; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Pasterkamp G; Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Peden JF; Illumina, Inc, Little Chesterford, Cambridge CB10 1XL, UK., Peters A; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Postma DS; University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, Groningen, The Netherlands., Pramstaller PP; Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).; Department of Neurology, General Central Hospital, Bolzano 39100, Italy., Price JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Qi L; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Rao DC; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Rice TK; Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts 02115, USA., Rioux JD; Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.; Université de Montréal, Montreal, Quebec H1T 1C8, Canada., Ritchie MD; Center for Systems Genomics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA., Rudan I; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.; Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia., Salomaa V; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK., Saramies J; South Carelia Central Hospital, 53130 Lappeenranta, Finland., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Schunkert H; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.; Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany., Schwarz PEH; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.; Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), 01307 Dresden, Germany., Sever P; International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK., Shuldiner AR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21201, USA., Sinisalo J; Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland., Stolk RP; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany., Tönjes A; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Trégouët DA; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1166, F-75013 Paris, France.; INSERM, UMR S 1166, Team Genomics and Physiopathology of Cardiovascular Diseases, F-75013 Paris, France.; Institute for Cardiometabolism And Nutrition (ICAN), F-75013 Paris, France., Tremblay A; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy., Virtamo J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Vohl MC; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Food Science and Nutrition, Laval University, Quebec QC G1V 0A6, Canada., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany., Waeber G; Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1011, Switzerland., Willemsen G; Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands., Witteman JC; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Zillikens MC; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Amouyel P; Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France., Asselbergs FW; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Assimes TL; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Bochud M; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.; Ministry of Health, Victoria, Republic of Seychelles., Boehm BO; Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.; Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany., Boerwinkle E; Health Science Center at Houston, University of Texas, Houston, Texas 77030, USA., Bornstein SR; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Cauchi S; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Chambers JC; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Cooper RS; Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA., de Bakker PIW; Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Epidemiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Dedoussis G; Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA., Franks PW; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden., Froguel P; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.; CNRS UMR 8199, F-59019 Lille, France.; European Genomic Institute for Diabetes, F-59000 Lille, France.; Université de Lille 2, F-59000 Lille, France., Groop LC; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA., Hamsten A; Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Hui J; PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia 6009, Australia.; School of Population Health, The University of Western Australia, Nedlands, Western Australia 6009, Australia., Hunter DJ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Hveem K; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway., Kaplan RC; Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Belfer 1306, New York 10461, USA., Kivimaki M; Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK., Laakso M; Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Liu Y; Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.; Synlab Academy, Synlab Services GmbH, 68163 Mannheim, Germany., Melbye M; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.; Department of Clinical Medicine, Copenhagen University, 2200 Copenhagen, Denmark., Metspalu A; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany., Munroe PB; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands.; Department of Clinical Genetics, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands., Palmer CNA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Perola M; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland., Pérusse L; Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.; Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Power C; Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK., Quertermous T; Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA., Rauramaa R; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland., Rivadeneira F; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Saaristo TE; Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.; Pirkanmaa Hospital District, FI-33521 Tampere, Finland., Saleheen D; Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.; Center for Non-Communicable Diseases, Karatchi, Pakistan.; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Schadt EE; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10580, USA., Schlessinger D; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Slagboom PE; Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Thorsteinsdottir U; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Stumvoll M; Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany., Tuomilehto J; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Institute for Health Research, University Hospital of La Paz (IdiPaz), 28046 Madrid, Spain.; Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.; Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria., Uitterlinden AG; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.; Research Unit, Kuopio University Hospital, FI-70210 Kuopio, Finland., van der Harst P; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.; Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands., Walker M; Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK., Wallaschofski H; DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Watkins H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA., Wichmann HE; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.; Klinikum Grosshadern, D-81377 Munich, Germany.; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany., Wilson JF; Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK., Zanen P; Department of Pulmonology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Borecki IB; Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA., Deloukas P; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia., Fox CS; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA., Heid IM; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Strachan DP; Division of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK., Stefansson K; deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.; Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands., Abecasis GR; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Franke L; Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford OX3 7LJ, UK., Visscher PM; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.; The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia., Scherag A; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.; Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07743 Jena, Germany., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Boehnke M; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Lindgren CM; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Beckmann JS; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland.; Service of Medical Genetics, CHUV University Hospital, 1011 Lausanne, Switzerland., Barroso I; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Ingelsson E; Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Hirschhorn JN; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Speliotes EK; Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Publikováno v:
Nature [Nature] 2015 Feb 12; Vol. 518 (7538), pp. 197-206.
Autor:
Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; University of Exeter Medical School, University of Exeter, Exeter, UK EX1 2LU.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Day F; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Elks CE; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Sulem P; deCODE Genetics, Reykjavik, Iceland., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., He C; Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115., Esko T; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Ang WQ; School of Women's and Infants' Health, The University of Western Australia., Corre T; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Cousminer DL; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC., Ganna A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Johnson AD; NHLBI's and Boston University's Framingham Heart Study, Framingham, MA., Kjellqvist S; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden., Lunetta KL; NHLBI's and Boston University's Framingham Heart Study, Framingham, MA.; Boston University School of Public Health, Department of Biostatistics. Boston, MA., McMahon G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Paternoster L; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Porcu E; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; University of Sassari, Dept. Of Biomedical Sciences, Sassari, Italy., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; University of Iceland, Reykjavik, Iceland., Stolk L; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Teumer A; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany., Tšernikova N; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia., Tikkanen E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.; Hjelt Institute, University of Helsinki, Finland., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy., Wagner EK; Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA., Amin N; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Bierut LJ; Dept. of Psychiatry, Washington University, St. Louis, MO 63110., Byrne EM; The University of Queensland, Queensland Brain Institute, St.Lucia, QLD, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Hottenga JJ; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Koller DL; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Pers TH; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA 02115, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US.; Center for Biological Sequence Analysis, Department of Systems Biology, Technical 142 University of Denmark, Lyngby 2800, Denmark., Yerges-Armstrong LM; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Andrulis IL; Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Anton-Culver H; Department of Epidemiology, University of California Irvine, Irvine, California, USA., Atsma F; Sanquin Research, Nijmegen, The Netherlands., Bandinelli S; Tuscany Regional Health Agency, Florence, Italy, I.O.T. and Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy.; Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy., Beckmann MW; University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Benitez J; Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain., Blomqvist C; Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Bojesen SE; Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark., Bolla MK; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Bonanni B; Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy., Brauch H; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart.; University of Tübingen, Germany., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Chanock S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Chen J; Departments of Anatomy and Neurological Surgery, Indiana University school of Medicine, Indianapolis, IN 46202, USA.; Stark Neuroscience Research Center, Indiana University school of Medicine, Indianapolis, IN 46202, USA., Chenevix-Trench G; Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Collée JM; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Couper D; Department of Biostatistics, University of North Carolina, Chapel Hill, NC., Coveillo AD; Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA., Cox A; Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., D'adamo AP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., De Vivo I; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Demerath EW; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minn., USA., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Devilee P; Department of Human Genetics & Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Dieffenbach AK; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Eriksson JG; National Institute for Health and Welfare, Finland.; Department of General Practice and Primary health Care, University of Helsinki, Finland.; Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.; Folkhalsan Research Centre, Helsinki, Finland., Fasching PA; University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Ferrucci L; Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America., Flesch-Janys D; Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany., Flyger H; Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA., Franke L; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Garcia ME; National Insitute on Aging, National Institutes of Health, Baltimore, MD 20892, USA., García-Closas M; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.; Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK., Geller F; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark., de Geus EE; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.; EMGO + Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 Bt, Amsterdam, The Netherlands., Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Gudbjartsson DF; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; University of Iceland, Reykjavik, Iceland., Guénel P; Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.; University Paris-Sud, UMRS 1018, Villejuif, France., Guo S; Department of Obstetrics and Gynecology, Southern Medical University, Guangzhou, China., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Hamann U; Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Haring R; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Heath AC; Washington University, Department of Psychiatry, St.Louis, Missouri, USA., Hofman A; Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands., Hooning MJ; Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Hu FB; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Hunter DJ; Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Karasik D; Harvard Medical School, Boston, MA 02115.; Hebrew SeniorLife Institute for Aging Research, Boston, MA., Kiel DP; Hebrew SeniorLife Institute for Aging Research, Boston, MA.; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115., Knight JA; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Kosma VM; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Kutalik Z; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Lai S; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy., Lambrechts D; Vesalius Research Center (VRC), VIB, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Mägi R; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Mannermaa A; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland., Martin NG; Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Masson G; deCODE Genetics, Reykjavik, Iceland., McArdle PF; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201., McArdle WL; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Melbye M; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.; Department of Medicine, Stanford School of Medicine, Stanford, USA., Michailidou K; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia., Milne RL; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Neven P; KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Belgium., Nohr EA; Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern denmark, DK., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Oostra BA; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Peacock M; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Peterlongo P; IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy., Peto J; Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK., Pharoah PD; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK., Postma DS; University Groningen, University Medical Center Groningen, Department Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, Groningen, The Netherlands., Pouta A; National Institute for Health and Welfare, Finland.; Department of Obstetrics and Gynecology, Oulu University Hospital, Finland., Pylkäs K; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland., Radice P; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Ring S; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Rivadeneira F; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215., Rudolph A; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Salomaa V; National Institute for Health and Welfare, Finland., Sanna S; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy., Schlessinger D; National Institute on Aging, Intramural Research Program, Baltimore, MD, USA., Schmidt MK; Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands., Southey MC; Department of Pathology, The University of Melbourne, Melbourne, Australia., Sovio U; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.; Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, United Kingdom., Stampfer MJ; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA., Stöckl D; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians- University, Munich, Germany., Storniolo AM; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Tyrer J; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK., Visser JA; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Vollenweider P; Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland., Völzke H; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany., Waeber G; Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Wallaschofski H; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany., Wang Q; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Willemsen G; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Winqvist R; Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland., Wolffenbuttel BH; Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands., Wright MJ; Queensland Insitute of Medical Research, Brisbane, Queensland, Australia., Boomsma DI; Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands., Econs MJ; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA.; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA., Khaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB2 0QQ, UK., Loos RJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1003, New York, NY 10029, USA., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK.; Oxford Centre for Diabetes, Endocrinology, & Metabolism, University of Oxford, Churchill Hospital, OX37LJ Oxford, UK., Montgomery GW; Queensland Insitute of Medical Research, Brisbane, Queensland, Australia., Rice JP; Dept. of Psychiatry, Washington University, St. Louis, MO 63110., Streeten EA; Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.; Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center, USA. Baltimore, MD 21201., Thorsteinsdottir U; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., van Duijn CM; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.; Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Centre of Medical Systems Biology, Leiden, the Netherlands., Alizadeh BZ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Bergmann S; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Boerwinkle E; Human Genetics Center and Div. of Epidemiology, University of Houston, TX., Boyd HA; Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark., Crisponi L; Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy., Gasparini P; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, Italy.; Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Harris TB; National Insitute on Aging, National Institutes of Health, Baltimore, MD 20892, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Järvelin MR; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.; Institute of Health Sciences, P.O.Box 5000, FI-90014 University of Oulu, Finland.; Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.; Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland., Kraft P; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., Lawlor D; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia., Pennell CE; School of Women's and Infants' Health, The University of Western Australia., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.; Harvard Medical School, Boston, MA 02115., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sørensen TI; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Strachan DP; Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK., Uitterlinden AG; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Widen E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland., Zygmunt M; Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany., Murray A; University of Exeter Medical School, University of Exeter, Exeter, UK EX1 2LU., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Murabito JM; NHLBI's and Boston University's Framingham Heart Study, Framingham, MA.; Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.; Department of Paediatrics,University of Cambridge,Cambridge,UK.
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Nature [Nature] 2014 Oct 02; Vol. 514 (7520), pp. 92-97. Date of Electronic Publication: 2014 Jul 23.
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Lango Allen H; Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK., Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, Mägi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM, Kettunen J, König IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon M, McKnight B, Morris AP, Müller M, Suh Ngwa J, Purcell S, Rafelt S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A, Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ, Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui J, Igl W, Illig T, Jula A, Kajantie E, Kilpeläinen TO, Koiranen M, Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML, Marusic A, Maschio A, Meitinger T, Mulas A, Paré G, Parker AN, Peden JF, Petersmann A, Pichler I, Pietiläinen KH, Pouta A, Ridderstråle M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO, Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S, Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall AS, Hamsten A, Huikuri HV, Iribarren C, Kähönen M, Kaprio J, Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimäki T, Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ, Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD, Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS, Stumvoll M, Tönjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM, Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Grönberg H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM, Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL, Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW, Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD, Völzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB, Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG, Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI, Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM, Hirschhorn JN
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Nature [Nature] 2010 Oct 14; Vol. 467 (7317), pp. 832-8. Date of Electronic Publication: 2010 Sep 29.
Autor:
Teslovich TM; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA., Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y, Lee JY, Park T, Kim K, Sim X, Twee-Hee Ong R, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Hua Zhao J, Yuan X, Luan J, Lamina C, Ziegler A, Zhang W, Zee RY, Wright AF, Witteman JC, Wilson JF, Willemsen G, Wichmann HE, Whitfield JB, Waterworth DM, Wareham NJ, Waeber G, Vollenweider P, Voight BF, Vitart V, Uitterlinden AG, Uda M, Tuomilehto J, Thompson JR, Tanaka T, Surakka I, Stringham HM, Spector TD, Soranzo N, Smit JH, Sinisalo J, Silander K, Sijbrands EJ, Scuteri A, Scott J, Schlessinger D, Sanna S, Salomaa V, Saharinen J, Sabatti C, Ruokonen A, Rudan I, Rose LM, Roberts R, Rieder M, Psaty BM, Pramstaller PP, Pichler I, Perola M, Penninx BW, Pedersen NL, Pattaro C, Parker AN, Pare G, Oostra BA, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, Meitinger T, McPherson R, McCarthy MI, McArdle W, Masson D, Martin NG, Marroni F, Mangino M, Magnusson PK, Lucas G, Luben R, Loos RJ, Lokki ML, Lettre G, Langenberg C, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, Kronenberg F, König IR, Khaw KT, Kaprio J, Kaplan LM, Johansson A, Jarvelin MR, Janssens AC, Ingelsson E, Igl W, Kees Hovingh G, Hottenga JJ, Hofman A, Hicks AA, Hengstenberg C, Heid IM, Hayward C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Gyllensten U, Guiducci C, Groop LC, Gonzalez E, Gieger C, Freimer NB, Ferrucci L, Erdmann J, Elliott P, Ejebe KG, Döring A, Dominiczak AF, Demissie S, Deloukas P, de Geus EJ, de Faire U, Crawford G, Collins FS, Chen YD, Caulfield MJ, Campbell H, Burtt NP, Bonnycastle LL, Boomsma DI, Boekholdt SM, Bergman RN, Barroso I, Bandinelli S, Ballantyne CM, Assimes TL, Quertermous T, Altshuler D, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Adair LS, Taylor HA Jr, Borecki IB, Gabriel SB, Wilson JG, Holm H, Thorsteinsdottir U, Gudnason V, Krauss RM, Mohlke KL, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJ, Schadt EE, Rotter JI, Boerwinkle E, Strachan DP, Mooser V, Stefansson K, Reilly MP, Samani NJ, Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, van Duijn CM, Peltonen L, Abecasis GR, Boehnke M, Kathiresan S
Publikováno v:
Nature [Nature] 2010 Aug 05; Vol. 466 (7307), pp. 707-13.