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Autor:
Maya Williams, Alexander Duncan, Richard M. O'Connor, Maria Vittoria Micioni Di Bonaventura, Zuxin Chen, Jessica L. Ables, Xin-An Liu, William M. Howe, Avi Ma'ayan, Mary P. Heyer, Paul J. Kenny, Qun Lu, Clementine Fillinger, Masago Ishikawa, Purva Bali, Theodore M. Kamenecka, Karim S. Elayouby, Inés Ibañez-Tallon, Zichen Wang, Aron M. Geurts, Stephanie P.B. Caligiuri, Heidi C. O'Neill
Publikováno v:
Nature. 574:372-377
Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain
Autor:
Lauren T. May, Rebecca F. Bhola, Ling Yeong Chia, Patrick M. Sexton, Apurba Bhattarai, Yinglong Miao, Celine Valant, Jinan Wang, Jens Carlsson, Christopher J Draper-Joyce, Kelly O’Sullivan, Hariprasad Venugopal, MacDonald J. Christie, Nicolas Panel, Alisa Glukhova, Denise Wootten, India Cowie-Kent, Anh Nguyen, David M. Thal, Paul J. White, Wendy L. Imlach, Arthur Christopoulos, Radostin Danev, Peter J. Scammells
Publikováno v:
Nature
The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain1,2. However, development of analgesic orthosteric A1R agonists has failed because of a lack of sufficient on-target selectivit
Autor:
Nan Li, Alan Jasanoff
Publikováno v:
Nature
The neurotransmitter dopamine is required for the reinforcement of actions by rewarding stimuli1. Neuroscientists have tried to define the functions of dopamine in concise conceptual terms2, but the practical implications of dopamine release depend o
Autor:
Sandy Ibanes, Brandon Weissbourd, Liqun Luo, Kevin T. Beier, Xiaojing J. Gao, Jing Ren, Robert C. Malenka, Kazunari Miyamichi, Eric J. Kremer, Lindsay A. Schwarz, Katherine E. DeLoach
Publikováno v:
Nature
To better understand the relationship between input and output connectivity for neurons of interest in specific brain regions, a viral-genetic tracing approach is used to identify input based on a combination of neurons’ projection and cell type, a
Autor:
Hui-Young Lee, Richard G. Kibbey, Derek M. Erion, Joao Paulo Camporez, Anila K. Madiraju, Yasmeen Rahimi, Xian-Man Zhang, Michael J. MacDonald, John L. Wood, Gary W. Cline, Gerald I. Shulman, Varman T. Samuel, Michael J. Jurczak, Demetrios T. Braddock, Brett J. Prigaro, Ronald A. Albright, Sanjay Bhanot
Publikováno v:
Nature. 510:542-546
Metformin is considered to be one of the most effective therapeutics for treating type 2 diabetes because it specifically reduces hepatic gluconeogenesis without increasing insulin secretion, inducing weight gain or posing a risk of hypoglycaemia. Fo
Autor:
Thierry T. Diagana, Suresh B. Lakshminarayana, Susan Noh, Francesca Blasco, Carrie F. Brooks, Jennifer A. Zambriski, Laura B. Goodman, Gu Feng, Sumiti Vinayak, Gillian T. Herbert, Peter Gedeck, Lijun Zhang, Jayesh Tandel, Siau H. Lim, Christian G. Noble, F. Joel Leong, Alex Chao, Juergen Wagner, Bin Zou, Boris Striepen, Tracy Sy, Ravinder Reddy Kondreddi, Christophe Bodenreider, Ujjini H. Manjunatha, Ghislain M. C. Bonamy, Adam Sateriale
Publikováno v:
Nature
Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly grave impact on infants and immunocompr
Autor:
Cassandra Willyard
Publikováno v:
Nature. 522:S53-S55
Addiction researchers are optimistic that they can create effective medication to treat addictions. But the key question is, will pharmaceutical companies bring them to market?
Autor:
Natasha N. Tirko, Patrick Bader, Richard W. Tsien, Gord Fishell, Sebnem N. Tuncdemir, Scott F. Owen
Publikováno v:
Nature
Neuromodulatory control by oxytocin is essential to a wide range of social, parental and stress-related behaviours. Autism spectrum disorders (ASD) are associated with deficiencies in oxytocin levels and with genetic alterations of the oxytocin recep
Publikováno v:
Nature
Nature, vol 471, iss 7340
Nature, vol 471, iss 7340
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying mechanisms are unknown. Here we report markedly increased nicotine intak
Autor:
Jeremy Clark, Huda Akil, Christina A. Akers, Leah M. Mayo, Ingo Willuhn, Paul E. M. Phillips, Shelly B. Flagel, Alayna Czuj, Terry E. Robinson, Sarah M. Clinton
Publikováno v:
Nature
Individuals make choices and prioritize goals using complex processes that assign value to rewards and associated stimuli. During Pavlovian learning, previously neutral stimuli that predict rewards can acquire motivational properties, whereby they th