Zobrazeno 1 - 10
of 970
pro vyhledávání: ''
Autor:
Angélica Torres-Berrío, Gareth M. Rurak, Mohammad J. Eslamizade, Natalina Salmaso, Danilo De Gregorio, Argel Aguilar-Valles, Agnieszka Skaleka, Martha Lopez-Canul, Nahum Sonenberg, Sara Bermudez, Jean-Claude Lacaille, Abdessattar Khlaifia, Gabriella Gobbi, Edna Matta-Camacho, Stephanie Simard
Publikováno v:
Nature. 590:315-319
Effective pharmacotherapy for major depressive disorder remains a major challenge, as more than 30% of patients are resistant to the first line of treatment (selective serotonin reuptake inhibitors)1. Sub-anaesthetic doses of ketamine, a non-competit
Autor:
Lauren T. May, Rebecca F. Bhola, Ling Yeong Chia, Patrick M. Sexton, Apurba Bhattarai, Yinglong Miao, Celine Valant, Jinan Wang, Jens Carlsson, Christopher J Draper-Joyce, Kelly O’Sullivan, Hariprasad Venugopal, MacDonald J. Christie, Nicolas Panel, Alisa Glukhova, Denise Wootten, India Cowie-Kent, Anh Nguyen, David M. Thal, Paul J. White, Wendy L. Imlach, Arthur Christopoulos, Radostin Danev, Peter J. Scammells
Publikováno v:
Nature
The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain1,2. However, development of analgesic orthosteric A1R agonists has failed because of a lack of sufficient on-target selectivit
Autor:
David M. Sabatini, Caroline A. Lewis, Elizaveta Freinkman, Tenzin Kunchok, Sze Ham Chan, Naama Kanarek, Lawrence D. Schweitzer, Jason R. Cantor, Heather R. Keys, Monther Abu-Remaileh
Publikováno v:
Nature
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by suppressing DNA and RNA producti
Publikováno v:
Nature
Nature, vol 555, iss 7695
Nature, vol 555, iss 7695
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion. Correspondingly, dysregulation of the dopaminergic system has been implicated in
Autor:
Daniel S. Peeper, Christian U. Blank, Hans W.M. Niessen, Julia Boshuizen, Thomas Kuilman, Aida Shahrabi, Ji Ying Song, Xiangjun Kong, Kristel Kemper, Marnix H Geukes Foppen, Elisa A. Rozeman
Publikováno v:
Nature, 550(7675), 270-274. Nature Publishing Group
Nature
Kong, X, Kuilman, T, Shahrabi, A, Boshuizen, J, Kemper, K, Song, J Y, Niessen, H W M, Rozeman, E A, Foppen, M H G, Blank, C U & Peeper, D S 2017, ' Cancer drug addiction is relayed by an ERK2-dependent phenotype switch ', Nature, vol. 550, no. 7675, pp. 270-274 . https://doi.org/10.1038/nature24037
Nature
Kong, X, Kuilman, T, Shahrabi, A, Boshuizen, J, Kemper, K, Song, J Y, Niessen, H W M, Rozeman, E A, Foppen, M H G, Blank, C U & Peeper, D S 2017, ' Cancer drug addiction is relayed by an ERK2-dependent phenotype switch ', Nature, vol. 550, no. 7675, pp. 270-274 . https://doi.org/10.1038/nature24037
Observations from cultured cells 1-3, animal models4 and patients5-7raise the possibility that the dependency of tumours on the therapeutic drugs to which they have acquired resistance represents a vulnerability with potential applications in cancer
Autor:
Hans Bitter, Sandra W. Cowan-Jacob, A. Quamrul Hassan, Silvia Buonamici, Andreas Marzinzik, Wolfgang Jahnke, Sanjeev Thohan, Jerry Donovan, Timothy P. Hughes, Wenjing Zhu, Andrew Wylie, Pascal Furet, Michael Palmer, Lilli Petruzzelli, Xavier Pelle, Susan Branford, Joseph Schoepfer, William R. Sellers, K. Gary Vanasse, Alice Loo, Nicholas Keen, Francesco Hofmann, Franco Lombardo, David M. Ross, Giuliano Berellini, Markus Warmuth, Stephanie Kay Dodd, Varsha Iyer
Publikováno v:
Nature. 543:733-737
Chronic myeloid leukaemia (CML) is driven by the activity of the BCR-ABL1 fusion oncoprotein. ABL1 kinase inhibitors have improved the clinical outcomes for patients with CML, with over 80% of patients treated with imatinib surviving for more than 10
Autor:
Craig J. Thomas, Manickavasagom Alkondon, Ruin Moaddel, Scott M. Thompson, Jonathan Fischell, Heather J. Pribut, Irving W. Wainer, Greg I. Elmer, Nagendra Singh, Patrick J. Morris, Yuhong Fang, Carlos A. Zarate, Todd D. Gould, Edson X. Albuquerque, Panos Zanos, Xi Ping Huang, Katina Sourou Sylvestre Dossou, Peixiong Yuan, Polymnia Georgiou, Cheryl L. Mayo
Publikováno v:
Nature
Major depressive disorder afflicts ~16 percent of the world population at some point in their lives. Despite a number of available monoaminergic-based antidepressants, most patients require many weeks, if not months, to respond to these treatments, a
Autor:
Robert Dreicer, Nima Sharifi, Mohammad Alyamani, Richard J. Auchus, Andrew C. Bishop, Zhenfei Li, Jorge A. Garcia, JJ Liu, Dustin R. Bunch, Sunil K. Upadhyay
Publikováno v:
Nature
Summary Prostate cancer resistance to castration occurs because tumors acquire the metabolic capability of converting precursor steroids to 5α-dihydrotestosterone (DHT), promoting signaling by the androgen receptor (AR) and the development of castra
Autor:
Ciarán N. Cronin, Jeffrey H. Chen, Eric Johnson, Gretchen A. Repasky, Michele McTigue, Peter A. Wells, Mika Kontro, Tea Pemovska, Kimmo Porkka, Olli Kallioniemi, Brion W. Murray, Krister Wennerberg
Publikováno v:
Nature. 519:102-105
The BCR-ABL1 fusion gene is a driver oncogene in chronic myeloid leukaemia and 30-50% of cases of adult acute lymphoblastic leukaemia. Introduction of ABL1 kinase inhibitors (for example, imatinib) has markedly improved patient survival, but acquired
Autor:
James Mitchell Crow
Publikováno v:
Nature. 535:S4-S6
The dearth of treatment options for chronic pain has led to widespread over-prescription of strong opioids. But some innovative thinking is building a promising pipeline.