Zobrazeno 1 - 10
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pro vyhledávání: ''
Autor:
Lauren T. May, Rebecca F. Bhola, Ling Yeong Chia, Patrick M. Sexton, Apurba Bhattarai, Yinglong Miao, Celine Valant, Jinan Wang, Jens Carlsson, Christopher J Draper-Joyce, Kelly O’Sullivan, Hariprasad Venugopal, MacDonald J. Christie, Nicolas Panel, Alisa Glukhova, Denise Wootten, India Cowie-Kent, Anh Nguyen, David M. Thal, Paul J. White, Wendy L. Imlach, Arthur Christopoulos, Radostin Danev, Peter J. Scammells
Publikováno v:
Nature
The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain1,2. However, development of analgesic orthosteric A1R agonists has failed because of a lack of sufficient on-target selectivit
Autor:
Henrik Antti, Jeremy K. Nicholson, Gilles Hanton, T. Andrew Clayton, Jean-Pierre Provost, Rosalind Walley, Jeremy R. Everett, Jean-Loic Le Net, Olivier Cloarec, David Baker, John C. Lindon, Claude Charuel
Publikováno v:
Nature. 440:1073-1077
There is a clear case for drug treatments to be selected according to the characteristics of an individual patient, in order to improve efficacy and reduce the number and severity of adverse drug reactions1,2. However, such personalization of drug tr
Publikováno v:
Nature. 437:1027-1031
Drugs of abuse are known to cause persistent modification of neural circuits, leading to addictive behaviours. Changes in synaptic plasticity in dopamine neurons of the ventral tegmental area (VTA) may contribute to circuit modification induced by ma
Autor:
Ruey-Bing Yang, Alan T. Nurden, Pamela B. Conley, Georgia Li, Paquita Nurden, Diana Vincent, David Julius, Gunther Hollopeter, Hans-Michael Jantzen, Laura J. England, Vanitha Ramakrishnan
Publikováno v:
Nature. 409:202-207
Platelets have a crucial role in the maintenance of normal haemostasis, and perturbations of this system can lead to pathological thrombus formation and vascular occlusion, resulting in stroke, myocardial infarction and unstable angina. ADP released
Autor:
Camille G. Wermuth, André Mann, F. Sautel, Sylvie Perachon, Barry J. Everitt, Maria Pilla, Pierre Sokoloff, Fabrice Garrido, Jean-Charles Schwartz
Publikováno v:
Nature. 400:371-375
Environmental stimuli that are reliably associated with the effects of many abused drugs, especially stimulants such as cocaine, can produce craving and relapse in abstinent human substance abusers. In animals, such cues can induce and maintain drug-
Publikováno v:
Nature. 393:76-79
Tobacco smoking is a worldwide public health problem. In the United States alone, over 400,000 deaths and $50 billion in medical costs annually are directly attributed to smoking. Accumulated evidence indicates that nicotine is the component of tobac
Publikováno v:
Nature. 389:382-385
The analgesic effect of clinically used exogenous opioids, such as morphine, is mediated primarily through mu-opioid receptors, but the function of the kappa-receptor in opioid analgesia is unclear. Although kappa-receptor agonists can produce analge
Autor:
George F. Koob, M. R. A. Carrera, Kim D. Janda, Peter Wirsching, Jon A. Ashley, Loren H. Parsons
Publikováno v:
Nature. 378:727-730
COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization1,2 to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system
Autor:
William N. Charman, Jonathan L. Vennerstrom, Susan A. Charman, Jacques Chollet, Josefina Santo Tomas, Kylie Anne McIntosh, Yuanqing Tang, Hugues Matile, Yuxiang Dong, Maniyan Padmanilayam, Daniel Hunziker, Sergio Wittlin, Bernard Scorneaux, Sarah Arbe-Barnes, Reto Brun, Heinrich Urwyler, Francis C. K. Chiu, Christian Scheurer, Arnulf Dorn
Publikováno v:
Nature. 430(7002)
The discovery of artemisinin more than 30 years ago provided a completely new antimalarial structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1,2,4-trioxane heterocycle. Available evidence suggests that artemisi
Publikováno v:
Nature. 417(6886)
Lithium, carbamazepine and valproic acid are effective mood-stabilizing treatments for bipolar affective disorder. The molecular mechanisms underlying the actions of these drugs and the illness itself are unknown. Berridge and colleagues suggested th