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Autor:
Nan Li, Alan Jasanoff
Publikováno v:
Nature
The neurotransmitter dopamine is required for the reinforcement of actions by rewarding stimuli1. Neuroscientists have tried to define the functions of dopamine in concise conceptual terms2, but the practical implications of dopamine release depend o
Autor:
Lawrence J. Druhan, Tse-Yao Wang, Saradhadevi Varadharaj, Craig Hemann, Yeong Renn Chen, Levy Reyes, M.A. Hassan Talukder, Chun-An Chen, Jay L. Zweier
Publikováno v:
Nature. 468:1115-1118
Endothelial nitric oxide synthase (eNOS) is critical in the regulation of vascular function, and can generate both nitric oxide (NO) and superoxide (O(2)(•-)), which are key mediators of cellular signalling. In the presence of Ca(2+)/calmodulin, eN
Publikováno v:
Nature
Nicotine addiction begins with high-affinity binding of nicotine to acetylcholine (ACh) receptors in the brain. The end result is over 4,000,000 smoking-related deaths annually worldwide and the largest source of preventable mortality in developed co
Autor:
Yingxi Lin, Ariya D. Lapan, Athar N. Malik, Michael E. Greenberg, Linda Hu, Brenda L. Bloodgood, Jessica L. Hauser, Tae Kyung Kim, Alex Chun Koon
Publikováno v:
Nature. 455:1198-1204
Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, l
Autor:
Jesus Bertran-Gonzalez, Odile Filhol, Hervé Enslen, Jean-Antoine Girault, Miriam Matamales, Angus C. Nairn, Denis Hervé, Matthieu Maroteaux, Karen Brami-Cherrier, Paul Greengard, Emmanuel Valjent, Jung Hyuck Ahn, Anne Gaëlle Corbillé, Alexandre Stipanovich, Akinori Nishi
Publikováno v:
Nature
Nature, 2008, 453 (7197), pp.879. ⟨10.1038/nature06994⟩
Nature, Nature Publishing Group, 2008, 453 (7197), pp.879. ⟨10.1038/nature06994⟩
Nature, 2008, 453 (7197), pp.879. ⟨10.1038/nature06994⟩
Nature, Nature Publishing Group, 2008, 453 (7197), pp.879. ⟨10.1038/nature06994⟩
Article; International audience; Dopamine orchestrates motor behaviour and reward-driven learning. Perturbations of dopamine signalling have been implicated in several neurological and psychiatric disorders, and in drug addiction. The actions of dopa
Autor:
Juha Lauren, Jaan-Olle Andressoo, Mart Saarma, Raimo K. Tuominen, Johan Peränen, Veli-Matti Leppänen, Merja H. Voutilainen, Nisse Kalkkinen, Tõnis Timmusk, Maria Lindahl, Päivi Lindholm, Sanna Janhunen
Publikováno v:
Nature. 448:73-77
In Parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing and adult vertebrate nervous system. The most potent n
Publikováno v:
Nature. 437:1027-1031
Drugs of abuse are known to cause persistent modification of neural circuits, leading to addictive behaviours. Changes in synaptic plasticity in dopamine neurons of the ventral tegmental area (VTA) may contribute to circuit modification induced by ma
Publikováno v:
Nature. 422:614-618
The dopamine-containing projection from the ventral tegmental area of the midbrain to the nucleus accumbens is critically involved in mediating the reinforcing properties of cocaine. Although neurons in this area respond to rewards on a subsecond tim
Autor:
J. Amiel Rosenkranz, Anthony A. Grace
Publikováno v:
Nature. 417:282-287
Pavlovian conditioning results when an innocuous stimulus, such as an odour, is paired with a behaviourally relevant stimulus, such as a foot-shock, so that eventually the former stimulus alone will elicit the behavioural response of the latter. The
Autor:
Jorge Diaz, Pierre Sokoloff, Nathalie Griffon, Patrick Carroll, Jean-Charles Schwartz, Olivier Guillin
Publikováno v:
Nature. 411:86-89
Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptidic factor initially regarded to be responsible for neuron proliferation, differentiation and survival, through its uptake at nerve terminals and retrograde transport t