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Autor:
Masamitsu Nakazato, Kenji Kangawa, Masayasu Kojima, Yukari Date, Hisayuki Matsuo, Hiroshi Hosoda
Publikováno v:
Nature. 402:656-660
Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through GHS-R, a G-protein-coupled receptor for which the ligand is unknown. Recent cloning of GHS-R strong
Publikováno v:
Nature. 383:713-716
Nicotine obtained from tobacco can improve learning and memory on various tasks and has been linked to arousal, attention, rapid information processing, working memory, and long-term memories that can cause craving years after someone has stopped smo
Autor:
Pierre Sokoloff, J.-C. Schwartz, Daniele Piomelli, Marie-Pascale Martres, C. Pilon, Bruno Giros
Publikováno v:
Nature. 353(6340)
Understanding the actions of the neurotransmitter dopamine in the brain is important in view of its roles in neuropsychiatric illnesses. Dopamine D1 receptors, which stimulate both adenylyl cyclase and phospholipase C, and D2 receptors, which inhibit
Autor:
Jack D. Barchas, Robert L. Patrick
Publikováno v:
Nature. 250:737-739
ISOLATED synaptosomal preparations maintain many of the functional properties of intact neurones1 and the uptake of putativebiogenicamine neurotransmitters such as noradrenaline, dopamine and serotonin, is well documented2–5. In addition, stimulati
Publikováno v:
Nature. 278:63-65
EXTRACELLULAR Ca ions are required for the secretion of many hormones1. In the adrenal medulla catecholamine secretion evoked by acetylcholine (ACh) is completely blocked by omitting Ca from the medium2,3. The mechanism for Ca entry has been studied
Publikováno v:
Nature. 277:484-486
IT was reported by Mela1,2 that local anaesthetics stimulate Ca2+ uptake by rat liver mitochondria. This has been attributed to the protective action of these compounds on mitochondrial structure3,4, particularly with regard to inhibition of phosphol
Publikováno v:
Nature. 321:698-700
Several investigators have shown that tumour promoter phorbol esters mimic the effects of endogenous diacylglycerol to activate a second messenger, protein kinase C (refs 1–3). These phorbol esters have proved to be valuable tools for exploring the
Publikováno v:
Nature. 268:652-654
THE firing rate of the dopaminergic neurones in the substantia nigra (s. nigra) of mammalian brain is controlled largely by descending striatonigral neurones. But new evidence suggests that the activity of nigral neurones may also be modulated by loc
Autor:
Joachim K. Krauss, Dieter K. Meyer
Publikováno v:
Nature. 301(5898)
Peptides of the cholecystokinin family, but mainly the sulphated octapeptide (CCK8), have been found in brain extracts of several species1–6. High amounts are present in axons and nerve endings in the rat neostriatum (caudate-putamen)7,8 and a role
Publikováno v:
Nature. 265(5596)
SMOOTH muscle tone seems to be primarily regulated by the concentration of free calcium in cytoplasm1,2. Several agents that cause smooth muscle contraction increase the tissue content of cyclic GMP with no significant change or only small reduction