Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bernd Epe"'
Publikováno v:
Mutation research. 625(1-2)
Mitochondrial DNA (mtDNA) is assumed to be highly prone to damage by reactive oxygen species (ROS) because of its location in close proximity to the mitochondrial electron transport chain. Accordingly, mitochondrial oxidative DNA damage has been hypo
Autor:
Susanne, Brendler-Schwaab, Andreas, Czich, Bernd, Epe, Elmar, Gocke, Bernd, Kaina, Lutz, Müller, Dieter, Pollet, Dietmar, Utesch
Publikováno v:
Mutation research. 566(1)
In recent years, assessing the photogenotoxic potential of a compound became an issue for certain drugs and cosmetical products. Therefore, existing methods performed according to international guidelines (e.g. OECD guidelines) were adapted to the us
Autor:
Ina Schulz, Hanns-Christian Mahler, Chantu R. Saha-Möller, Bernd Epe, Waldemar Adam, Günther N. Grimm
Publikováno v:
Mutation research. 461(4)
Like hydroxyl radicals, alkoxyl radicals have been implicated in the generation of cellular oxidative DNA damage under physiological conditions; however, their genotoxic potential has not yet been established. We have analyzed the DNA damage induced
Publikováno v:
Mutation research. 461(2)
We have analyzed the recognition by various repair endonucleases of DNA base modifications induced by three oxidants, viz. [4-(tert-butyldioxycarbonyl)benzyl]triethylammonium chloride (BCBT), a photochemical source of tert-butoxyl radicals, disodium
Autor:
Elmar Gocke, Hanns-Christian Mahler, Inge Eckert, Michael Pflaum, Olaf Will, Bernd Epe, Ina Schulz
Publikováno v:
Mutation research. 435(1)
The oxidative DNA damage induced by the polar photosensitizer Ro19-8022 in the presence of light was studied and correlated with the associated mutagenicity. Both in isolated DNA and AS52 Chinese hamster ovary cells, photoexcited Ro19-8022 gave rise
Publikováno v:
Mutation research. 299(3-4)
The specific recognition of DNA modifications by repair endonucleases was used to characterize the DNA damage induced by photosensitizers in the presence of visible light. Under cell-free conditions, chemically unrelated photosensitizers (methylene b