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Publikováno v:
mSphere
mSphere, Vol 6, Iss 3 (2021)
mSphere, Vol 6, Iss 3 (2021)
Pseudomonas aeruginosa is a multidrug-resistant, opportunistic pathogen that frequently causes ventilator-associated pneumonia in intensive care units and chronic lung infections in cystic fibrosis patients. The rising prevalence of drug-resistant ba
Autor:
Ørjan Samuelsen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Christopher Fröhlich, Viivi H. A. Hirvonen, Bjarte Aarmo Lund, Marc W. van der Kamp, Klaus Harms, João Alves Gama
Publikováno v:
mSphere
mSphere, Vol 6, Iss 2 (2021)
Fröhlich, C, Hirvonen, V H A & Van Der Kamp, M W 2021, ' Cryptic β-lactamase evolution is driven by low β-lactam concentrations ', mSphere, vol. 6, no. 2, e00108-21 . https://doi.org/10.1128/mSphere.00108-21
mSphere, Vol 6, Iss 2 (2021)
Fröhlich, C, Hirvonen, V H A & Van Der Kamp, M W 2021, ' Cryptic β-lactamase evolution is driven by low β-lactam concentrations ', mSphere, vol. 6, no. 2, e00108-21 . https://doi.org/10.1128/mSphere.00108-21
Very low antibiotic concentrations have been shown to drive the evolution of antimicrobial resistance. While substantial progress has been made to understand the driving role of low concentrations during resistance development for different antimicro
Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible Pseudomonas aeruginosa
Autor:
Cheng Yee Tang, Andrea L. Kwa, Rick Twee-Hee Ong, Jie Chong Lim, Si Hui Tan, Jocelyn Qi-Min Teo, Shannon Jing-Yi Lee, James Heng Chiak Sim
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
mSphere
mSphere
Pseudomonas aeruginosa infection is one of the most difficult health care-associated infections to treat due to the ability of the organism to acquire a multitude of resistance mechanisms and express the multidrug resistance phenotype. Ceftolozane/ta
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
mSphere
mSphere, vol 5, iss 6
mSphere
mSphere, vol 5, iss 6
Candida albicans is one of the most common pathogens of humans. One important virulence factor of C. albicans is its ability to form elongated hyphae that can invade host tissues and cause disseminated infections. Here, we show the effect of differen
Autor:
Sabrina Jenull, Rounik Mazumdar, Anuradha Chowdhary, Anton Stoiber, Karl Kuchler, Ashutosh Singh, Manju Chauhan, Filomena Nogueira, Neeraj Chauhan, Raju Shivarathri
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
mSphere
mSphere
Candida auris is an emerging multidrug-resistant (MDR) fungal pathogen that presents a serious global threat to human health. The Centers for Disease Control and Prevention (CDC) have classified C. auris as an urgent threat to public health for the n
Publikováno v:
mSphere
mSphere, 5 (4)
mSphere, Vol 5, Iss 4, p e00423-20 (2020)
mSphere, Vol 5, Iss 4 (2020)
mSphere, 5 (4)
mSphere, Vol 5, Iss 4, p e00423-20 (2020)
mSphere, Vol 5, Iss 4 (2020)
Understanding how animal influenza viruses can adapt to spread in humans is critical to prepare for, and prevent, new pandemics. However, working safely with pathogens that have pandemic potential requires tight regulation and the use of high-level p
Autor:
Kalyan D. Chavda, Jie Wei, Barry N. Kreiswirth, Liang Chen, Siqiang Niu, Puneet Dhawan, Steven H. Marshall, Robert A. Bonomo, Chunhong Zou, Deqiang Wang
Publikováno v:
mSphere
mSphere, Vol 5, Iss 4, p e00775-20 (2020)
mSphere, Vol 5, Iss 4 (2020)
mSphere, Vol 5, Iss 4, p e00775-20 (2020)
mSphere, Vol 5, Iss 4 (2020)
KPC is currently the most common carbapenemase identified in the United States. More than 40 KPC variants have been described, of which KPC-2 and KPC-3 are the most frequent clinical variants. However, our understanding of the genetic structures and
Autor:
Anna C. Zemke, Naomi S. Kasturiarachi, Emily C. Snell, Jennifer M. Bomberger, Angela M. Torres, Emily J. D’Amico
Publikováno v:
mSphere, Vol 5, Iss 4, p e00630-20 (2020)
mSphere
mSphere, Vol 5, Iss 4 (2020)
mSphere
mSphere, Vol 5, Iss 4 (2020)
During chronic lung infections, Pseudomonas aeruginosa grows in highly antibiotic-tolerant communities called biofilms that are difficult for the host to clear. We have developed models for studying P. aeruginosa biofilm dispersal in environments tha
Publikováno v:
mSphere
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
mSphere, Vol 5, Iss 3, p e00365-20 (2020)
mSphere, Vol 5, Iss 3 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
mSphere, Vol 5, Iss 3, p e00365-20 (2020)
mSphere, Vol 5, Iss 3 (2020)
Aspergillus fumigatus is an opportunistic human-pathogenic fungus causing allergic reactions or systemic infections, such as invasive pulmonary aspergillosis in immunocompromised patients. Caspofungin is an echinocandin that impacts the construction
Publikováno v:
mSphere
mSphere, Vol 5, Iss 3 (2020)
mSphere, Vol 5, Iss 3, p e00374-20 (2020)
mSphere, Vol 5, Iss 3 (2020)
mSphere, Vol 5, Iss 3, p e00374-20 (2020)
The folate biosynthetic pathway is a promising and understudied source for novel antifungals. Even dihydrofolate reductase (DHFR), a well-characterized and historically important drug target, has not been conclusively validated as an antifungal targe