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Autor:
Hillary M. Struthers, Wilma Perez, Lindsey B. Crawford, Patrizia Caposio, Meaghan H. Hancock, Jennifer L. Mitchell
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
mSphere
mSphere
Human cytomegalovirus (HCMV) causes serious disease in immunocompromised individuals and is a significant problem during transplantation. The virus can establish a latent infection in CD34+ hematopoietic progenitor cells (HPCs) and periodically react
Autor:
David R. Hill, Sha Huang, Madeline R. Barron, Veda K. Yadagiri, Roberto J. Cieza, Vincent B. Young, Jason R. Spence
Publikováno v:
mSphere
mSphere, Vol 5, Iss 6 (2020)
mSphere, Vol 5, Iss 6 (2020)
Technological advancements have driven and will continue to drive the adoption of organotypic systems for investigating host-microbe interactions within the human intestinal ecosystem. Using E. coli deficient in the RpoS-mediated general stress respo
Publikováno v:
mSphere, Vol 5, Iss 2, p e00031-20 (2020)
mSphere, Vol 5, Iss 2 (2020)
mSphere
mSphere, Vol 5, Iss 2 (2020)
mSphere
Chronic Toxoplasma gondii infection is maintained in the central nervous system by thick-walled cysts. If host immunity wanes, cysts recrudesce and cause severe and often lethal toxoplasmic encephalitis. Currently, there are no therapies to eliminate
Autor:
Suhas Sureshchandra, Sharmila Mallya, Armond L. Franklin-Murray, Allen Jankeel, Ilhem Messaoudi, Melissa B. Lodoen
Publikováno v:
mSphere
mSphere, Vol 5, Iss 1, p e00550-19 (2020)
mSphere, Vol 5, Iss 1 (2020)
mSphere, Vol 5, Iss 1, p e00550-19 (2020)
mSphere, Vol 5, Iss 1 (2020)
Toxoplasma gondii is a foodborne parasite that infects virtually all warm-blooded animals and can cause severe disease in individuals with compromised or weakened immune systems. During dissemination in its infected hosts, T. gondii breaches endothel
Autor:
Terence C. Theisen, Alma G. Mendoza, Alicja M. Cygan, Michael W. Panas, Nicole D. Marino, John C. Boothroyd
Publikováno v:
mSphere, Vol 5, Iss 1, p e00858-19 (2020)
mSphere, Vol 5, Iss 1 (2020)
mSphere
mSphere, Vol 5, Iss 1 (2020)
mSphere
Toxoplasma is an extremely successful intracellular parasite and important human pathogen. Upon infection of a new cell, Toxoplasma establishes a replicative vacuole and translocates parasite effectors across this vacuole to function from the host cy
Publikováno v:
mSphere
mSphere, Vol 4, Iss 3, p e00292-19 (2019)
mSphere, Vol 4, Iss 3 (2019)
mSphere, Vol 4, Iss 3, p e00292-19 (2019)
mSphere, Vol 4, Iss 3 (2019)
Toxoplasma gondii is a single-celled parasite that has infected up to one-third of the world’s population. Significant overhauls in gene expression in both the parasite and the host cell accompany parasite invasion, and a better understanding of th
Autor:
Luis H. Franco, Sujittra Chaisavaneeyakorn, Bethany A. Weigele, Michael U. Shiloh, Chelsea E. Stamm, Neal M. Alto, Breanna L. Pasko, Vidhya Nair
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
mSphere, Vol 4, Iss 3, p e00354-19 (2019)
mSphere
mSphere, Vol 4, Iss 3, p e00354-19 (2019)
mSphere
Advances have been made to identify secreted proteins of Mycobacterium tuberculosis during animal infections. These data, combined with transposon screens identifying genes important for M. tuberculosis virulence, have generated a vast resource of po
Publikováno v:
mSphere
mSphere, Vol 4, Iss 3, p e00142-19 (2019)
mSphere, Vol 4, Iss 3 (2019)
mSphere, Vol 4, Iss 3, p e00142-19 (2019)
mSphere, Vol 4, Iss 3 (2019)
Selective delivery of small molecules into intracellular parasites is particularly problematic due to the presence of multiple membranes and surrounding host cells. We have devised a method that can deliver caged molecules into an intracellular paras
Publikováno v:
mSphere, Vol 4, Iss 3, p e00077-19 (2019)
mSphere, Vol 4, Iss 3 (2019)
mSphere
mSphere, Vol 4, Iss 3 (2019)
mSphere
Nearly half a million deaths were attributed to malaria in 2017. Protozoan parasites of the genus Plasmodium cause disease in humans while replicating asexually within the host’s erythrocytes, with P. falciparum responsible for most of the mortalit
Autor:
Yolanda Calle, Volker Behrends, Luis M. Mateos, Natalia Bravo-Santano, James K. Ellis, Hector C. Keun, Michal Letek
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
mSphere, Vol 3, Iss 4, p e00374-18 (2018)
mSphere
mSphere, Vol 3, Iss 4, p e00374-18 (2018)
mSphere
Staphylococcus aureus escapes from immune recognition by invading a wide range of human cells. Once the pathogen becomes intracellular, the most important last resort antibiotics are not effective. Therefore, novel anti-infective therapies against in