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Autor:
Abdur Rashid, Mohsin Kazi, Mohammad H. Shariare, Mohammed S. Aldughaim, Saeed Ali Syed, Ahmed Bari
Publikováno v:
Molecules, Vol 26, Iss 15, p 15 (2021)
Molecules
Volume 26
Issue 1
Molecules
Volume 26
Issue 1
In recent years, indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities—antibacterial, antiviral, and anticonvulsant. This compound is derived from naturally grown plants. Therefore, synthesis
Publikováno v:
Molecules, Vol 26, Iss 137, p 137 (2021)
Molecules
Volume 26
Issue 1
Molecules
Volume 26
Issue 1
In this study, catechin (CTN) isolated from Elaeagnus umbellata was evaluated for in vitro antioxidant potential and inhibition of carbohydrate digestive enzymes (&alpha
amylase and &alpha
glucosidase). The compound was also tested for its
amylase and &alpha
glucosidase). The compound was also tested for its
Publikováno v:
Molecules, Vol 26, Iss 86, p 86 (2021)
Cancer is the second leading cause of death globally with an estimated 9.6 million deaths in 2018 and a sustained rise in its incidence in both developing and developed countries. According to the WHO, about 1 in 6 deaths is due to cancer. Despite th
Publikováno v:
Molecules, Vol 26, Iss 5, p 5 (2021)
Molecules
Molecules
Andrographolide is a labdane diterpene and the main active ingredient isolated from the herb Andrographis paniculata. Andrographolide possesses diverse biological effects including anti-inflammatory, antioxidant, and antineoplastic properties. Clinic
Publikováno v:
Molecules, Vol 26, Iss 2, p 2 (2021)
Molecules
Molecules; Volume 26; Issue 1; Pages: 2
Molecules
Molecules; Volume 26; Issue 1; Pages: 2
Degradation of anthocyanins involves scission of the flavonoid skeleton yielding 2,4,6-trihydroxybenzaldehyde (phloroglucinaldehyde, PGA) and a phenolic acid. However, the process is not finished with the formation of PGA, as the consequent condensat
Publikováno v:
Molecules, Vol 26, Iss 176, p 176 (2021)
Molecules
Volume 26
Issue 1
Molecules
Volume 26
Issue 1
A series of multi-substituted isatin derivatives were synthesized using the powerful Sandmeyer reaction. The structures of these derivatives were confirmed by 1H-NMR, 13C-NMR, and HR-MS. Inhibition of proliferation activities of these derivatives aga
Publikováno v:
Biomolecules
Volume 10
Issue 4
Biomolecules, MDPI, 2020, 10 (4), pp.579. ⟨10.3390/biom10040579⟩
Biomolecules, Vol 10, Iss 579, p 579 (2020)
Volume 10
Issue 4
Biomolecules, MDPI, 2020, 10 (4), pp.579. ⟨10.3390/biom10040579⟩
Biomolecules, Vol 10, Iss 579, p 579 (2020)
International audience; A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine
Publikováno v:
Molecules, Vol 26, Iss 6490, p 6490 (2021)
Molecules
Volume 26
Issue 21
Molecules
Volume 26
Issue 21
As cancer remains one of the major health burdens worldwide, novel agents, due to the development of resistance, are needed. In this work, we designed and synthesized harmirins, which are hybrid compounds comprising harmine and coumarin scaffolds, ev
Autor:
Pascal Bonnet, Philippe Morin, Marie-Lise Jourdan, Reine Nehmé, Hélène Bénédetti, Marie Aude Hiebel, Sylvain Routier, Rémy Le Guével, Béatrice Vallée, Justine Corret, Nathalie Percina, Frédéric Buron, Stéphane Bourg, Thibault Saurat, Nuno Rodrigues
Publikováno v:
Molecules, Vol 26, Iss 5349, p 5349 (2021)
Molecules
Molecules, MDPI, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Volume 26
Issue 17
Molecules
Molecules, MDPI, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Volume 26
Issue 17
International audience; This work describes the synthesis, enzymatic activities on PI3K and mTOR, in silico docking and cellular activities of various uncommon 2,4,7 trisubstituted pyrido[3,2-d]pyrimidines. The series synthesized offers a chemical di
Autor:
Joanna Izabela Lachowicz, Mariusz Jaremko, Charlotte A. E. Hauser, Mawadda Alghrably, Marcello Campagna, Sherin Abdelrahman
Publikováno v:
Molecules
Volume 26
Issue 16
Molecules, Vol 26, Iss 4730, p 4730 (2021)
Volume 26
Issue 16
Molecules, Vol 26, Iss 4730, p 4730 (2021)
Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects. Diabetes is