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Publikováno v:
Molecules, Vol 26, Iss 5, p 5 (2021)
Molecules
Molecules
Andrographolide is a labdane diterpene and the main active ingredient isolated from the herb Andrographis paniculata. Andrographolide possesses diverse biological effects including anti-inflammatory, antioxidant, and antineoplastic properties. Clinic
Publikováno v:
Molecules
Volume 26
Issue 16
Molecules, Vol 26, Iss 4733, p 4733 (2021)
Volume 26
Issue 16
Molecules, Vol 26, Iss 4733, p 4733 (2021)
Berberine (BBR), a plant alkaloid, is known for its therapeutic properties of anticancer, cardioprotective, antidiabetic, hypolipidemic, neuroprotective, and hepatoprotective activities. The present study was to determine the molecular mechanism of B
Publikováno v:
Molecules
Volume 26
Issue 15
Molecules, Vol 26, Iss 4516, p 4516 (2021)
Volume 26
Issue 15
Molecules, Vol 26, Iss 4516, p 4516 (2021)
Despite many advances in therapy, glioblastoma (GB) is still characterized by its poor prognosis. The main reason for this is unsuccessful treatment, which slightly extends the duration of remission
thus, new regimens are needed. One of many typ
thus, new regimens are needed. One of many typ
Autor:
Manoj K. Pandey, Amit K. Tiwari, Manivannan Elangovan, Noor Hussein, N.S. Hari Narayana Moorthy, Rahul Patidar, Karthikeyan Chandrabose, Kyle McIntosh, Saloni Malla, Piyush Trivedi, Dayanidhi Raman, Jenna M. Len
Publikováno v:
Molecules
Volume 26
Issue 14
Molecules, Vol 26, Iss 4214, p 4214 (2021)
Volume 26
Issue 14
Molecules, Vol 26, Iss 4214, p 4214 (2021)
In this study, we designed, synthesized and evaluated, in vitro, novel chalcone analogs containing dialkylamino pharmacophores in the cervical cancer cell line, OV2008. The compound, DML6 was selective and significantly decreased the proliferation of
Publikováno v:
Molecules, Vol 26, Iss 4658, p 4658 (2021)
Molecules
Volume 26
Issue 15
Molecules
Volume 26
Issue 15
Recently, we designed an inventive paradigm in nanomedicine—drug-free macromolecular therapeutics (DFMT). The ability of DFMT to induce apoptosis is based on biorecognition at cell surface, and crosslinking of receptors without the participation of
Publikováno v:
Molecules, Vol 26, Iss 4333, p 4333 (2021)
Molecules
Molecules
Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature re
Publikováno v:
Molecules
Molecules, Vol 26, Iss 4100, p 4100 (2021)
Molecules, Vol 26, Iss 4100, p 4100 (2021)
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its high incidence, the clinical management of the disease remains a major challenge. Several reports have documented a relationship between the phosphatidylinositol-
Autor:
Raghavendra G. Amachawadi, Gopenath Thangaraj Saradha, Asad Syed, Parthiban Rudrapathy, Sharanagouda S. Patil, Deepthi Venkatachalapathy, Shiva Prasad Kollur, Chandan Shivamallu, Ali H. Bahkali, Abdallah M. Elgorban, Shashanka K. Prasad, Kanthesh M. Basalingappa
Publikováno v:
Molecules
Molecules, Vol 26, Iss 4593, p 4593 (2021)
Volume 26
Issue 15
Molecules, Vol 26, Iss 4593, p 4593 (2021)
Volume 26
Issue 15
The edible parts of the plants Camellia sinensis, Vitis vinifera and Withania somnifera were extensively used in ancient practices such as Ayurveda, owing to their potent biomedical significance. They are very rich in secondary metabolites such as po
Ziziphus nummularia Attenuates the Malignant Phenotype of Human Pancreatic Cancer Cells: Role of ROS
Autor:
Mesmar, J., Mesmar, Joelle, Fardoun, Manal M., Abdallah, Rola, Al Dhaheri, Yusra, Yassine, Hadi M., Iratni, Rabah, Badran, Adnan, Eid, Ali H., Baydoun, Elias
Publikováno v:
Molecules
Volume 26
Issue 14
Molecules, Vol 26, Iss 4295, p 4295 (2021)
Volume 26
Issue 14
Molecules, Vol 26, Iss 4295, p 4295 (2021)
Pancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need for alternative approaches, including herbal medicine. Among
Publikováno v:
Molecules
Volume 26
Issue 13
Molecules, Vol 26, Iss 3915, p 3915 (2021)
Volume 26
Issue 13
Molecules, Vol 26, Iss 3915, p 3915 (2021)
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Studies have shown that bradykinin (BK) is highly expressed in liver cancer. We designed the novel BK receptor inhibitors J051-71 and J051-105, which reduced the viability of l