Zobrazeno 1 - 2
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pro vyhledávání: '"Carmen Garnacho"'
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(7)
Acid sphingomyelinase deficiency in type B Niemann-Pick disease leads to lysosomal sphingomyelin storage, principally affecting lungs, liver, and spleen. Infused recombinant enzyme is beneficial, yet its delivery to the lungs is limited and requires
Autor:
Carmen Garnacho, John Leferovich, Edward H. Schuchman, Christine Gajewski, Julie A. Champion, Vladimir R. Muzykantov, Samir Mitragotri, Silvia Muro
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 16(8)
Endocytosis in endothelial cells (ECs) is important for many biomedical applications, including drug delivery by nano- and microscale carriers. However, little is known about how carrier geometry influences endothelial drug targeting, intracellular t