Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Feijie Zhang"'
Publikováno v:
Molecular Therapy. 21:954-963
The bacterial backbone (BB) sequences contained within a canonical plasmid DNA dampen exogenous transgene expression by tenfold to 1,000-fold over a period of a few weeks following transfection into quiescent tissues such as the liver. Minicircle DNA
Publikováno v:
Molecular Therapy. 20(11):2111-2119
In quiescent tissues, minicircle DNA vectors provide at least 10 times higher sustained levels of transgene expression compared to that achieved with a canonical plasmid containing the same expression cassette. It is not known if there is a specific
Autor:
Shuo Gu, Paul N. Valdmanis, Huban Kutay, Lan Jin, Kirk Chu, Feijie Zhang, Mark A. Kay, Yong Huang, Elizabeth M. Munding, Yue Zhang, Leszek Lisowski, Kalpana Ghoshal
Publikováno v:
Molecular Therapy. 24:S290-S291
To ensure success of RNA interference (RNAi) therapeutics, small hairpin RNAs (shRNAs) must co-opt sufficient quantities of the endogenous microRNA machinery to elicit efficient gene knockdown without impeding normal cellular function or causing live
Publikováno v:
Molecular Therapy. 24:S116