Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kevin J Harrington"'
Autor:
Matthew C. Coffey, Richard G. Vile, Timothy Kottke, Hardev Pandha, Alan Melcher, Jill Thompson, Kevin J. Harrington, Shane Zaidi, Kevin G. Shim, Christopher Parrish, Liz Ilett, Rosa Maria Diaz, Karishma Rajani
Publikováno v:
Molecular Therapy. 24:166-174
Oncolytic reovirus can be delivered both systemically and intratumorally, in both preclinical models and in early phase clinical trials. Reovirus has direct oncolytic activity against a variety of tumor types and antitumor activity is directly associ
Autor:
Miran Blanchard, Kevin G. Shim, Peter Selby, Esteban Celis, Hardev Pandha, Tim Kottke, Richard G. Vile, Alan Melcher, Elizabeth Ilett, Karishma Rajani, Jill Thompson, Nicolas Boisgerault, Kevin J. Harrington, Shane Zaidi, Jose S. Pulido, Christopher Parrish
Publikováno v:
Molecular Therapy. 23(5):845-856
We used a VSV-cDNA library to treat recurrent melanoma, identifying immunogenic antigens, allowing us to target recurrences with immunotherapy or chemotherapy. Primary B16 melanoma tumors were induced to regress by frontline therapy. Mice with recurr
Autor:
Diana Rommelfanger-Konkol, Peter Selby, Timothy Kottke, Elizabeth Ilett, Kevin J. Harrington, Karishma Rajani, Shane Zaidi, Hardev Pandha, Jose S. Pulido, O Donnelly, Alan Melcher, Richard G. Vile, Rosa Maria Diaz, Vanesa Alonso-Camino, Jill Thompson
Publikováno v:
Molecular Therapy. 22(11):1936-1948
Previously, we showed that vesicular stomatitis virus (VSV) engineered to express a cDNA library from human melanoma cells (ASMEL, Altered Self Melanoma Epitope Library) was an effective systemic therapy to treat subcutaneous (s.c.) murine B16 melano
Autor:
Alan Melcher, Oliver Donnelly, Jill Thompson, Hardev Pandha, Candice Willmon, Matthew C. Coffey, Kevin J. Harrington, Shane Zaidi, Rosa Maria Diaz, Peter Selby, Timothy Kottke, Richard G. Vile, Elizabeth Ilett
Publikováno v:
Molecular Therapy. 22(10):1851-1863
Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor
Autor:
Alan Melcher, Feorillo Galivo, Jill Thompson, Kevin J. Harrington, Steven M. Albelda, Rosa Maria Diaz, Timothy Kottke, Phonphimon Wongthida, Candice Willmon, Richard G. Vile
Publikováno v:
Molecular Therapy. 19(1):140-149
Despite having potent oncolytic activity, in vitro, direct intratumoral injection of oncolytic vesicular stomatitis virus (VSV) into established AE17ova mesothelioma tumors in C57Bl/6 mice had no therapeutic effect. During studies to combine systemic
Autor:
Timothy Kottke, Robin Prestwich, Alan Melcher, Kevin J. Harrington, Richard G. Vile, Candice Willmon
Publikováno v:
Molecular Therapy. 17:1667-1676
Oncolytic viruses delivered directly into the circulation face many hazards that impede their localization to, and infection of, metastatic tumors. Such barriers to systemic delivery could be overcome if couriers, which confer both protection, and tu