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Autor:
Terri Gelbart, D L Graham, G E Sandusky, Anantha Shekhar, J O Niezer, Daniel R. Salomon, A. Williams, Sunil M. Kurian, H L Dainton, A Ballew, Helen Le-Niculescu, T. Jones, E M Niculescu, K. Roseberry, V Venugopal, Daniel F. Levey, Nicholas J. Schork, M Yard, Alexander B. Niculescu, Peter Phalen
Publikováno v:
Molecular Psychiatry
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identific
Autor:
Tanja Jovanovic, Brian G. Dias, Vasiliki Michopoulos, Elisabeth B. Binder, Negar Fani, Seth D. Norrholm, Kerry J. Ressler, Jaemin Shin, Lynn M. Almli, Alicia K. Smith, Ziyu Ding, Stephanie A. Maddox, Karen N. Conneely, Varun Kilaru
Publikováno v:
Molecular Psychiatry
MOLECULAR PSYCHIATRY
MOLECULAR PSYCHIATRY
Women are at increased risk of developing post-traumatic stress disorder (PTSD) following a traumatic event. Recent studies suggest that this may be mediated, in part, by circulating estrogen levels. This study evaluated the hypothesis that individua
Autor:
Yuri Milaneschi, Rick Jansen, Abbas Dehghan, Gonneke Willemsen, Wouter J. Peyrot, Jouke-Jan Hottenga, Hamdi Mbarek, Abdel Abdellaoui, Chen Lu, Dorret I. Boomsma, Femke Lamers, B.W.J.H. Penninx
Publikováno v:
Milaneschi, Y, Lamers, F, Peyrot, W J, Abdellaoui, A, Willemsen, G, Hottenga, J-J, Jansen, R, Mbarek, H, Dehghan, A, Lu, C, Boomsma, D I & Penninx, B W J H 2016, ' Polygenic dissection of major depression clinical heterogeneity ', Molecular Psychiatry, vol. 21, no. 4, pp. 516-522 . https://doi.org/10.1038/mp.2015.86
Molecular Psychiatry, 21(4), 516-522. Nature Publishing Group
Milaneschi, Y, Winkelman, F, Peyrot, W, Abdellaoui, A, Willemsen, G, Hottenga, J J, Jansen, R, Mbarek, H, Dehghan, A, Lu, C, Boomsma, D I & Penninx, B W J H 2016, ' Polygenic dissection of major depression clinical heterogeneity ', Molecular Psychiatry, vol. 21, no. 4, pp. 516-522 . https://doi.org/10.1038/mp.2015.86
Molecular Psychiatry, 21(4), 516-522. Nature Publishing Group
Milaneschi, Y, Winkelman, F, Peyrot, W, Abdellaoui, A, Willemsen, G, Hottenga, J J, Jansen, R, Mbarek, H, Dehghan, A, Lu, C, Boomsma, D I & Penninx, B W J H 2016, ' Polygenic dissection of major depression clinical heterogeneity ', Molecular Psychiatry, vol. 21, no. 4, pp. 516-522 . https://doi.org/10.1038/mp.2015.86
The molecular mechanisms underlying major depressive disorder (MDD) are largely unknown. Limited success of previous genetics studies may be attributable to heterogeneity of MDD, aggregating biologically different subtypes. We examined the polygenic
Autor:
Park Ws, Alan F. Schatzberg, Lee Ms, Insop Shim, Rhim H, David M. Lyons, Dona L. Wong, Song Her, Seung Hae Kwon, Kim Yh, Park Ok, Hong Ks, Morita K, Paresh D. Patel
Publikováno v:
Molecular Psychiatry
Previous studies have shown inconsistent results regarding the actions of antidepressants on glucocorticoid receptor (GR) signalling. To resolve these inconsistencies, we used a lentiviral-based reporter system to directly monitor rat hippocampal GR