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Autor:
Melissa Sorosina, Ferdinando Clarelli, P. Provero, G. Comi, F. Martinelli Boneschi, Laura Ferrè, Federica Esposito, Massimo Filippi, Elisabetta Mascia, Linda Ottoboni, Giacomo Sferruzza, Silvia Santoro, Lucia Moiola, Vittorio Martinelli
Publikováno v:
Molecular Neurobiology. 58:4816-4827
Fingolimod (FTY), a second-line oral drug approved for relapsing remitting Multiple Sclerosis (RRMS) acts in preventing lymphocyte migration outside lymph nodes; moreover, several lines of evidence suggest that it also inhibits myeloid cell activatio
Publikováno v:
Molecular Neurobiology. 58:4628-4638
Drug addiction is a global health problem and continues to place an enormous financial burden on society. This addiction is characterized by drug dependence sensitization and craving. Morphine has been widely used for pain relief, but chronic adminis
Autor:
Mohammad Taghi Joghataei, Abolfazl Azami Tameh, Zeinab Vahidinia, Mohammad Karimian, Cordian Beyer
Publikováno v:
Molecular Neurobiology. 58:4588-4614
In ischemic stroke, there is only one approved drug, tissue plasminogen activator, to be used in clinical conditions for thrombolysis. New neuroprotective therapies for ischemic stroke are desperately needed. Several targets and pathways have been sh
Autor:
Alireza Zali, Fatemeh Rostami, Maryam Oraee-Yazdani, Ehsan Arefian, Masoud Soleimani, Saeed Oraee-Yazdani, Gelareh Shokri, Mohammadhosein Akhlaghpasand, Mina Soufi Zomorrod, Fatemeh Jamshidi-Adegani, Maryam Hafizi, Maryam Golmohammadi
Publikováno v:
Molecular Neurobiology. 58:4425-4436
Widespread investigation has revealed the promising ability of suicidal genes in the treatment of glioma tumors; nevertheless, promoting their effects relies on the ability to apply suitable vehicles and techniques. In this study, the safety and feas
Autor:
Artur Łazorczyk, Agnieszka Michalak, Sylwia Talarek, Paulina Kozioł, Olga Wronikowska, Maria Zykubek, Radosław Pietura, Katarzyna Kochalska, Barbara Budzyńska, Łukasz Kurach, Tymoteusz Słowik, Joanna Kurzepa, Anna Pankowska, Anna Boguszewska-Czubara
Publikováno v:
Molecular Neurobiology
Mephedrone is a widely used drug of abuse, exerting its effects by interacting with monoamine transporters. Although this mechanism has been widely studied heretofore, little is known about the involvement of glutamatergic transmission in mephedrone
Publikováno v:
Molecular Neurobiology. 58:4251-4267
Neuroinflammation can cause cognitive deficits, and preexisting neuroinflammation is observed frequently in the clinic after trauma, surgery, and infection. Patients with preexisting neuroinflammation often need further medical treatment under genera
Autor:
Xiaoming Huang, Xiaoshuai Ji, Rui Zhang, Dan Wang, Jun Sun, Qian Liu, Jingxia Tian, Zixiao Wang, Jiajia Gao, Dong He, Yanbang Wei, Qi Pang
Publikováno v:
Molecular Neurobiology. 58:3918-3937
In neonatal hypoxic-ischemic brain damage (HIBD), in addition to damage caused by hypoxia and ischemia, over-activation of inflammation leads to further deterioration of the condition, thus greatly shortening the optimal treatment time window. Ischem
Autor:
Mohammed Al-Hawwas, Xin-Fu Zhou, Fiona H. Zhou, Jing Xiong, Isaac Deng, Larisa Bobrovskaya, Liying Lin, Sally Kelliny
Publikováno v:
Molecular Neurobiology. 58:3692-3711
Alzheimer’s disease (AD) is the most common cause of dementia among elderly people. Majority of AD cases are sporadic (SAD) with unknown cause. Transgenic animal models closely reflect the familial (genetic) aspect of the disease but not the sporad
Autor:
Ruth E. Rosenstein, Marcos L. Aranda, María Florencia González Fleitas, Pablo H. Sande, Agustina Iaquinandi, Julián Daniel Devouassoux, Hernán H. Dieguez, Juan Salvador Calanni, Damián Dorfman
Publikováno v:
Molecular Neurobiology. 58:3653-3664
Glaucoma is a blindness-causing disease that involves selective damage to retinal ganglion cells (RGCs) and their axons. A subset of RGCs expressing the photopigment melanopsin regulates non-image-forming visual system functions, such as pupillary li
Autor:
Panayotis K. Thanos, David Baron, B. William Downs, Kenneth Blum, Mark S. Gold, Rajendra D. Badgaiyan, Philip Fynman, Edward J Modestino, Raymond Brewer, Jean Lud Cadet, Marjorie C Gondré–Lewis., Sampada Badgaiyan, Igor Elman, David E. Smith, Jessica Valdez Ponce, Mark Moran, Alexander Weingarten, Lisa Lott
Publikováno v:
Molecular Neurobiology
Millions of Americans experience pain daily. In 2017, opioid overdose claimed 64,000 lives increasing to 84,000 lives in 2020, resulting in a decrease in national life expectancy. Chronic opioid use results in dependency, drug tolerance, neuroadaptat