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Publikováno v:
Molecular Neurobiology. 58:4628-4638
Drug addiction is a global health problem and continues to place an enormous financial burden on society. This addiction is characterized by drug dependence sensitization and craving. Morphine has been widely used for pain relief, but chronic adminis
Autor:
Artur Łazorczyk, Agnieszka Michalak, Sylwia Talarek, Paulina Kozioł, Olga Wronikowska, Maria Zykubek, Radosław Pietura, Katarzyna Kochalska, Barbara Budzyńska, Łukasz Kurach, Tymoteusz Słowik, Joanna Kurzepa, Anna Pankowska, Anna Boguszewska-Czubara
Publikováno v:
Molecular Neurobiology
Mephedrone is a widely used drug of abuse, exerting its effects by interacting with monoamine transporters. Although this mechanism has been widely studied heretofore, little is known about the involvement of glutamatergic transmission in mephedrone
Publikováno v:
Molecular Neurobiology. 58:4251-4267
Neuroinflammation can cause cognitive deficits, and preexisting neuroinflammation is observed frequently in the clinic after trauma, surgery, and infection. Patients with preexisting neuroinflammation often need further medical treatment under genera
Autor:
Yansong Li, Hui Gao, Wei Yuan, Shuang Li, Na Li, Haiqing Chang, Yuxin Zhang, Bo Cheng, Qiang Wang
Publikováno v:
Molecular Neurobiology. 58:3061-3070
Among all the side effects, opioid-induced constipation (OIC) has the highest incidence rate in people who take chronic opioid therapy. Increasing evidence shows that enteric glial cells (EGCs) play a pivotal role in the modulation of gastrointestina
Publikováno v:
Molecular Neurobiology
Chronic adenosine A1R stimulation in hypoxia leads to persistent hippocampal synaptic depression, while unopposed adenosine A2AR receptor stimulation during hypoxia/reperfusion triggers adenosine-induced post-hypoxia synaptic potentiation (APSP) and
Autor:
Ola A. Heikal, May A. Abd El Fattah, Mohammed F. El-Yamany, Yasmine A. Abdelhamid, Osama A. Badary
Publikováno v:
Molecular Neurobiology. 58:1504-1516
PPAR-γ anti-inflammatory functions have received significant attention since its agonists have been shown to exert a wide range of protective effects in many experimental models of neurologic diseases. Rice bran is very rich in polyunsaturated fatty
Publikováno v:
Molecular Neurobiology
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)—as seen by effects on smell, taste, seizures, stroke, ne
Publikováno v:
Molecular Neurobiology. 57:4187-4201
Amyloid-β (Aβ) peptides play a significant role in the pathogenesis of Alzheimer’s disease (AD). Neurotoxic effects promoted by Aβ peptides involve glutamate transmission impairment, decrease of neurotrophic factors, mitochondrial dysfunction, o
Autor:
Kuang-I Cheng, Hung-Chen Wang, Yi-Hsuan Wang, Miao-Pei Su, Yi-Ta Chuang, Lin-Li Chang, Jaw-Yuan Wang, Kuang-Yi Tseng
Publikováno v:
Molecular Neurobiology. 57:3931-3942
The micro (mi)RNAs expressed in the sciatic nerve of streptozotocin (STZ)-induced diabetic rats were evaluated in terms of their therapeutic potential in patients with diabetic neuropathic pain (DNP). Relative miRNA expression in sciatic nerve with D
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Conventional antidepressant drugs elevate the availability of monoamine neurotransmitters. However, these pharmacological therapies have limited efficacy and a slow onset of action as main limitations. New glutamatergic drugs such as ketamine have sh