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Autor:
Andreza Fabro de Bem, Antonio L. Braga, Flavio A. R. Barbosa, Ruth Liliám Quispe, Michael L. Jaramillo, Rômulo Faria Santos Canto, Marcelo Farina
Publikováno v:
Molecular Neurobiology. 55:7619-7634
Recent studies have shown that probucol (PB), a hipocholesterolemic agent with antioxidant and anti-inflammatory properties, presents neuroprotective properties. On the other hand, adverse effects have limited PB's clinical application. Thus, the sea
Publikováno v:
Molecular Neurobiology. 55:7579-7587
Nuclear receptor related 1 (Nurr1) orphan receptor has emerged as a promising contender in ameliorating Parkinson's disease; thus, finding a suitable activator of Nurr1 receptor is an attracting target for treating PD. Cilostazol, a phosphodiesterase
Autor:
Karthika Nellaiappan, Anil Kumar Kalvala, Ashutosh Kumar, Aparna Areti, Prashanth Komirishetty
Publikováno v:
Molecular Neurobiology. 55:7463-7475
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting complication which develops as a consequence of treatment with chemotherapeutic agents like oxaliplatin and is a mainstay of therapy for colorectal cancer. Ever since CIPN was ident
Publikováno v:
Molecular Neurobiology. 55:6572-6588
All current treatments of Parkinson's disease (PD) focus on enhancing the dopaminergic effects and providing symptomatic relief; however, they cannot delay the disease progression. Filgrastim, a recombinant methionyl granulocyte colony-stimulating fa
Publikováno v:
Molecular Neurobiology. 55:5727-5740
Chemobrain refers to a common sequelae experienced by 15-80% of cancer patients exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been implicated in a strenuous neurotoxicity manifested as decline in cognitive functions, mo
Autor:
Young-Kyoung Ryu, Hye-Yeon Park, Tae Geol Lee, Jung Hwan Hwang, Yong-Hoon Kim, Kyoung-Shim Kim, Chul-Ho Lee, Jung-Ran Noh, Dong-Hee Choi, Jun Go
Publikováno v:
Molecular Neurobiology. 55:5715-5726
Metformin is a medication that is widely prescribed for the management of type 2 diabetes. In addition to its anti-diabetic uses, metformin has been proposed as a therapeutically effective drug candidate in various central nervous system disorders, i
Autor:
Z. Ryan Tian, José Vicente Lafuente, Asya Ozkizilcik, Hari Shanker Sharma, Aruna Sharma, Ranjana Patnaik, Dafin F. Muresanu
Publikováno v:
Molecular Neurobiology. 55:322-334
The possibility that stress associated with chronic forced swim (FS) may exacerbate methamphetamine (METH) neurotoxicity was examined in a rat model. Rats were subjected to FS in a pool (30 °C) for 15 min daily for 8 days. Control rats were kept at
Autor:
Alessandra Ottani, Paola Orlandi, Guido Bocci, Daniela Giuliani, Francesca Vaglini, C Pardini, Francesco Pasqualetti, Teresa Di Desidero, Simone Pacini, Salvatore Guarini
Publikováno v:
Molecular Neurobiology. 55:4984-4997
Currently, no description of melanocortin receptor-4 (MC4R) expression or activity is available in human cancer cells, including glioblastoma (GBM). The aim of this study is to evaluate the presence of MC4Rs in GBM cells and the selective inhibition
Autor:
Anna Boguszewska-Czubara, Marta Kruk-Slomka, Barbara Budzyńska, Karolina Pekala, K. Grot, Agnieszka Michalak, Grazyna Biala
Publikováno v:
Molecular Neurobiology
Addiction is a chronic psychiatric disease which represents a global problem, and stress can increase drug addiction and relapse. Taking into account frequent concomitance of nicotine dependence and stress, the purpose of the present study was to ass
Autor:
Arman Ai, Mostafa Soleimannejad, Jafar Ai, Hooshang Saberi, Somayeh Ebrahimi-Barough, Abbas Norouzi-Javidan, Mohammad Mehdi Mokhtari Ardakan, Neda Bayat
Publikováno v:
Molecular Neurobiology. 55:2102-2110
Glioblastoma multiform (GBM) is a primary malignant brain tumor with a few therapeutic targets available for it. The interaction between the immune system and glioma is an important factor that could lead to novel therapeutic approaches to fight glio