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Autor:
Maria José Alves da Rocha, Carlos Henrique Rocha Catalão, Luís Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior
Publikováno v:
Molecular Neurobiology. 58:2133-2144
Sepsis promotes an inflammatory state in the central nervous system (CNS) that may cause autonomic, cognitive, and endocrine changes. Microglia, a resident immune cell of the CNS, is activated in several brain regions during sepsis, suggesting its pa
Autor:
Oliver Wirths, Martina Stazi
Publikováno v:
Molecular Neurobiology
Memantine, a non-competitive NMDA receptor antagonist possessing neuroprotective properties, belongs to the small group of drugs which have been approved for the treatment of Alzheimer’s disease (AD). While several preclinical studies employing dif
Publikováno v:
Molecular Neurobiology. 57:5044-5055
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that leads to progressive cognitive, memory, and learning dysfunction that affects the aging population. Dexmedetomidine (Dex) might be beneficial for postoperative cognitive func
Autor:
Deodutta Roy, Kaumudi Bhawe, Varindera P Singh, Ishani Mohapatra, Quentin Felty, Changwon Yoo, Nasreen Z. Ehtesham, Seyed Ehtesham Hasnain
Publikováno v:
Molecular Neurobiology. 57:3827-3845
Despite tremendous progress in understanding the pathobiology of astrocytoma, major gaps remain in our knowledge of the molecular basis underlying the aggressiveness of high-grade astrocytoma (glioblastoma - GBM). Recently, we and others have shown n
Autor:
Carmela Giampà, Claudia Balducci, Vincenza D'Angelo, Luisa Artioli, Vladimiro Artuso, Emanuela Paldino, Pietro La Vitola, Gianluigi Forloni, Francesca Fusco
Publikováno v:
Molecular Neurobiology
Mechanisms of tissue damage in Huntington’s disease involve excitotoxicity, mitochondrial damage, and inflammation, including microglia activation. Immunomodulatory and anti-protein aggregation properties of tetracyclines were demonstrated in sever
Autor:
Juan M. Saavedra, Abdel G. Elkahloun
Publikováno v:
Mol Neurobiol
Preclinical experiments and clinical trials demonstrated that angiotensin II AT1 receptor overactivity associates with aging and cellular senescence and that AT1 receptor blockers (ARBs) protect from age-related brain disorders. In a primary neuronal
Autor:
Annalucia Carbone, Mario Bossi, C. Grasselli, Gianluigi Mazzoccoli, L. De Filippis, Vincenzo Giambra, Patrizio Panelli
Publikováno v:
Molecular Neurobiology. 57:1502-1515
Autism spectrum disorders (ASD) comprise a complex of neurodevelopmental disorders caused by a variety of genetic defects and characterized by alterations in social communication and repetitive behavior. Since the mechanisms leading to early neuronal
Publikováno v:
Mol Neurobiol
Mitochondrial dysfunction and oxidative stress play a key role in ischemia/reperfusion (I/R) induced brain injury. We previously showed that ubiquilin-1 (Ubqln1), a ubiquitin-like protein, improves proteostasis and protects brains against oxidative s
Autor:
Vivian Dambeck, Dirk Balke, Paul Lingor, Uwe Michel, Vinicius Toledo Ribas, Lars Tatenhorst, Björn Friedhelm Vahsen, Mathias Bähr
Publikováno v:
Molecular Neurobiology. 57:685-697
Loss of nigrostriatal projections by axonal degeneration is a key early event in Parkinson's disease (PD) pathophysiology, being accountable for the lack of dopamine in the nigrostriatal system and resulting in motor symptoms such as bradykinesia, ri
Publikováno v:
Molecular Neurobiology. 56:7741-7753
The innate immune system and inflammatory response in the brain have critical impacts on the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD). In the central nervous system (CNS), the innate immune response is primar