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Autor:
Artur Łazorczyk, Agnieszka Michalak, Sylwia Talarek, Paulina Kozioł, Olga Wronikowska, Maria Zykubek, Radosław Pietura, Katarzyna Kochalska, Barbara Budzyńska, Łukasz Kurach, Tymoteusz Słowik, Joanna Kurzepa, Anna Pankowska, Anna Boguszewska-Czubara
Publikováno v:
Molecular Neurobiology
Mephedrone is a widely used drug of abuse, exerting its effects by interacting with monoamine transporters. Although this mechanism has been widely studied heretofore, little is known about the involvement of glutamatergic transmission in mephedrone
Autor:
Oliver Wirths, Martina Stazi
Publikováno v:
Molecular Neurobiology
Memantine, a non-competitive NMDA receptor antagonist possessing neuroprotective properties, belongs to the small group of drugs which have been approved for the treatment of Alzheimer’s disease (AD). While several preclinical studies employing dif
Autor:
Carmela Giampà, Claudia Balducci, Vincenza D'Angelo, Luisa Artioli, Vladimiro Artuso, Emanuela Paldino, Pietro La Vitola, Gianluigi Forloni, Francesca Fusco
Publikováno v:
Molecular Neurobiology
Mechanisms of tissue damage in Huntington’s disease involve excitotoxicity, mitochondrial damage, and inflammation, including microglia activation. Immunomodulatory and anti-protein aggregation properties of tetracyclines were demonstrated in sever
Autor:
Vivian Dambeck, Dirk Balke, Paul Lingor, Uwe Michel, Vinicius Toledo Ribas, Lars Tatenhorst, Björn Friedhelm Vahsen, Mathias Bähr
Publikováno v:
Molecular Neurobiology. 57:685-697
Loss of nigrostriatal projections by axonal degeneration is a key early event in Parkinson's disease (PD) pathophysiology, being accountable for the lack of dopamine in the nigrostriatal system and resulting in motor symptoms such as bradykinesia, ri
Autor:
Marissa Giovanna Schamne, Aderbal S. Aguiar, Rui Daniel Prediger, Ana Elisa Speck, Rodrigo A. Cunha
Publikováno v:
Molecular Neurobiology. 56:2944-2951
Exercise can act as a disease-modifying agent in Parkinson's disease (PD), and we have previously demonstrated that voluntary exercise in running wheels during 2 weeks normalizes striatopallidal dopaminergic signaling and prevents the development of
Autor:
Daniel Garrigos, Bruno Ribeiro Do-Couto, Angel Toval, Nicanor Morales-Delgado, José Luis Ferran, Kuei Y. Tseng, Yevheniy Kutsenko, Miroljub Popović
Publikováno v:
Molecular Neurobiology
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge coul
Publikováno v:
Molecular neurobiology. 58(4)
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterised by the selective loss of motor neurons, muscular atrophy, and degeneration. Statins, as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are the most widely p
Publikováno v:
Molecular neurobiology. 58(5)
Energy-dense foods and ethanol consumption are associated with mood disorders. m-Trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] has been a prominent pharmacological target due to its antidepressant-like effects. This study investigated if the mo
Autor:
Sheng Song, Belinda Wilson, Zibo Li, Yen-Yu Ian Shih, Esteban A. Oyarzabal, Qingshan Wang, Jau-Shyong Hong, Lulu Jiang
Publikováno v:
Molecular Neurobiology. 56:2653-2669
Environmental toxicant exposure has been strongly implicated in the pathogenesis of Parkinson's disease (PD). Clinical manifestations of non-motor and motor symptoms in PD stem from decades of progressive neurodegeneration selectively afflicting disc
Autor:
Millan Mark, Kevin C. F. Fone, Rodolphe Billiras, Alain P. Gobert, Anne Dekeyne, Jean-Michel Rivet, Dorothée Sicard, David J. G. Watson
Publikováno v:
Molecular Neurobiology
Frontocortical NMDA receptors are pivotal in regulating cognition and mood, are hypofunctional in schizophrenia, and may contribute to autistic spectrum disorders. Despite extensive interest in agents potentiating activity at the co-agonist glycine m