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Autor:
Vivian Dambeck, Dirk Balke, Paul Lingor, Uwe Michel, Vinicius Toledo Ribas, Lars Tatenhorst, Björn Friedhelm Vahsen, Mathias Bähr
Publikováno v:
Molecular Neurobiology. 57:685-697
Loss of nigrostriatal projections by axonal degeneration is a key early event in Parkinson's disease (PD) pathophysiology, being accountable for the lack of dopamine in the nigrostriatal system and resulting in motor symptoms such as bradykinesia, ri
Autor:
Sunil Bhurtel, Sina Shadfar, Yu-Gyeong Kim, Nikita Katila, Sunil Srivastav, Jin Tae Hong, Uttam Ojha, Gil-Saeng Jeong, Pil-Hoon Park, Sabita Neupane, Dong-Young Choi
Publikováno v:
Molecular Neurobiology. 55:554-566
Neurotrophic factors are essential for neuronal survival, plasticity, and development and have been implicated in the action mechanism of antidepressants. In this study, we assessed the neurotrophic factor-inducing and neuroprotective properties of a
Publikováno v:
Molecular Neurobiology. 54:5632-5645
Parkinson's disease (PD) having a complex and multi-factorial neuropathology includes mainly the degeneration of the dopaminergic nigrostriatal pathway, which is a cumulative effect of depleted endogenous antioxidant enzymes, increased oxidative DNA
Publikováno v:
Molecular Neurobiology. 54:4292-4302
Caspase family has been recognized to be involved in dopaminergic (DA) neuronal death and to exert an unfavorable role in Parkinson's disease (PD) pathology. Our previous study has revealed that caspase-1, as an important component of NLRP3 inflammas
Publikováno v:
Molecular Neurobiology. 54:3618-3632
A crucial event in the pathogenesis of Parkinson's disease is the death of dopaminergic neurons of the nigrostriatal system, which are responsible for the regulation of motor function. Motor symptoms first appear in patients 20-30 years after the ons
Autor:
Herbert Mössler, Ranjana Patnaik, Z. Ryan Tian, Asya Ozkizilcik, Dafin F. Muresanu, Hari Shanker Sharma, José Vicente Lafuente, Aruna Sharma
Publikováno v:
Molecular neurobiology. 55(1)
Previous studies from our laboratory show that intraperitoneal injections of 1-metyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP, 20 mg/kg) daily within 2-h intervals for 5 days in mice induce Parkinson’s disease (PD)-like symptoms on the 8th day. A s