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Publikováno v:
Molecular Neurobiology
The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS)—as seen by effects on smell, taste, seizures, stroke, ne
Autor:
Carmela Giampà, Claudia Balducci, Vincenza D'Angelo, Luisa Artioli, Vladimiro Artuso, Emanuela Paldino, Pietro La Vitola, Gianluigi Forloni, Francesca Fusco
Publikováno v:
Molecular Neurobiology
Mechanisms of tissue damage in Huntington’s disease involve excitotoxicity, mitochondrial damage, and inflammation, including microglia activation. Immunomodulatory and anti-protein aggregation properties of tetracyclines were demonstrated in sever
Autor:
José L. M. Madrigal, Juan C. Leza, Marta González-Prieto, Irene L Gutiérrez, Javier R. Caso, Borja García-Bueno
Publikováno v:
Molecular Neurobiology. 56:8628-8642
The reduction of brain noradrenaline levels is associated to the initiation of Alzheimer's disease and contributes to its progression. This seems to be due mainly to the anti-neuroinflammatory actions of noradrenaline. The analysis of noradrenaline e
Autor:
Euler Esteves Ribeiro, Kennya Mota, Alencar Kolinski Machado, Diulie Valente de Souza, Francine Carla Cadoná, David Frederick Bodenstein, Tuyla Fontana, Carolina Bordin Davidson, Michele Rorato Sagrillo, Andiara Prates Ramos, Ana Cristina Andreazza, Mirian Salvador
Publikováno v:
Molecular neurobiology. 58(9)
Neurological disorders have been demonstrated to be associated with mitochondrial dysfunction. This impairment may lead to oxidative stress and neuroinflammation, specifically promoted by NLRP3 expression. Acai (Euterpe oleracea Mart.) has been studi
Autor:
Minglei Guo, Ashutosh Tripathi, Annadurai Thangaraj, Ernest T. Chivero, Shilpa Buch, Palsamy Periyasamy
Publikováno v:
Mol Neurobiol
Cocaine use disorder is a major health crisis that is associated with increased oxidative stress and neuroinflammation. While the role of NLRP3 inflammasome in mediating neuroinflammation is well-recognized, whether cocaine induces this response rema
Autor:
Piotr Listos, Małgorzata Łupina, Jolanta Kotlinska, Izabela Gutowska, Joanna Listos, Sylwia Talarek, Maciej Tarnowski, Irena Baranowska-Bosiacka
Publikováno v:
Molecular Neurobiology
The present study focused upon the role of SB-334867, an orexin-1 receptor antagonist, in the acquisition of morphine-induced sensitization to locomotor activity in mice. Behavioral sensitization is an enhanced systemic reaction to the same dose of a
Autor:
Shih Heng Chen, Mingri Guo, Shuo Li, Yueh Feng Sung, Chun Hsien Chu, Jau-Shyong Hong, Jeremy A. Leonard, Esteban A. Oyarzabal, Qingshan Wang, Ru Band Lu, Shiou Lan Chen, Yu Mei Tan
Publikováno v:
Molecular Neurobiology. 55:8001-8013
This study investigated the physiological regulation of brain immune homeostasis in rat primary neuron-glial cultures by sub-nanomolar concentrations of prostaglandin E2 (PGE(2)). We demonstrated that 0.01 to 10 nM PGE(2) protected dopaminergic neuro
Publikováno v:
Molecular Neurobiology. 55:6572-6588
All current treatments of Parkinson's disease (PD) focus on enhancing the dopaminergic effects and providing symptomatic relief; however, they cannot delay the disease progression. Filgrastim, a recombinant methionyl granulocyte colony-stimulating fa
Autor:
Shijun Zhang, Jacob Fulp, Xiongwei Zhu, Jeremy E. Chojnacki, Jun Yin, Fanpeng Zhao, William L. Klein
Publikováno v:
Molecular Neurobiology. 55:1977-1987
The activation of the NLRP3 inflammasome signaling pathway plays an important role in the neuroinflammation in Alzheimer’s disease (AD). In this study, we investigated the effects of JC-124, a rationally designed NLRP3 inflammasome inhibitor, on AD
Autor:
Andiara E. Freitas, Vanessa Gómez-Rangel, Antonio Cuadrado, Javier Egea, Izaskun Buendia, Elisa Navarro, José Avendaño Ortiz, Manuela G. López, Ana Ruiz-Nuño, Aneta Wojnicz, Ana I. Casas, Esther Parada, Ana Lúcia S. Rodrigues
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Neurobiology, 53(5), 3030-3045. Springer, Cham
instname
Molecular Neurobiology, 53(5), 3030-3045. Springer, Cham
Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression. A recent study by our group demonstrated that agmatine induces Nrf2 and protects against corticosterone effects i