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Autor:
Melissa Sorosina, Ferdinando Clarelli, P. Provero, G. Comi, F. Martinelli Boneschi, Laura Ferrè, Federica Esposito, Massimo Filippi, Elisabetta Mascia, Linda Ottoboni, Giacomo Sferruzza, Silvia Santoro, Lucia Moiola, Vittorio Martinelli
Publikováno v:
Molecular Neurobiology. 58:4816-4827
Fingolimod (FTY), a second-line oral drug approved for relapsing remitting Multiple Sclerosis (RRMS) acts in preventing lymphocyte migration outside lymph nodes; moreover, several lines of evidence suggest that it also inhibits myeloid cell activatio
Publikováno v:
Molecular Neurobiology. 58:4628-4638
Drug addiction is a global health problem and continues to place an enormous financial burden on society. This addiction is characterized by drug dependence sensitization and craving. Morphine has been widely used for pain relief, but chronic adminis
Autor:
Alireza Zali, Fatemeh Rostami, Maryam Oraee-Yazdani, Ehsan Arefian, Masoud Soleimani, Saeed Oraee-Yazdani, Gelareh Shokri, Mohammadhosein Akhlaghpasand, Mina Soufi Zomorrod, Fatemeh Jamshidi-Adegani, Maryam Hafizi, Maryam Golmohammadi
Publikováno v:
Molecular Neurobiology. 58:4425-4436
Widespread investigation has revealed the promising ability of suicidal genes in the treatment of glioma tumors; nevertheless, promoting their effects relies on the ability to apply suitable vehicles and techniques. In this study, the safety and feas
Autor:
Xiaoming Huang, Xiaoshuai Ji, Rui Zhang, Dan Wang, Jun Sun, Qian Liu, Jingxia Tian, Zixiao Wang, Jiajia Gao, Dong He, Yanbang Wei, Qi Pang
Publikováno v:
Molecular Neurobiology. 58:3918-3937
In neonatal hypoxic-ischemic brain damage (HIBD), in addition to damage caused by hypoxia and ischemia, over-activation of inflammation leads to further deterioration of the condition, thus greatly shortening the optimal treatment time window. Ischem
Autor:
Ruth E. Rosenstein, Marcos L. Aranda, María Florencia González Fleitas, Pablo H. Sande, Agustina Iaquinandi, Julián Daniel Devouassoux, Hernán H. Dieguez, Juan Salvador Calanni, Damián Dorfman
Publikováno v:
Molecular Neurobiology. 58:3653-3664
Glaucoma is a blindness-causing disease that involves selective damage to retinal ganglion cells (RGCs) and their axons. A subset of RGCs expressing the photopigment melanopsin regulates non-image-forming visual system functions, such as pupillary li
Autor:
João Lopes, Rodrigo A. Cunha, Paula M. Canas, Ângelo R. Tomé, Henrique B. Silva, Ana Moreira-de-Sá, Francisco Q. Gonçalves
Publikováno v:
Molecular Neurobiology. 58:2543-2557
Angelman syndrome (AS) is a neurogenetic disorder involving ataxia and motor dysfunction, resulting from the absence of the maternally inherited functional Ube3a protein in neurons. Since adenosine A2A receptor (A2AR) blockade relieves synaptic and m
Autor:
Maria José Alves da Rocha, Carlos Henrique Rocha Catalão, Luís Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior
Publikováno v:
Molecular Neurobiology. 58:2133-2144
Sepsis promotes an inflammatory state in the central nervous system (CNS) that may cause autonomic, cognitive, and endocrine changes. Microglia, a resident immune cell of the CNS, is activated in several brain regions during sepsis, suggesting its pa
Autor:
Jucilene Freitas-Santos, Amanda Larissa Dias Pacheco, Ana Catarina Rezende Leite, Igor Santana de Melo, Reginaldo Correia Silva-Filho, Daniel Góes Leite Gitaí, Yngrid Mickaelli Oliveira dos Santos, Maisa de Araújo Costa, Robinson Sabino-Silva, Vanessa de Oliveira Silva, Alexandre Urban Borbely, Marcelo Duzzioni, Cibelle de Melo Bastos Cavalcante, Olagide W. Castro
Publikováno v:
Molecular Neurobiology. 58:1217-1236
Status epilepticus (SE) is defined as continuous and self-sustaining seizures, which trigger hippocampal neurodegeneration, mitochondrial dysfunction, oxidative stress, and energy failure. During SE, the neurons become overexcited, increasing energy
Autor:
Chang-Bin Yang, Yan-Yan Jia, Min Wang, Yu-Mei Wu, An Liu, Chen Qiu, Wen Yu, Mei-Rong Gao, Kun Zhang, Le Yang, Wen-Ju Wang, Dan-Dan Tian
Publikováno v:
Molecular Neurobiology. 58:761-776
Nod-like receptor protein 3 (NLRP3)-associated neuroinflammation mediated by activated microglia is involved in the pathogenesis of depression. The role of the pore-forming protein gasdermin D (GSDMD), a newly identified pyroptosis executioner downst
Autor:
Gudrian Ricardo Lopes de Almeida, Jozimar Carlos Szczepanik, Alcir Luiz Dafre, Gabriela Cristina de Paula, Isabella A. Heinrich, Ariana Ern Schmitz, Mauricio P. Cunha, Barbara dos Santos, Rodrigo B. Leal, Ingrid Selhorst, Andreza Fabro de Bem
Publikováno v:
Molecular Neurobiology. 58:735-749
Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis that has been associated to aging, Alzheimer’s disease, and inflammation. Cell culture studies reported that MGO could impair the glyoxalase, thioredoxin, and