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Autor:
Vivian Dambeck, Dirk Balke, Paul Lingor, Uwe Michel, Vinicius Toledo Ribas, Lars Tatenhorst, Björn Friedhelm Vahsen, Mathias Bähr
Publikováno v:
Molecular Neurobiology. 57:685-697
Loss of nigrostriatal projections by axonal degeneration is a key early event in Parkinson's disease (PD) pathophysiology, being accountable for the lack of dopamine in the nigrostriatal system and resulting in motor symptoms such as bradykinesia, ri
Publikováno v:
Molecular Neurobiology. 55:6572-6588
All current treatments of Parkinson's disease (PD) focus on enhancing the dopaminergic effects and providing symptomatic relief; however, they cannot delay the disease progression. Filgrastim, a recombinant methionyl granulocyte colony-stimulating fa
Autor:
Sunil Bhurtel, Sina Shadfar, Yu-Gyeong Kim, Nikita Katila, Sunil Srivastav, Jin Tae Hong, Uttam Ojha, Gil-Saeng Jeong, Pil-Hoon Park, Sabita Neupane, Dong-Young Choi
Publikováno v:
Molecular Neurobiology. 55:554-566
Neurotrophic factors are essential for neuronal survival, plasticity, and development and have been implicated in the action mechanism of antidepressants. In this study, we assessed the neurotrophic factor-inducing and neuroprotective properties of a
Publikováno v:
Molecular Neurobiology. 54:4292-4302
Caspase family has been recognized to be involved in dopaminergic (DA) neuronal death and to exert an unfavorable role in Parkinson's disease (PD) pathology. Our previous study has revealed that caspase-1, as an important component of NLRP3 inflammas
Autor:
Jing Xiong, Jinsha Huang, Xiaowei Zhang, Zhaohui Zhang, Tao Wang, Zhenzhen Chen, Zhentao Zhang, Zhicheng Lin, Ling Liu, Chunnuan Chen, Nian Xiong, Guoxin Zhang, Jiaolong Yang
Publikováno v:
Molecular Neurobiology. 53:995-1008
Fenpropathrin is one of the widely used pyrethroids in agriculture and household and also reported to have neurotoxic effects in rodent models. In our Parkinson's disease (PD) clinic, there was a unique patient with a history of daily exposure to fen