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Autor:
Maria José Alves da Rocha, Carlos Henrique Rocha Catalão, Luís Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior
Publikováno v:
Molecular Neurobiology. 58:2133-2144
Sepsis promotes an inflammatory state in the central nervous system (CNS) that may cause autonomic, cognitive, and endocrine changes. Microglia, a resident immune cell of the CNS, is activated in several brain regions during sepsis, suggesting its pa
Publikováno v:
Molecular Neurobiology. 57:5130-5149
Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of effective treatment. Microglia are a major component of the innate immune system, and they respond to acute brain injury by activating and forming classic M1
Publikováno v:
Molecular Neurobiology. 57:5056-5068
Multiple lines of evidence have shown that neuroinflammation and autophagy are highly involved in the process of depression. Nobiletin (NOB) displays neuroprotective effects and anti-depressant-like effects. Given the evidence that NOB exerts anti-in
Publikováno v:
Mol Neurobiol
CYP2D metabolizes many drugs that act within the brain, and variable expression of CYP2D in the brain may alter local drug and metabolite levels sufficiently to affect behavioral responses. Transgenic mice that express human CYP2D6 (TG) were compared
Publikováno v:
Molecular Neurobiology. 57:1828-1846
Prior exposure to drugs of abuse may facilitate addiction. It has been described that pre-exposure to nicotine can increase or, contrarily, prevent conditioned place preference (CPP). Here, we evaluated the effect of nicotine pre-exposure on CPP perf
Autor:
Isaac H. Solomon, Sukrutha Chettimada, Benjamin B. Gelman, Susan Morgello, Robert J Gorelick, Vikas Misra, David R. Lorenz, Dana Gabuzda
Publikováno v:
Mol Neurobiol
Neurocognitive impairment (NCI) remains a significant cause of morbidity in human immunodeficiency virus (HIV)-positive individuals despite highly active antiretroviral therapy (HAART). White matter abnormalities have emerged as a key component of ag
Publikováno v:
Mol Neurobiol
Mitochondrial dysfunction and oxidative stress play a key role in ischemia/reperfusion (I/R) induced brain injury. We previously showed that ubiquilin-1 (Ubqln1), a ubiquitin-like protein, improves proteostasis and protects brains against oxidative s
Autor:
Siddiqul Islam, George E. Barreto, Dewan Md. Sumsuzzman, Sahab Uddin, Farhad Hossain, Bijo Mathew, G. M. Sala Uddin, Ghulam Md Ashraf
Publikováno v:
Molecular Neurobiology. 56:8255-8276
Melatonin, a pineal gland synthesized neurohormone is known as a multifunctioning pleiotropic agent which has a wide range of neuroprotective role in manifold age-related neurodegenerative disorders especially Alzheimer's diseases (AD). AD is a devas
Publikováno v:
Molecular Neurobiology. 56:7741-7753
The innate immune system and inflammatory response in the brain have critical impacts on the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD). In the central nervous system (CNS), the innate immune response is primar
Autor:
Pascal Romieu, Lamis Saad, Maxime Sartori, Sarah Pol Bodetto, Jean Zwiller, Patrick Anglard, Andries Kalsbeek
Publikováno v:
Molecular Neurobiology, 56, 5315-5331. Humana Press
Molecular neurobiology, 56(8), 5315-5331. Humana Press
Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2019, ⟨10.1007/s12035-018-1453-6⟩
Molecular neurobiology, 56(8), 5315-5331. Humana Press
Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2019, ⟨10.1007/s12035-018-1453-6⟩
Inhibitors of DNA methylation and orexin type-1 receptor antagonists modulate the neurobiological effects driving drugs of abuse and natural reinforcers by activating common brain structures of the mesolimbic reward system. In this study, we applied