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Publikováno v:
Molecular Neurobiology. 58:4628-4638
Drug addiction is a global health problem and continues to place an enormous financial burden on society. This addiction is characterized by drug dependence sensitization and craving. Morphine has been widely used for pain relief, but chronic adminis
Autor:
Alireza Zali, Fatemeh Rostami, Maryam Oraee-Yazdani, Ehsan Arefian, Masoud Soleimani, Saeed Oraee-Yazdani, Gelareh Shokri, Mohammadhosein Akhlaghpasand, Mina Soufi Zomorrod, Fatemeh Jamshidi-Adegani, Maryam Hafizi, Maryam Golmohammadi
Publikováno v:
Molecular Neurobiology. 58:4425-4436
Widespread investigation has revealed the promising ability of suicidal genes in the treatment of glioma tumors; nevertheless, promoting their effects relies on the ability to apply suitable vehicles and techniques. In this study, the safety and feas
Autor:
Xiaoming Huang, Xiaoshuai Ji, Rui Zhang, Dan Wang, Jun Sun, Qian Liu, Jingxia Tian, Zixiao Wang, Jiajia Gao, Dong He, Yanbang Wei, Qi Pang
Publikováno v:
Molecular Neurobiology. 58:3918-3937
In neonatal hypoxic-ischemic brain damage (HIBD), in addition to damage caused by hypoxia and ischemia, over-activation of inflammation leads to further deterioration of the condition, thus greatly shortening the optimal treatment time window. Ischem
Publikováno v:
Molecular Neurobiology
There is significant comorbidity of opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) in clinical populations. However, the neurobiological mechanisms underlying the relationship between chronic opioid use and withdrawal and develop
Infliximab Can Improve Traumatic Brain Injury by Suppressing the Tumor Necrosis Factor Alpha Pathway
Publikováno v:
Molecular Neurobiology. 58:2803-2811
Traumatic brain injury (TBI) has both high morbidity and mortality rates and can negatively influence physical and mental health, while also causing extreme burden to both individual and society. Hitherto, there is no effective treatment for TBI beca
Autor:
João Lopes, Rodrigo A. Cunha, Paula M. Canas, Ângelo R. Tomé, Henrique B. Silva, Ana Moreira-de-Sá, Francisco Q. Gonçalves
Publikováno v:
Molecular Neurobiology. 58:2543-2557
Angelman syndrome (AS) is a neurogenetic disorder involving ataxia and motor dysfunction, resulting from the absence of the maternally inherited functional Ube3a protein in neurons. Since adenosine A2A receptor (A2AR) blockade relieves synaptic and m
Autor:
Maria José Alves da Rocha, Carlos Henrique Rocha Catalão, Luís Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior
Publikováno v:
Molecular Neurobiology. 58:2133-2144
Sepsis promotes an inflammatory state in the central nervous system (CNS) that may cause autonomic, cognitive, and endocrine changes. Microglia, a resident immune cell of the CNS, is activated in several brain regions during sepsis, suggesting its pa
Publikováno v:
Mol Neurobiol
Cisplatin, a potent chemotherapeutic drug, induces ototoxicity, which limits its clinical utility. Cisplatin-induced oxidative stress plays a causal role in cochlear apoptosis while the consequent nitrative stress leads to the nitration of LIM domain
Publikováno v:
Molecular Neurobiology
Chronic adenosine A1R stimulation in hypoxia leads to persistent hippocampal synaptic depression, while unopposed adenosine A2AR receptor stimulation during hypoxia/reperfusion triggers adenosine-induced post-hypoxia synaptic potentiation (APSP) and
Autor:
Jucilene Freitas-Santos, Amanda Larissa Dias Pacheco, Ana Catarina Rezende Leite, Igor Santana de Melo, Reginaldo Correia Silva-Filho, Daniel Góes Leite Gitaí, Yngrid Mickaelli Oliveira dos Santos, Maisa de Araújo Costa, Robinson Sabino-Silva, Vanessa de Oliveira Silva, Alexandre Urban Borbely, Marcelo Duzzioni, Cibelle de Melo Bastos Cavalcante, Olagide W. Castro
Publikováno v:
Molecular Neurobiology. 58:1217-1236
Status epilepticus (SE) is defined as continuous and self-sustaining seizures, which trigger hippocampal neurodegeneration, mitochondrial dysfunction, oxidative stress, and energy failure. During SE, the neurons become overexcited, increasing energy