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Publikováno v:
Molecular Medicine Reports. 23
Rheumatoid arthritis (RA) is one of the most critical articular diseases, which is characterized by synovial hyperplasia and impaired quality of life. The clinical features of RA include chronic inflammation of the joints associated with synovial cel
Publikováno v:
Molecular Medicine Reports
Circular RNAs (circRNAs) serve important roles in tumorigenesis and may be used as novel molecular biomarkers for clinical diagnosis. However, the role and molecular mechanisms of circRNAs in cervical cancer (CC) remain unknown. In the present study,
Autor:
Zhiwei Hu, Dingyun Li, Yafei Ling, Ting Wang, Tao Zhang, Shengquan He, Jiajun Lai, Jian Zhang
Publikováno v:
Molecular Medicine Reports
The present study aimed to investigate the function of microRNA‑25 (miR‑25) in human colon cancer cell viability and migration in addition to the underlying possible mechanisms. miR‑25 expression was upregulated in patients with colon cancer co
Publikováno v:
Molecular Medicine Reports
Nasopharyngeal carcinoma (NPC) is a type of cancer originating in the nasopharynx. There are no NPC‑specific treatments available at present. Serpin peptidase inhibitor clade C member 1 (SERPINC1) serves roles in anticoagulation and anti‑inflamma
Publikováno v:
Molecular Medicine Reports
The present study aimed to investigate the expression of microRNA (miR)-133a in patients with or without acute myocardial infarction (AMI) following radical surgery for gastric cancer, and to explore its underlying mechanisms. Blood samples were coll
Publikováno v:
Molecular Medicine Reports. 23
Alzheimer's disease (AD) is a global health issue, but the precise underlying mechanism has not yet been elucidated. The present study aimed to integrate microRNA (miRNA or miR) and mRNA profiles of AD and identify hub genes via bioinformatics analys
Autor:
Jiayi Weng, Meifen Li, Juan Yin, Guidong Xu, Zhi Pang, Lan Yu, Ping Li, Kangyun Sun, Xinxin Yan, Qian Chen
Publikováno v:
Molecular Medicine Reports
Coronary artery disease (CAD) is a serious threat to human health and a major cause of mortality worldwide. Long noncoding RNAs (lncRNAs) affect the occurrence and development of CAD via the regulation of cell proliferation and apoptosis, inflammator
Publikováno v:
Molecular Medicine Reports
MicroRNA (miR)‑200b‑3p is downregulated in multiple human cancer types. Wnt signaling serves a role in human colorectal cancer (CRC). The present study aimed to examine the effect of miR‑200b‑3p on human CRC and its potential association with
Autor:
Huaizhi Wang, Yongsheng Ouyang, Yunchao Wang, Jiali Yang, Liangyu Yin, Xuejun Xu, Shixiang Guo, Jiayun Ge
Publikováno v:
Molecular Medicine Reports
Pancreatic cancer remains one of the most malignant tumors with a poor prognosis. Despite advances in diagnosis and treatment, no reliable biomarkers are available for clinical practice. Circular RNAs (circRNAs) are a novel class of endogenous non‑
Publikováno v:
Molecular Medicine Reports
Dysregulation of micro (mi)RNA-let-7 has been associated with the development and prognosis of multiple cancer types. Lin28, a RNA-binding protein, plays a conserved role in regulating the maturation of let-7 family proteins. However, few studies hav