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Publikováno v:
Molecular Medicine Reports.
Previous reports have indicated a potential link between microRNA (miR)‑214 and hypoxia. In the present study, the biological functions and potential mechanisms of miR‑214 were determined, as well as its correlation with HIF‑1α signaling in no
Publikováno v:
Molecular Medicine Reports.
Emerging evidence suggests that long noncoding RNAs (lncRNAs) serve a key role in malignant transformation, tumor progression and metastasis. Increased expression of lncRNA p53 upregulated regulator of P53 levels (PURPL) has been reported to promote
Autor:
Xiaopeng Cui, Yongwei Qin, Yan Chen, Jianxin Zhong, Weiguan Chen, Minhui Hua, Junming Yan, Meihong Sheng
Publikováno v:
Molecular Medicine Reports
MicroRNAs (miRNA/miRs) have been demonstrated to be critical post-transcriptional modulators of gene expression during tumorigenesis. Numerous miRNAs have been revealed to be downregulated in human epithelial ovarian cancer (EOC). In the present stud
Publikováno v:
Molecular Medicine Reports
Long noncoding RNAs (lncRNAs) serve important roles in the biology of autoimmune diseases and immune‑associated disorders. To identify lncRNAs specifically associated with psoriasis, the expression of lncRNAs from biopsies obtained from patients wi
Autor:
Bufeng Zhuang, Youshuang Cheng
Publikováno v:
Molecular Medicine Reports.
Dysregulated microRNAs (miRNAs/miRs) directly modulate the biological functions of non‑small cell lung cancer (NSCLC) cells and contribute to the initiation and progression of NSCLC; however, the specific roles and underlying mechanisms of the dysr
Publikováno v:
Molecular Medicine Reports.
Progressive renal fibrosis is a common complication of chronic kidney disease that results in end‑stage renal disorder. It is well established that several microRNAs (miRs) function as critical regulators implicated in fibrotic diseases. However, t
circRNA‑CER mediates malignant progression of breast cancer through targeting the miR‑136/MMP13 axis
Publikováno v:
Molecular Medicine Reports.
Chondrocyte extracellular matrix‑related circular RNAs (circRNA‑CER) have been demonstrated to be involved in various diseases. However, its role in the development of human breast cancer is not clearly understood. The aims of the present study w
Publikováno v:
Molecular Medicine Reports
Ras-Related Protein Rab-38 (RAB38), which belongs to the RAB family, is involved in the biogenesis of lysosome-related organelles and defense against certain microbial infections. However, the clinical significance and potential function of RAB38 in
Autor:
Congming Xiang, Caihong Sun, Xiqi Ding, Jian Sun, Guang Li, Yibin Zhou, Chengwen Sun, Ganglong Yang
Publikováno v:
Molecular medicine reports. 20(6)
MicroRNAs (miRNAs) are well established key players in tumorigenesis. Their emergence as potential diagnostic and prognostic biomarkers for cancer has demonstrated the importance of miRNAs in cancer biology. Although miR‑486 is implicated in many t
Autor:
Li-jun Ma, Hongmei Liu, Liming Zhao, Zhaihua Liu, Tingshu Jiang, Bao Liu, Zhida Liu, Xin-gang Hu
Publikováno v:
Molecular Medicine Reports.
MicroRNAs (miRs) are short, highly conserved small noncoding RNA molecules with fundamental roles in regulating gene expression. To identify miR biomarkers associated with idiopathic pulmonary fibrosis (IPF), the expression pattern of miRs in exosome