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Publikováno v:
Molecular Medicine Reports
Molecular classifications of gastric cancer (GC) by the Asian Cancer Research Group (ACRG) and The Cancer Genome Atlas Consortium (TCGA) are useful for diagnosis and treatment of GC. However, their clinical significance is unknown. The present study
Autor:
Hu Yiren, Wu Chen, Chen Dake, Rui Feng, Li Linjin, Bao Wenshuo, Xiaomin Xu, Chen Heyi, Zhu Jianlong
Publikováno v:
Molecular Medicine Reports
Prostate cancer (PCa) endangers the life and health of older men. Most PCa cases develop into castration‑resistant PCa (CRPC) within 2 years. At present, the molecular mechanisms of the occurrence and development of PCa and its transformation to CR
Publikováno v:
Molecular Medicine Reports
AT-rich interaction domain 1A (ARID1A) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) serve important roles in the formation and development of numerous malignancies including gastric cancer. Accumulating evidence ha
Publikováno v:
Molecular Medicine Reports
Gastric cancer (GC) is one of the most common malignancies of the digestive system. In diffuse‑type GC, differentiation is relatively poor, and the probability of distant metastasis and lymph node metastasis is high, resulting in poor clinical prog
Publikováno v:
Molecular Medicine Reports
Numerous genetic alterations associated with cancer progression have the potential to serve as biomarkers for the early diagnosis of cancer. Numerous studies have suggested that claudin proteins, which are the primary components of tight junction str
Autor:
Dan Bing, Yanbo Sun, Yanling Tao, Qingguo Chen, Liangqiang Zhou, Zhihui Du, Zhaogen Cai, Hanqi Chu, Jin Chen, Yun Liu, Chunchen Pan, Ting Tong
Publikováno v:
Molecular Medicine Reports. 16:4934-4940
Previous studies have demonstrated that elevated yes‑associated protein (YAP) expression is associated with tumor aggression and poor prognosis in various types of human cancer. However, the clinicopathological significance and the prognostic value
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to investigate the associations between adiponectin receptor 2 (AdipoR2) gene polymorphisms, AdipoR2 protein expression levels and the risk of colorectal cancer (CRC). From April 2012 to May 2015, 281 CRC patients (ca
Autor:
Haixin Qian, Rengen Fan, Cuifen Shi, Ping Chen, Yufeng Miao, Aihua Xia, Lige Chen, Hongqi Liu
Publikováno v:
Molecular Medicine Reports. 15:3099-3104
As demonstrated in previous studies, the phosphorylated form of 4E‑binding protein 1 (p‑4E‑BP1) may be a suitable tumor biomarker. The aim of the current study was to examine the expression status of p‑4E‑BP1 in colorectal cancer (CRC), in
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to investigate the prognostic significance of the expression of transcription factors, c-Fos, c-Jun and transmembrane protein CD147, in urothelial carcinoma of the bladder (UCB). The current study investigated the cli
Autor:
Aiqin Gao, Xiaosun Guo, Han Chen, Wenli Lin, Wei Gao, Yuping Sun, Qi Dang, Dong Yang, Juan Li, Jie Liu, Xiaoqing Li, Linlin Wang, Pei Zhang
Publikováno v:
Molecular Medicine Reports
Podoplanin and fibroblast growth factor (FGF) 1 have been detected more frequently in lung squamous cell carcinoma (SQCC) compared with lung adenocarcinoma. Furthermore, it has been previous demonstrated that FGF1 is located on the edge of tumor nest