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Publikováno v:
Molecular Medicine Reports
Myocardial injury is the primary manifestation of multiple organ dysfunction during sepsis, however, the mechanisms underlying sepsis‑induced myocardial injury remain unclear. Similarly, no effective therapeutics have yet been developed for myocard
Publikováno v:
Molecular Medicine Reports
Perioperative neurocognitive dysfunction (PND) is a prevalent neurological complication after anesthesia and surgery. Ginkgolide B (GB) has been suggested to improve lipopolysaccharide‑induced learning and memory impairment. The present study aimed
Publikováno v:
Molecular Medicine Reports
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes, which importantly contributes to the increased mortality of patients with diabetes. The development of DCM is accompanied by numerous pathological mechanisms, including oxidative st
Publikováno v:
Molecular Medicine Reports
The aim of the present study was to investigate the antioxidant mechanisms of dexmedetomidine against lung injury during intestinal ischemia reperfusion (IIR) in rats. The model of IIR-induced acute lung injury was established by occluding the superi
Autor:
Feng Zhang, Sun Dongdong, Yuehua Shi, Ye Yang, Jie Qian, Xiaoyan Liu, Yan Hu, Li Jiang, Bei-Bei Jia, Qinfen Zhang
Publikováno v:
Molecular Medicine Reports
Placental structural abnormalities and dysfunction in those with gestational diabetes mellitus (GDM) can lead to increased placental permeability, which is in turn related to a poorer maternal and fetal prognosis. The present study sought to assess w
Publikováno v:
Molecular Medicine Reports
Damage to the blood-brain barrier (BBB) resulting from systemic inflammation caused by surgical trauma is associated with cognitive dysfunction, and individuals with hyperlipidemia are more sensitive to such impairment. The present study was designed
Autor:
Daniel Cervantes-García, Eva Salinas, Adriana Guadalupe Cuellar-Juarez, Augusto Rojas-Martinez, Liseth Rubí Aldaba-Muruato, Gissela Borrego-Soto, Javier Ventura-Juárez, Martín Humberto Muñoz-Ortega
Publikováno v:
Molecular Medicine Reports
Liver fibrosis occurs in the presence of continuous insults, including toxic or biological agents. Novel treatments must focus on ceasing the progression of cellular damage, promoting the regeneration of the parenchyma and inhibition of the fibrotic
Autor:
Peijian Tong, Shanxing Zhang, Pinger Wang, Luwei Xiao, Qiang Mao, Hongfeng Ruan, Chengliang Wu, Hongting Jin, Taotao Xu, Yangjun Lao, Li Zhou
Publikováno v:
Molecular Medicine Reports
Long-term administration of glucocorticoid hormones is considered one of predominant pathological factors inducing osteonecrosis of the femoral head (ONFH) development and progression, in which reduction of blood supply leads to a progressive bone lo
Publikováno v:
Molecular Medicine Reports
Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia-induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial fun
Publikováno v:
Molecular Medicine Reports. 16:9131-9136
Butylphthalide, a component extracted from seeds of Chinese celery, is an effective neuroprotective agent used for the treatment of ischemic stroke and dementia. Diabetes may cause central nervous system damage, and diabetes is closely associated wit