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Upregulated microRNA-330-3p promotes calcification in the bicuspid aortic valve via targeting CREBBP
Autor:
Chen Su, Haoliang Sun, Buqing Ni, Jiaxi Gu, Junjie Du, Rui Zheng, Yaojun Guo, Yongfeng Shao, Hao Liu, Keshuai He
Publikováno v:
Molecular Medicine Reports
One key risk factor of aortic valve stenosis in clinical practice is bicuspid aortic valve (BAV). Increasing evidence indicates that numerous microRNAs (miRs/miRNAs) are involved in BAV calcification via their target genes. miR‑330‑3p was found t
Publikováno v:
Molecular Medicine Reports
Molecular classifications of gastric cancer (GC) by the Asian Cancer Research Group (ACRG) and The Cancer Genome Atlas Consortium (TCGA) are useful for diagnosis and treatment of GC. However, their clinical significance is unknown. The present study
Publikováno v:
Molecular Medicine Reports
Colorectal cancer (CRC) is one of the most fatal types of cancer worldwide. This study aimed to determine the predictive and prognostic values of cell division cycle associated protein 7 (CDCA7) in CRC. Firstly, the relationship between CDCA7 and CRC
Publikováno v:
Molecular Medicine Reports
Histone deacetylase 9 (HDAC9) is involved in a variety of malignant tumors, and leads to malignant tumor development and poor prognosis. However, the association between HDAC9 expression, and the prognosis and clinicopathological features of patients
Autor:
Hu Yiren, Wu Chen, Chen Dake, Rui Feng, Li Linjin, Bao Wenshuo, Xiaomin Xu, Chen Heyi, Zhu Jianlong
Publikováno v:
Molecular Medicine Reports
Prostate cancer (PCa) endangers the life and health of older men. Most PCa cases develop into castration‑resistant PCa (CRPC) within 2 years. At present, the molecular mechanisms of the occurrence and development of PCa and its transformation to CR
Autor:
He-Qing Huang, Hongwei Jiang, Xinhua Zeng, Zhijian Yan, Sheng Zhang, Huiqin Zhuo, Huifang Peng
Publikováno v:
Molecular Medicine Reports
Hepatocellular carcinoma (HCC) accounts for ~85% of primary liver cancer cases and is a leading cause of mortality worldwide. Effective early diagnosis is difficult for HCC; however, effective biomarkers may be beneficial for diagnosis. In the curren
Publikováno v:
Molecular Medicine Reports
AT-rich interaction domain 1A (ARID1A) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) serve important roles in the formation and development of numerous malignancies including gastric cancer. Accumulating evidence ha
Autor:
Qixiang Shao, Miao Chen, Meina Yan, Rong Shen, Xiaodong Lu, Genbao Shao, Yao He, Xiaoming Zhou, Hui Wang, Xiaoge Ni, Xiaokun Chen, Xinxin Yang, Peifang Yang
Publikováno v:
Molecular Medicine Reports
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. LIN28 homolog A (LIN28A) is a RNA-binding protein, which serves a fundamental role in cell development and pluripotency. Polo-like kinase 4 (PLK4) is a member of the polo-li
Publikováno v:
Molecular Medicine Reports
Gastric cancer (GC) is one of the most common malignancies of the digestive system. In diffuse‑type GC, differentiation is relatively poor, and the probability of distant metastasis and lymph node metastasis is high, resulting in poor clinical prog
Publikováno v:
Molecular Medicine Reports
Numerous genetic alterations associated with cancer progression have the potential to serve as biomarkers for the early diagnosis of cancer. Numerous studies have suggested that claudin proteins, which are the primary components of tight junction str