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Autor:
Philip C.N. Chiu, William S.B. Yeung, Cheuk-Lun Lee, Ying Wang, Pak Chung Ho, Panyu Chen, Kevin K.W. Lam, Si Mei, Weie Zhao, C. Fang
Publikováno v:
Molecular Human Reproduction. 25:458-470
Human spermatozoa can fertilize an oocyte only after post-testicular maturation and capacitation. These processes involve dynamic modification and reorganization of the sperm plasma membrane, which allow them to bind to the zona pellucida (ZP) of the
Publikováno v:
Molecular Human Reproduction
Human zygotes are difficult to obtain for research because of limited resources and ethical debates. Corrected human tripronuclear (ch3PN) zygotes obtained by removal of the extra pronucleus from abnormally fertilized tripronuclear (3PN) zygotes are
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Peroxiredoxins (PRDXs) are antioxidant enzymes proven to control the levels of reactive oxygen species (ROS) and to avoid oxidative damage in the spermatozoon. Previously, we have shown that low amounts of PRDXs are associated with male infertility a
Publikováno v:
Molecular Human Reproduction. 22:499-511
STUDY HYPOTHESIS The transforming growth factor (TGF)-β/β-catenin pathway is involved in granulocytic myeloid-derived suppressor cell (G-MDSCs)-induced Foxp3 expression in CD4(+)CD25(-)T cells, which plays an essential role in maintaining feto-mate
Autor:
Laurie Betts, Brenda Temple, Mischa Machius, Deborah A. O'Brien, Michael J. Miley, Polina V. Danshina, Rafael Rojas, Weidong Qu
Publikováno v:
Molecular Human Reproduction. 22:410-426
STUDY HYPOTHESIS Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selec
Publikováno v:
Molecular Human Reproduction. 22:93-109
Study hypothesis Given the importance of the chaperone Heat Shock Protein A2 (HSPA2) in the regulation of male fertility, this study aimed to identify and characterize additional proteins that may rely on the activity of this chaperone in human sperm
Autor:
Kim-Gwendolyn Dietrich, Artur Mayerhofer, Charis Drummer, Thomas Fröhlich, R. Behr, Nina Schmid, Jan B. Stöckl, Florian Flenkenthaler, Frank-Michael Köhn, J. U. Schwarzer, Guy Arnold
Publikováno v:
Molecular human reproduction. 24(8)
Study question Are monkey testicular peritubular cells (MKTPCs) from the common marmoset monkey (Callithrix jacchus) a suitable translational model for the study of human testicular peritubular cells (HTPCs)? Summary answer MKTPCs can be isolated and
Autor:
Kathryn L. Gatford, Prabha H. Andraweera, Claire T. Roberts, Shalem Leemaqz, Darryl L. Russell, Lesley M. E. McCowan, S. D. Thompson, Gustaaf A. Dekker
Publikováno v:
Molecular Human Reproduction. 21:745-752
Being born small for gestational age (SGA) increases the risk for adverse perinatal outcomes and later life vascular and metabolic disorders. The insulin family plays a vital role in intrauterine growth. We investigated the association of functional
Autor:
Rafael Oliva, Rubén Azpiazu, Tanya Vavouri, Josep Maria Estanyol, Judit Castillo, Alexandra Amaral, Josep Lluís Ballescà
Publikováno v:
Molecular Human Reproduction. 20:1041-1053
The mammalian spermatozoon has a unique chromatin structure where the majority of DNA is packaged by protamines, while a small fraction (∼8%) remains associated with nucleosomes. However, the chromatin affinity and repertoire of the additional prot
Publikováno v:
Molecular human reproduction. 23(2)
STUDY QUESTION Does oxidative stress compromise the protein expression of heat shock protein A2 (HSPA2) in the developing germ cells of the mouse testis? SUMMARY ANSWER Oxidative stress leads to the modification of HSPA2 by the lipid aldehyde 4-hydro