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Autor:
Anders Rehfeld
Publikováno v:
Molecular Human Reproduction. 26:816-824
The sperm-specific Ca2+ channel CatSper (cation channel of sperm) is vital for male fertility. Contradictory findings have been published on the regulation of human CatSper by the endogenous steroids estradiol, testosterone and hydrocortisone, as wel
Autor:
Bastian Popper, Frank-Michael Köhn, Nadine Mundt, Ulrich Pickl, Katja Eubler, Matthias Trottmann, Marc Spehr, Lars Kunz, Artur Mayerhofer, Lena Walenta, Matti Poutanen, Annika Missel, Hanna Heikelä, Leena Strauss
Publikováno v:
Molecular Human Reproduction. 27
Extracellular ATP has been described to be involved in inflammatory cytokine production by human testicular peritubular cells (HTPCs). The ectonucleotidases ENTPD1 and NT5E degrade ATP and have been reported in rodent testicular peritubular cells. We
Autor:
Pilar Flores-Espinosa, M Déciga-García, E Preciado-Martínez, Zaga-Clavellina, Addy Cecilia Helguera-Repetto, Goffin, Andrea Olmos-Ortiz, L Bermejo-Martínez, Ismael Mancilla-Herrera, Braulio Quesada-Reyna, Claudine Irles, Lorenza Díaz
Publikováno v:
Molecular Human Reproduction
Prolactin (PRL) plays an important role in trophoblast growth, placental angiogenesis and immunomodulation within the feto-maternal interface, where different cell types secrete PRL and express its receptor. During pregnancy, inflammatory signalling
Publikováno v:
Molecular Human Reproduction. 27
Preeclampsia (PE) is a gestational disease, which seriously impairs maternal and infant health. However, the pathogenesis of PE remains unclear. The aromatase (CYP19A1) in placenta converts androgens from maternal and fetal adrenal glands to estrogen
Autor:
Zhiping Ge, Qing Zuo, Min Zhang, Yetao Xu, Tianjun Wang, Tingting Zhang, Ziyan Jiang, Shiyun Huang, Yanfeng Zou
Publikováno v:
Molecular Human Reproduction. 27
Preeclampsia (PE) is a hypertensive disorder that occurs during pregnancy. Low-dose aspirin is used to reduce the occurrence of early-onset PE; however, the mechanisms are not clear. The aim of this study was to reveal the underlying mechanism of asp
Autor:
Blanche Capel, Rachel A. Williamson Taylor, Michael Czerwinski, Erika Segear Johnson, Iordan S Batchvarov, Ximena M. Bustamante-Marin, Sally Kornbluth
Publikováno v:
Molecular Human Reproduction. 22:1-10
STUDY QUESTION Can host fertility be rescued by grafting of a fragment of a healthy ovary soon after chemotherapy? SUMMARY ANSWER We found that grafting a green fluorescent protein (GFP)-positive fragment from a healthy isogenic ovary to the left ova
Autor:
Guijun Yan, Qun Zhang, Lijun Ding, Yun Cao, Yali Hu, Mei Zhang, Zhenyu Diao, Ruiwei Jiang, Xi Cheng, Junxia Wang, Haixiang Sun, Hui Zhang, Yue Jiang
Publikováno v:
Molecular Human Reproduction. 22:655-668
Study question How do NR4A receptors drive decidualization of human endometrial stromal cells (hESCs)? Summary answer NR4A receptors modulate endometrial decidualization by transcriptional activation of FOXO1A, and in adenomyosis patients, the reduce
Publikováno v:
Young, V J, Ahmad, S F, Brown, J K, Duncan, W C & Horne, A W 2016, ' ID2 mediates the transforming growth factor-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis ', Molecular Human Reproduction . https://doi.org/10.1093/molehr/gaw045
STUDY QUESTION: Is inhibitor of DNA binding protein 2 (ID2) a mediator of the transforming growth factor (TGF)-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis?STUDY FINDING: The TGF-β1-induced changes in the metabo
Publikováno v:
Hudson, C A, McArdle, C A & López Bernal, A 2016, ' Steroid receptor co-activator interacting protein (SIP) mediates EGF-stimulated expression of the prostaglandin synthase COX2 and prostaglandin release in human myometrium ', Molecular Human Reproduction, vol. 22, no. 7, pp. 512-525 . https://doi.org/10.1093/molehr/gaw031
Study hypothesis Steroid receptor coactivator interacting protein (SIP/KANK2) is involved in regulating the expression of the prostaglandin (PG)-endoperoxide synthase 2 (PTGS2; also known as cyclo-oxygenase 2, COX2) and PG release in human myometrium
Publikováno v:
Molecular Human Reproduction. 22:475-484
STUDY HYPOTHESIS We hypothesized that a better discrimination between follicles containing oocytes with high developmental competence and those containing oocytes with low competence, based on a combination of a follicle's size and transcriptomic sig