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Autor:
Grant Buchanan, Luke A. Selth, Tiffany J. Harris, Stephen N. Birrell, Wayne D. Tilley, Eleanor F. Need
Publikováno v:
Molecular Endocrinology. 26:1941-1952
The cellular response to circulating sex steroids is more than the sum of individual hormone actions, instead representing an interplay between activities of the evolutionarily related steroid hormone receptors. An example of this interaction is in b
Autor:
Jonathan A. Javitch, Matthew Freeby, Norman R. Simpson, Rudolph L. Leibel, Steven Burroughs, Zachary Freyberg, Paul L. Harris, Antonella Maffei
Publikováno v:
Molecular endocrinology (Baltim. Md.) 26 (2012): 1757–1772. doi:10.1210/me.2012-1101
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
info:cnr-pdr/source/autori:Simpson N, Maffei A, Freeby M, Burroughs S, Freyberg Z, Javitch J, Leibel R.L., Harris P.E./titolo:Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro/doi:10.1210%2Fme.2012-1101/rivista:Molecular endocrinology (Baltim. Md.)/anno:2012/pagina_da:1757/pagina_a:1772/intervallo_pagine:1757–1772/volume:26
We describe a negative feedback autocrine regulatory circuit for glucose-stimulated insulin secretion in purified human islets in vitro. Using chronoamperometry and in vitro glucose-stimulated insulin secretion measurements, evidence is provided that
Autor:
Antonio Brunetti, Monica Fedele, Daniela Foti, Katiuscia Possidente, Eusebio Chiefari, Stefania Iiritano, Maria T. Nevolo, Valeria Ventura, Alfredo Fusco, Adelaide Greco, Aurora Nocera, Giuseppe Brunetti, Manfredi Greco, Biagio Arcidiacono
Publikováno v:
Molecular Endocrinology. 26:1578-1589
We previously showed that loss of the high mobility group A1 (HMGA1) protein expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major target tissues of insulin action, causing a type 2-
Publikováno v:
Molecular Endocrinology. 26:1339-1355
The proglucagon gene is expressed not only in the pancreas and intestine but also in the hypothalamus. Proglucagon-derived peptides have emerged as potential regulators of energy homeostasis. Whether leptin, insulin, or cAMP activation controls progl
Autor:
Helmut Grasberger, Olga Barca Mayo, Mia C. Weiss, Samuel Refetoff, Xavier De Deken, Xiao Hui Liao, Houssam Raad
Publikováno v:
Molecular Endocrinology. 26:481-492
Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen peroxide (H(2)O(2)) release of epithelial cells. Specific maturation factors (DUOXA1 and DUOXA2
Autor:
Jonna Frasor, Sarah C. Baumgarten
Publikováno v:
Molecular Endocrinology. 26:360-371
Approximately 75% of breast tumors express the estrogen receptor (ER), and women with these tumors will receive endocrine therapy. Unfortunately, up to 50% of these patients will fail ER-targeted therapies due to either de novo or acquired resistance
Autor:
Shinichi Yamashita, Chawnshang Chang, Chih-Rong Shyr, Shuyuan Yeh, Kuo Pao Lai, Spencer Vitkus
Publikováno v:
Molecular Endocrinology. 26:52-66
Using the cre-loxP system, we generated a new mouse model [double stromal androgen receptor knockout (dARKO)] with selectively deleted androgen receptor (AR) in both stromal fibroblasts and smooth muscle cells, and found the size of the anterior pros
Publikováno v:
Molecular Endocrinology. 25:2041-2053
Overexpression of steroid receptor coactivator (SRC)-1 and SRC-3 is associated with cancer initiation, metastasis, advanced disease, and resistance to chemotherapy. In most of these cases, SRC-1 and SRC-3 have been shown to promote tumor cell growth
Autor:
Christopher M. Henstridge, Nariman Balenga, Julia Kargl, Clara Andradas, Maria Waldhoer, Cristina Sánchez, Andrew J. Brown, Andrew J. Irving
Publikováno v:
Molecular Endocrinology. 25:1835-1848
Emerging data suggest that off-target cannabinoid effects may be mediated via novel seven-transmembrane spanning/G protein-coupled receptors. Due to its cannabinoid sensitivity, the G protein-coupled receptor 55 (GPR55) was recently proposed as a can
Autor:
Inez Rogatsky, Jamie R. Flammer
Publikováno v:
Molecular Endocrinology. 25:1075-1086
For decades, natural and synthetic glucocorticoids (GC) have been among the most commonly prescribed classes of immunomodulatory drugs. Their unsurpassed immunosuppressive and antiinflammatory activity along with cost-effectiveness makes these compou