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Autor:
Enming Zhang, Erik Renström, Thomas Reinbothe, Clemens Lewold, Pawel Buda, Satadal Barik, Johan Helgeson, Vini Nagaraj, Abdulla S. Kazim, Stefan Wennmalm
Publikováno v:
Molecular Endocrinology
Elevated basal insulin secretion under fasting conditions together with insufficient stimulated insulin release is an important hallmark of type 2 diabetes, but the mechanisms controlling basal insulin secretion remain unclear. Membrane rafts exist i
Publikováno v:
Molecular Endocrinology. 30:402-416
The arcuate nucleus of the hypothalamus represents a key center for the control of appetite and feeding through the regulation of 2 key neuronal populations, notably agouti-related peptide/neuropeptide Y and proopimelanocortin (POMC)/cocaine- and amp
Publikováno v:
Molecular Endocrinology. 29:1787-1791
Recently, several LH/human chorionic gonadotropin (hCG) receptor-independent activities for hCG have been described, including activation of the TGF-β receptor (TGFβR) by hyperglycosylated hCG and stimulation of trophoblast invasion. Because the hC
Autor:
Raghavendra G. Mirmira, Medha Priyadarshini, Charles R. Mackay, Thierry Alquier, Annette Gilchrist, Helena Mancebo, Barton Wicksteed, Vincent Poitout, Miles Fuller, Stephanie R. Villa, Brian T. Layden
Publikováno v:
Molecular Endocrinology. 29:1055-1066
G protein-coupled receptors have been well described to contribute to the regulation of glucose-stimulated insulin secretion (GSIS). The short-chain fatty acid-sensing G protein-coupled receptor, free fatty acid receptor 2 (FFAR2), is expressed in pa
Autor:
Sabire Özcan
Publikováno v:
Molecular Endocrinology. 28:1922-1933
MicroRNAs are small noncoding ribonucleotides that regulate mRNA translation or degradation and have major roles in cellular function. MicroRNA (miRNA) levels are deregulated or altered in many diseases. There is overwhelming evidence that miRNAs als
Autor:
Yuko Ishido, Aya Yoshihara, Donald F. Sellitti, Yuqian Luo, Akira Kawashima, Takeshi Akama, Akito Tanoue, Kazuaki Nakamura, Kazunari Tanigawa, Koichi Suzuki
Publikováno v:
Molecular Endocrinology. 28:368-379
Thyroglobulin (Tg), stored in the follicular lumen, has also been shown recently to perform two unexpected roles: as an autocrine negative-feedback suppressor of thyroid function in the presence of TSH and as a potent inducer of thyroid cell growth i
Autor:
Ulrike Henrion, Martin Fraunholz, Behnam Hessabi, Robert Smail Jack, Annett Ostmann, Anke Karkour, Meike Dahlhaus, Piotr Grabarczyk, Reinhard Walther, Gabriele Wolf, Bernd Giese
Publikováno v:
Molecular Endocrinology. 24:2331-2342
The transcriptional transactivator Pax6 binds the pancreatic islet cell-specific enhancer sequence (PISCES) of the rat insulin I gene. However the human, mouse, and rat insulin gene II promoters do not contain a PISCES element. To analyze the role of
Autor:
Gary L. Firestone, Shyam N. Sundar
Publikováno v:
Molecular Endocrinology. 23:1940-1947
Indole-3-carbinol and its diindole condensation product 3-3'-diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented th
Autor:
Hideaki Kaneto, Yoshimitsu Yamasaki, Itaru Kojima, Taka-aki Matsuoka, Masatsugu Hori, Eva Henderson, Takeshi Miyatsuka, Roland Stein, Munehide Matsuhisa, Dan Kawamori
Publikováno v:
Molecular Endocrinology. 21:2764-2774
Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet
Autor:
Michelle M. Tabb, Bruce Blumberg
Publikováno v:
Molecular Endocrinology. 20:475-482
Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that mimic or block the transcriptional activation elicited by naturally circulating steroid hormones by binding to steroid hormone receptors. For example, the Food Quality