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Autor:
Karen L. Chen, Sarah Li, Yiru Chen Zhao, Alexander E. Lipka, Partha S. Ray, Eylem Kulkoyluoglu, Rebecca L. Smith, Tania Ray, Jamie N. Holloway, Kadriye Hieronymi, Yosef Landesman, Zeynep Madak-Erdogan, Kinga Wrobel
Publikováno v:
Molecular Endocrinology
Most breast cancer deaths occur in women with recurrent, estrogen receptor (ER)-α(+), metastatic tumors. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα (+) tumors can be re
Autor:
Bert W. O'Malley
Publikováno v:
Molecular Endocrinology. 30:1015-1018
Autor:
Paul R. Thompson, Aaron Muth, Shaihla A. Khan, Brian S. Edwards, Amy M. Navratil, Brian D. Cherrington
Publikováno v:
Molecular Endocrinology. 30:1081-1091
Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent
Autor:
Shingo Arakawa, Masahiko Negishi, Shogo Takahashi, Tatsuya Sueyoshi, Frank J. Gonzalez, Takuyu Hashiguchi
Publikováno v:
Molecular Endocrinology. 30:1070-1080
Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either d
Publikováno v:
Molecular Endocrinology. 30:977-987
For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. He
Autor:
Do-Geun Kim, Mark S. Roberson, Amy M. Navratil, Abigail R. Dowling, Jessica L. Brown, Margaret S. Bynoe, Jianjun Xie, Kurt Scavelli, Krystal Allen-Worthington, Iain J. Clarke, Alexa M. Edmunson, Hojean Yoon
Publikováno v:
Molecular Endocrinology. 30:996-1011
Fertility in mammals requires appropriate communication within the hypothalamic-pituitary-gonadal axis and the GnRH receptor (GnRHR) is a central conduit for this communication. The GnRHR resides in discrete membrane rafts and raft occupancy is requi
Publikováno v:
Molecular Endocrinology. 30:905-916
Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in perman
Autor:
Cheryl L. Walker, Mario Medvedovic, Shuk-Mei Ho, Rebecca Lee Yean Wong, Cristian Coarfa, Ali Shilatifard, Lindsey S. Treviño, Bert W. O’Malley, Jing Chen, Jianjun Shen, Quan Wang, Charles E. Foulds
Publikováno v:
Molecular Endocrinology. 30:856-871
Tissue and organ development is a time of exquisite sensitivity to environmental exposures, which can reprogram developing tissues to increase susceptibility to adult diseases, including cancer. In the developing prostate, even brief exposure to endo
Publikováno v:
Molecular Endocrinology. 30:917-924
Endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of diabetes and the associated β-cell apoptosis. Although microRNAs (miRNAs) have been widely studied in various diseases including diabetes, the role of miRNAs in ER stre
Autor:
Cheryl L. Walker
Publikováno v:
Molecular Endocrinology. 30:848-855
The epigenome undergoes significant remodeling during tissue and organ development, which coincides with a period of exquisite sensitivity to environmental exposures. In the case of endocrine-disrupting compounds (EDCs), exposures can reprogram the e