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Autor:
Sunamita S. Leming, Rachel Larder, Jason D. Meadows, Huimin Xie, Crystal Trang, Shannon W. Davis, Chiara Maruggi, Pamela L. Mellon, Susan L. Mayo, Hanne M. Hoffmann
Publikováno v:
Molecular Endocrinology. 29:842-855
Sine oculis-related homeobox 3 (SIX3) and SIX6, 2 closely related homeodomain transcription factors, are involved in development of the mammalian neuroendocrine system and mutations of Six6 adversely affect fertility in mice. We show that both small
Autor:
Suyeon Hwang, Jung Ok Lee, Jeong Hyun Kim, Jong Il Choi, Sun Hwa Park, Yong Woo Lee, Hyeon Soo Kim, Nami Kim, Hye Jeong Lee, Su Jin Kim, Hyung Ip Kim, Joong Kwan Kim, Yoonji Oh
Publikováno v:
Molecular Endocrinology. 29:873-881
Irisin is a novel myokine produced by skeletal muscle. However, its metabolic role is poorly understood. In the present study, irisin induced glucose uptake in differentiated skeletal muscle cells. It increased AMP-activated protein kinase (AMPK) pho
Autor:
Yasuhiro Kyono, Joseph R. Knoedler, Laurent M. Sachs, Xiaoan Ruan, Ronald M. Bonett, Robert J. Denver, Pia Bagamasbad, Yijun Ruan, Samhitha Raj, Nicolas Buisine
Publikováno v:
Molecular Endocrinology. 29:856-872
Cooperative, synergistic gene regulation by nuclear hormone receptors can increase sensitivity and amplify cellular responses to hormones. We investigated thyroid hormone (TH) and glucocorticoid (GC) synergy on the Krüppel-like factor 9 (Klf9) gene,
Autor:
Esther Bolanis, Theodore R. Holman, Raghavendra G. Mirmira, Jerry L. Nadler, Sarah A. Tersey, David J. Maloney
Publikováno v:
Molecular Endocrinology. 29:791-800
The insulin producing islet β-cells have increasingly gained attention for their role in the pathogeneses of virtually all forms of diabetes. Dysfunction, de-differentiation, and/or death of β-cells are pivotal features in the transition from normo
Publikováno v:
Molecular Endocrinology. 29:682-692
Type 2 diabetes mellitus (T2DM) is characterized by pancreatic islet failure due to loss of β-cell secretory function and mass. Studies have identified a link between a variance in the gene encoding melatonin (MT) receptor 2, T2DM, and impaired insu
Publikováno v:
Molecular Endocrinology. 29:777-787
Glucose regulation of pancreatic α-cell Ca(2+) entry through voltage-dependent Ca(2+) channels is essential for normal glucagon secretion and becomes defective during the pathogenesis of diabetes mellitus. The 2-pore domain K(+) channel, TWIK-relate
Autor:
Rona de la Vega, Yueshui Zhao, Song Li, Peipei Lu, Meishu Xu, Wen Xie, Qiuqiong Cheng, Rhobert W. Evans, Jinhan He, Grace L. Guo, Yuka Inaba, Ramalinga Kuruba
Publikováno v:
Molecular Endocrinology. 29:571-582
The nuclear receptor farnesoid X receptor (FXR) (nuclear receptor subfamily 1, group H, member 4, or NR1H4) is highly expressed in the liver and intestine. Previous reports have suggested beneficial functions of FXR in the homeostasis of bile acids,
Autor:
Xiulong Song, Yuan Chen, Ruchi Verma, Alex Vasilenko, Stephanie Shiffka, Bingfang Yan, Ruitang Deng, Leila Valanejad, Leeza Hargreaves, Christina Nadolny, Sangmin You
Publikováno v:
Molecular Endocrinology. 29:613-626
Among diseases unique to pregnancy, intrahepatic cholestasis of pregnancy is the most prevalent disorder with elevated serum bile acid levels. We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) thro
Publikováno v:
Molecular Endocrinology. 29:597-612
Defects in the Lhx4, Lhx3, and Pitx2 genes can cause combined pituitary hormone deficiency and pituitary hypoplasia in both humans and mice. Not much is known about the mechanism underlying hypoplasia in these mutants beyond generally increased cell
Publikováno v:
Molecular Endocrinology. 29:518-527
In vitro slice studies have revealed that there are significant differences in the spontaneous firing activity between anteroventral periventricular/periventricular preoptic nucleus (AVPV/PeN) and arcuate nucleus (ARC) kisspeptin (Kiss1) neurons in f