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Autor:
Karen L. Chen, Sarah Li, Yiru Chen Zhao, Alexander E. Lipka, Partha S. Ray, Eylem Kulkoyluoglu, Rebecca L. Smith, Tania Ray, Jamie N. Holloway, Kadriye Hieronymi, Yosef Landesman, Zeynep Madak-Erdogan, Kinga Wrobel
Publikováno v:
Molecular Endocrinology
Most breast cancer deaths occur in women with recurrent, estrogen receptor (ER)-α(+), metastatic tumors. There is a critical need for therapeutic approaches that include novel, targetable mechanism-based strategies by which ERα (+) tumors can be re
Publikováno v:
Molecular Endocrinology. 30:977-987
For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. He
Autor:
Do-Geun Kim, Mark S. Roberson, Amy M. Navratil, Abigail R. Dowling, Jessica L. Brown, Margaret S. Bynoe, Jianjun Xie, Kurt Scavelli, Krystal Allen-Worthington, Iain J. Clarke, Alexa M. Edmunson, Hojean Yoon
Publikováno v:
Molecular Endocrinology. 30:996-1011
Fertility in mammals requires appropriate communication within the hypothalamic-pituitary-gonadal axis and the GnRH receptor (GnRHR) is a central conduit for this communication. The GnRHR resides in discrete membrane rafts and raft occupancy is requi
Publikováno v:
Molecular Endocrinology. 30:905-916
Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in perman
Autor:
Cheryl L. Walker, Mario Medvedovic, Shuk-Mei Ho, Rebecca Lee Yean Wong, Cristian Coarfa, Ali Shilatifard, Lindsey S. Treviño, Bert W. O’Malley, Jing Chen, Jianjun Shen, Quan Wang, Charles E. Foulds
Publikováno v:
Molecular Endocrinology. 30:856-871
Tissue and organ development is a time of exquisite sensitivity to environmental exposures, which can reprogram developing tissues to increase susceptibility to adult diseases, including cancer. In the developing prostate, even brief exposure to endo
Publikováno v:
Molecular Endocrinology. 30:917-924
Endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of diabetes and the associated β-cell apoptosis. Although microRNAs (miRNAs) have been widely studied in various diseases including diabetes, the role of miRNAs in ER stre
Autor:
Lutz Schomburg, Josef Köhrle, Laura Kalveram, Annette Grüters-Kieslich, Heike Biebermann, Mariusz W. Szkudlinski, Gunnar Kleinau
Publikováno v:
Molecular Endocrinology. 30:954-964
Naturally occurring thyrotropin (TSH) mutations are rare, which is also the case for the homologous heterodimeric glycoprotein hormones (GPHs) follitropin (FSH), lutropin (LH), and choriogonadotropin (CG). Patients with TSH-inactivating mutations pre
Autor:
Shu-Ching M. Wang, Zewen K. Tuong, Emily Shao, Joel M. Goode, Tae Gyu Oh, George E.O. Muscat, Michael A. Pearen
Publikováno v:
Molecular Endocrinology. 30:660-676
Skeletal muscle remodels metabolic capacity, contractile and exercise phenotype in response to physiological demands. This adaptive remodeling response to physical activity can ameliorate/prevent diseases associated with poor diet and lifestyle. Our
Autor:
Christopher B. Newgard, Anna Tsimelzon, Susan G. Hilsenbeck, Robert Stevens, Olga Ilkayeva, James R. Bain, Anthony R. Means, Thomas J. Ribar, Brian York, Christopher R. Means, Kathrina L. Marcelo
Publikováno v:
Molecular Endocrinology. 30:557-572
A number of epidemiological studies have implicated calcium (Ca(2+)) signaling as a major factor in obesity that contributes to aberrant systems metabolism. Somewhat paradoxically, obesity correlates with decreased circulating Ca(2+) levels, leading
Autor:
Jacqueline F. Rivera, Safia Costes, Jonathan D. Hoang, Alexandra E. Butler, Tatyana Gurlo, Megan Cory, Peter C. Butler
Publikováno v:
Molecular endocrinology (Baltimore, Md.), vol 30, iss 4
The islet in type 2 diabetes is characterized by β-cell loss, increased β-cell apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). When protein misfolding protective mechanisms are overcome, human IAPP (h-IAPP) forms membran