Zobrazeno 81 - 90
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Autor:
Jennifer Rieusset, Silvia I. Anghel, Walter Wahli, Pierre Chambon, Daniel Metzger, Pascal Escher, Béatrice Desvergne, Liliane Michalik, Nguan Soon Tan, Josiane Seydoux
Publikováno v:
Molecular Endocrinology. 18:2363-2377
The peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in fat tissue development and physiology. Mutations in the gene encoding this receptor have been associated to disorders in lipid metabolism. A thorough investigation of mi
Publikováno v:
Molecular Endocrinology. 18:2279-2290
Regulation of insulin gene expression in response to increases in blood glucose levels is essential for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose stimulates insulin gene transcription are not known. We hav
Publikováno v:
Molecular Endocrinology. 18:1670-1686
Previous studies have shown that the synthesis and stability of milk protein mRNAs are regulated by lactogenic hormones. We demonstrate here in cultured mouse mammary epithelial cells (CID 9) that insulin plus prolactin also synergistically increases
Publikováno v:
Molecular Endocrinology. 18:1396-1410
Estrogen receptor alpha (ERalpha) negative breast tumors often present with enhanced expression and/or activation of growth factor receptors, resulting in increased growth factor signaling and hyperactivation of MAPK (ERK1 and ERK2). We have pre-viou
Autor:
Wolfgang Schmid, Christoph Kellendonk, Christian Opherk, Andreas Schulze, François Tronche, Günther Schütz, Dirk Kohlmüller
Publikováno v:
Molecular Endocrinology. 18:1346-1353
Hepatic glucose production by gluconeogenesis is the main source of glucose during fasting and contributes significantly to hyperglycemia in diabetes mellitus. Accordingly, glucose metabolism is tightly controlled by a variety of hormones including i
Autor:
Timothy J. Kieffer, Ni T. Lam, Junfeng Wang, Jeshurun Tse, Cynthia T. Luk, Jay K. Kolls, Anthony T. Cheung, Michael Bryer-Ash, Jamie T. Lewis
Publikováno v:
Molecular Endocrinology. 18:1333-1345
Leptin has been shown to improve insulin sensitivity and glucose metabolism in obese diabetic ob/ob mice, yet the mechanisms remain poorly defined. We found that 2 d of leptin treatment improved fasting but not postprandial glucose homeostasis, sugge
Autor:
Donald K. Scott, J. Jason Collier
Publikováno v:
Molecular Endocrinology. 18:1051-1063
The liver is responsible for glucose synthesis in the fasting state, and glucose uptake, storage, and utilization in the fed state. A phenotypic switch, normally initiated by insulin or glucagon, controls the transition between the two states, which
Autor:
Tahir S Pillay, Konrad Mebert, James E. Watson, Denise R. Cooper, Janet D. Sparks, Hercules Apostolatos, Charles E. Chalfant, Niketa A. Patel
Publikováno v:
Molecular Endocrinology. 18:899-911
Cells respond to external signals like insulin to alter metabolic pathways in response to varying physiological environments. Insulin stimulates the protein kinase C beta (PKCbeta) isozymes and preferentially switches the expression to PKCbetaII isoz
Autor:
Carol A. Lange
Publikováno v:
Molecular Endocrinology. 18:269-278
In classical models of nuclear steroid hormone receptor function, ligand binds receptor, heat shock proteins dissociate, and receptor dimers enter or are withheld in the nucleus and interact with coregulatory molecules to mediate changes in gene expr
Autor:
Mini P. Sajan, Michael Leitges, Mary L. Standaert, Uschi Braun, Friederike Kruse, Yoshinori Kanoh, Robert V. Farese, Atsushi Miura, Gautam Bandyopadhyay
Publikováno v:
Molecular Endocrinology. 18:373-383
Atypical protein kinase C (aPKC) isoforms have been suggested to mediate insulin effects on glucose transport in adipocytes and other cells. To more rigorously test this hypothesis, we generated mouse embryonic stem (ES) cells and ES-derived adipocyt