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Autor:
Helmut Grasberger, Marc Abramowicz, Paule LeFrancois, Samuel Refetoff, Usanee Ringkananont, Gilbert Vassart
Publikováno v:
Molecular Endocrinology. 19:1779-1791
Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. We identified a novel and unique PAX8 mutation segregating in seven affected members of a three-generations family. The
Autor:
Ronald M. Evans
Publikováno v:
Molecular Endocrinology. 19:1429-1438
In the December 1985 issue of Nature, we described the cloning of the first nuclear receptor cDNA encoding the human glucocorticoid receptor (GR) (1). In the 20 yr since that event, our field has witnessed a quantum leap by the subsequent discovery a
Publikováno v:
Molecular Endocrinology. 19:1501-1515
The association between nuclear distribution and mobility of the human glucocorticoid receptor was examined in living COS-1 cells using yellow fluorescent protein- and cyan fluorescent protein-tagged receptors. Quantitation of the nuclear distributio
Autor:
Elwood V. Jensen
Publikováno v:
Molecular Endocrinology. 19:1439-1442
In the 47 yr since the first evidence for a steroid hormone receptor was presented at an international congress to an audience of five persons, the concept of “alternative approach” has played an important role in providing new understanding. By
Autor:
Sophie Giorgetti-Peraldi, Marie-Noëlle Monthouël-Kartmann, Joseph Murdaca, Emmanuel Van Obberghen, Caroline Treins
Publikováno v:
Molecular Endocrinology. 19:1304-1317
Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of two subunits (HIF-1alpha and HIF-1beta), initially described as a mediator of adaptive responses to changes in tissue oxygenation, has been shown to be activated in an oxygen-inde
Autor:
Barton Luke Wicksteed, Christopher D. Green, L. Karl Olson, Katrina D. Linning, Diana Z. Ye, Vincent Poitout, Maria F. Pino
Publikováno v:
Molecular Endocrinology. 19:1343-1360
Chronic exposure of pancreatic beta-cells to elevated glucose reduces insulin gene promoter activity, and this is associated with diminished binding of two beta-cell-enriched transcription factors, Pdx-1 and MafA. In this study using INS-1 beta-cells
Autor:
Walter L. Miller, Ningwu Huang
Publikováno v:
Molecular Endocrinology. 19:409-420
The cholesterol side-chain cleavage enzyme, P450scc, initiates biosynthesis of all steroid hormones. Adrenal and gonadal P450scc expression requires steroidogenic factor-1 (SF1), but P450scc expression in human placental JEG-3 cells utilizes an SF1-i
Publikováno v:
Molecular Endocrinology. 19:312-326
We evaluated the signaling pathways involved in regulating vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, in response to natural and synthetic progestins in breast cancer cells. Inhibition of the phosphoinositide-3′-k
Autor:
Dimitris K. Grammatopoulos, Danijela Markovic, Edward W. Hillhouse, Michael A. Levine, Thalia Teli
Publikováno v:
Molecular Endocrinology. 19:474-490
Attenuation of CRH receptor type 1 (CRH-R1) signaling activity might involve desensitization and uncoupling of CRH-R1 from intracellular effectors. We investigated the desensitization of native CRH-R in human myometrial cells from pregnant women and
Autor:
Anthony W. Norman, June E. Bishop, Christopher J. Olivera, Laura P. Zanello, Johanna A. Huhtakangas
Publikováno v:
Molecular Endocrinology. 18:2660-2671
The steroid hormone 1α,25(OH)2-vitamin D3 (1,25D) regulates gene transcription through a nuclear receptor [vitamin D receptor (VDR)] and initiation of rapid cellular responses through a putative plasma membrane-associated receptor (VDRmem). This stu