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Autor:
Frank A. Simmen, Thomas M. Badger, Ling He, John C. Marecki, Ginette Serrero, Martin J. J. Ronis
Publikováno v:
Molecular Endocrinology. 21:2541-2550
Routine consumption of alcohol at low doses is associated with decreased risk of acquiring type 2 diabetes, whereas chronic and excessive alcohol consumption increases the risk. Although there is good epidemiologic evidence for these biphasic effects
Publikováno v:
Molecular endocrinology (Baltimore Md.)
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids
Autor:
Matthew R. Redinbo, Steven A. Kliewer, Linda B. Moore, Sompop Bencharit, Li Peng, Jillian Orans, Yu Xue
Publikováno v:
Molecular Endocrinology. 21:1028-1038
The human nuclear pregnane X receptor (PXR) responds to a wide variety of xenobiotic and endobiotic compounds, including pregnanes, progesterones, corticosterones, lithocholic acids, and 17beta-estradiol. In response to these ligands, the receptor co
Autor:
Ai Li Yeo, Peter Nowotny, Maria Nilsson, Edison T. Liu, Thomas M. Stulnig, Chin-Yo Lin, Knut R. Steffensen
Publikováno v:
Molecular Endocrinology. 21:126-137
The nuclear hormone receptors liver X receptor α (LXRα) (NR1H3) and LXRβ (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and cardiovascular disease. Adr
Publikováno v:
Molecular Endocrinology. 20:2062-2079
FSH is produced by the pituitary gonadotrope to regulate gametogenesis. Steroid hormones, including androgens, progestins, and glucocorticoids, have all been shown to stimulate expression of the FSHβ subunit in primary pituitary cells and rodent mod
Autor:
Alessandra K Cardozo, Joachim Størling, Daisy Crispim, Fernanda Ortis, Decio L. Eizirik, Thomas Mandrup-Poulsen
Publikováno v:
Molecular Endocrinology. 20:1867-1879
Cytokines, such as IL-1beta and TNF-alpha, contribute to pancreatic beta-cell death in type 1 diabetes mellitus. The transcription factor nuclear factor-kappaB (NF-kappaB) mediates cytokine-induced beta-cell apoptosis. Paradoxically, NF-kappaB has mo
Publikováno v:
Molecular Endocrinology. 20:844-856
We have identified Kruppel-like factor 7 (KLF7) as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of KLF7 in the pathogenesis of type 2 diabetes, we examined the functional roles of KLF7 in var
Autor:
Ping Liu, Lixuan Tackett, Guruprasad R. Pattar, Andrew B. Strawbridge, Guoli Chen, Padma Bhonagiri, Jeffrey S. Elmendorf
Publikováno v:
Molecular Endocrinology. 20:857-870
Evidence suggests that chromium supplementation may alleviate symptoms associated with diabetes, such as high blood glucose and lipid abnormalities, yet a molecular mechanism remains unclear. Here, we report that trivalent chromium in the chloride (C
Autor:
Michelle M. Tabb, Bruce Blumberg
Publikováno v:
Molecular Endocrinology. 20:475-482
Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that mimic or block the transcriptional activation elicited by naturally circulating steroid hormones by binding to steroid hormone receptors. For example, the Food Quality
Autor:
Jerrold M. Olefsky, Jennie L. Babendure, Juu Chin Lu, Christopher J. Hupfeld, Takeshi Imamura, Isao Usui, Hiroaki Satoh
Publikováno v:
Molecular Endocrinology. 19:2760-2768
G protein-coupled receptor kinases (GRKs) regulate seven-transmembrane receptors (7TMRs) by phosphorylating agonist-activated 7TMRs. Recently, we have reported that GRK2 can function as a negative regulator of insulin action by interfering with G pro