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Publikováno v:
Molecular Endocrinology. 25:492-502
Acute insulin resistance is common after injury, infection, and critical illness. To investigate the role of reactive oxygen species (ROS) in critical illness diabetes, we measured hepatic ROS, which rapidly increased in mouse liver. Overexpression o
Autor:
Ulrike Henrion, Martin Fraunholz, Behnam Hessabi, Robert Smail Jack, Annett Ostmann, Anke Karkour, Meike Dahlhaus, Piotr Grabarczyk, Reinhard Walther, Gabriele Wolf, Bernd Giese
Publikováno v:
Molecular Endocrinology. 24:2331-2342
The transcriptional transactivator Pax6 binds the pancreatic islet cell-specific enhancer sequence (PISCES) of the rat insulin I gene. However the human, mouse, and rat insulin gene II promoters do not contain a PISCES element. To analyze the role of
Autor:
Norihiko Mori, Yoshiyuki Soeda, Naoki Toyooka, Xu Wang, Shuji Hosoh, Syota Kagawa, Hiroshi Tsuneki, Toshiyasu Sasaoka, Teruko Uwano, Hayato Muranaka, Yoshinori Ichihara, Yusaku Takamura, Tsutomu Wada, Hisao Nishijo
Publikováno v:
Molecular Endocrinology. 24:1965-1977
Impairment of insulin and IGF-I signaling in the brain is one of the causes of dementia associated with diabetes mellitus and Alzheimer’s disease. However, the precise pathological processes are largely unknown. In the present study, we found that
Publikováno v:
Molecular Endocrinology. 24:1423-1433
Most people with type 2 diabetes (T2D) have reduced beta-cell mass, and apoptosis is a key factor for this reduction. Previously, we showed that ATF3, an adaptive-response gene, is induced by various stress signals relevant to T2D, such as high gluco
Autor:
Dongmei Wu, Alan J. Mears, Alexander Sorisky, Houssein Abdou Salem, Adèle Boudreau, Ella Atlas, Julianna J. Tomlinson, AnneMarie Gagnon, Robert J. G. Haché, Amanda Carrigan
Publikováno v:
Molecular Endocrinology. 24:104-113
Glucocorticoids are synthesized locally in adipose tissue and contribute to metabolic disease through the facilitation of adipose tissue expansion. Here we report that exposure of human primary preadipocytes to glucocorticoids increases their sensiti
Autor:
Gary L. Firestone, Shyam N. Sundar
Publikováno v:
Molecular Endocrinology. 23:1940-1947
Indole-3-carbinol and its diindole condensation product 3-3'-diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented th
Autor:
Alan J. Fox, Klaus H. Kaestner, Rana K. Gupta, Sebastian Rieck, Olga Smirnova, Peter White, Jonathan Schug, Philipp E. Scherer, Nan Gao, Mark P. Keller, Alan D. Attie, Zhao V. Wang
Publikováno v:
Molecular Endocrinology. 23:1702-1712
The inability of the ss-cell to meet the demand for insulin brought about by insulin resistance leads to type 2 diabetes. In adults, ss-cell replication is one of the mechanisms thought to cause the expansion of ss-cell mass. Efforts to treat diabete
Autor:
John McDonald, Anthony H. Taylor, Justin C. Konje, David G. Lambert, R. A. John Challiss, Paul J. Brighton, Jonathon M. Willets
Publikováno v:
Molecular Endocrinology. 23:1415-1427
Accumulating evidence highlights the importance of the endocannabinoid anandamide (AEA) as a key mediator in reproductive physiology. Current data suggest potential roles for AEA in gametogenesis, fertilization, and parturition. AEA exerts its action
Publikováno v:
Molecular Endocrinology. 23:679-688
Single chain insulins (SCIs) are single polypeptide chains in which the insulin B-chain links contiguously with the insulin A-chain via an uncleaved connecting peptide. While direct linkage of insulin Band A-chains produces SCIs with little insulin r
Autor:
Keyong Du, Jixin Ding
Publikováno v:
Molecular Endocrinology. 23:475-485
Pseudokinase TRB3 is an inducible gene whose expression is regulated by stress response and insulin and associated with insulin resistance and metabolic syndrome. In this report, we have investigated the mechanism under which insulin regulates TRB3 g