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Publikováno v:
Molecular Endocrinology. 4:108-118
The gene encoding the opioid peptide precursor preproenkephalin is expressed at high levels in the initial segment of the adult rat epididymis. Expression is localized to principal cells, the secretory epithelial cells lining the epididymal duct. Dur
Autor:
Terry F. Davies, P. Graves
Publikováno v:
Molecular Endocrinology. 4:155-161
A 0.95-kilobase (kb) thyrocyte RNA, initially detected in our 1B-6 subclone of Fisher rat thyrocytes (FRTL-5) using an oligonucleotide probe complementary to the 5' end of rat thyroglobulin (Tg) mRNA, was also detected in cultured thyrocytes of the W
Autor:
Bert W. O'Malley, Orla M. Conneely
Publikováno v:
Molecular Endocrinology. 6:1359-1361
Over the past 6 yr, we have witnessed a surprising increase in the number of known members in the steroid/thyroid/vitamin superfamily of intracellular receptors in a wide variety of species. Although the exact number of these proteins is difficult to
Publikováno v:
Molecular Endocrinology. 23:276-277
Autor:
Harald Staiger, Johanna Kuusisto, Fritz Schick, Claus D. Claussen, Karsten Müssig, Jürgen Machann, Alena Stančáková, Andreas Fritsche, Claus Thamer, Norbert Stefan, Markku Laakso, Hans-Ulrich Häring, Fausto Machicao
Publikováno v:
Molecular Endocrinology. 23:278-279
The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of beta-cell function and metabolic effects of insulin in the liver.The objective of the study was to investigate whether common genetic variation within the F
Autor:
Christopher S. Fry, Micah J. Drummond, Kyle L. Timmerman, Shaheen Dhanani, Blake B. Rasmussen, Erin L. Glynn, Melinda Sheffield-Moore, Hans C. Dreyer, Elena Volpi, Jessica Lee
Publikováno v:
Molecular Endocrinology. 24:1306-1306
Objective: Our objective was to determine whether endothelial-dependent vasodilation is an essential mechanism by which insulin stimulates human skeletal muscle protein synthesis and anabolism. Subjects: Subjects were healthy young adults (n = 14) ag
Autor:
Jerry L. Nadler, Runpei Wu, Swarup K. Chakrabarti, David A. Taylor-Fishwick, Kaiwen Ma, Craig S. Nunemaker
Publikováno v:
Molecular Endocrinology. 24:468-468
Context: Inflammation is increasingly recognized as an important contributing factor in diabetes mellitus. Lipoxygenases (LOs) produce active lipids that promote inflammatory damage by catalyzing the oxidation of linoleic and arachidonic acid, and LO
Publikováno v:
Molecular Endocrinology. 23:1936-1936
Background We recently reported on the effects of exogenous growth differentiation factor 9 (GDF9) in enhancing activin A-induced inhibin βB-subunit mRNA and inhibin B levels in human granulosa-lutein (hGL) cells by modulating key components of the
Publikováno v:
Molecular Endocrinology. 23:1519-1519
Obesity is associated with a chronic systemic low-grade inflammatory state. Markers of inflammation such as TNF-alpha are linked with increased risk for insulin resistance and type 2 diabetes. The objective of the present study was to dissect the mol
Autor:
Michael A. Derr, Peng Fang, Ron G. Rosenfeld, Vivian Hwa, I. David Schwartz, Charles Roberts, Betty D. Johnson
Publikováno v:
Molecular Endocrinology. 23:585-585
Context: Progesterone has been associated with promoting growth of uterine leiomyomas. The mechanisms involved remain unclear. Objective: In this study we investigated the activation of the AKT pathway and its downstream effectors, GSK3b and FOXO1 by