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Publikováno v:
Molecular Endocrinology. 4:990-999
Four rat insulinoma-derived cell lines were found to express only the rat insulin I gene, although an apparently normal insulin II gene was present in each cell line. This finding was reflected by the absence of insulin II and the presence of insulin
Autor:
Omar Pedro Pignataro, Mario Ascoli
Publikováno v:
Molecular Endocrinology. 4:758-765
In a recent publication we showed that addition of mouse epidermal growth factor (mEGF) to MA-10 Leydig tumor cells rapidly leads to an increase in the incorporation of [3H]inositol-derived radioactivity into an unusual lipid that was identified as p
Publikováno v:
Molecular Endocrinology. 4:583-588
Analysis of glucose transporter mRNA levels in adipose tissue from streptozotocin (STZ)-induced diabetic rats demonstrated a specific decrease (10-fold) in adipose tissue GLUT-4 mRNA with no significant effect on GLUT-1 mRNA levels. Treatment of STZ-
Autor:
Bert W. O'Malley
Publikováno v:
Molecular Endocrinology. 4:363-369
The overall molecular pathway for the action of steroid hormones has been known for the past 15 yr (1–9). Within the past 5 yr, the cDNAs for all major steroid hormones have been cloned and sequenced (10, 11). As might have been expected, they were
Publikováno v:
Molecular Endocrinology. 4:455-464
In v-mos transformed cells, glucocorticoid receptor (GR) proteins that bind hormone agonist are not efficiently retained within nuclei and redistribute to the cytoplasmic compartment. These cytoplasmic desensitized receptors cannot be reutilized and
Publikováno v:
Molecular Endocrinology. 4:402-408
The role of thyroid hormone and GH in the regulation of hypothalamic GH-releasing hormone (GRH) gene expression in the rat was examined after the induction of thyroid hormone deficiency by thyroidectomy. Thyroidectomy resulted in a time-dependent dec
Autor:
Jia Li Gu, Jonathan Whittaker, Pierre De Meyts, Bruce E. Kaplan, Graeme I. Bell, Ronald M. Shymko
Publikováno v:
Molecular Endocrinology. 4:409-416
Structure-function studies of the insulin molecule indicate that an insulin B chain domain comprising residues 22-26 is involved both in binding to the insulin receptor (INSR) and in insulin dimer formation, suggesting that this domain might also int
Autor:
Gerald A. LeBlanc, Joseph J. Morrissey, David J. Waxman, Notani Gur, Scott S. Sundseth, Prabha A. Ram, John A. Alberta
Publikováno v:
Molecular Endocrinology. 4:447-454
Oligonucleotide probes that distinguish between two closely related mRNAs encoding steroid 6 beta-hydroxylases of rat P-450 gene family CYP3A were used to individually assess their responsiveness to pituitary hormone regulation. Northern blot analysi
Publikováno v:
Molecular Endocrinology. 4:191-195
In this report we have used in situ hybridization to localize insulin-like growth factor-I (IGF-I) expression in the uterus and have examined the effects of exogenous IGF on 3H-methyl thymidine incorporation into DNA, in uterine sections in organ cul
Autor:
Barry J. Goldstein, Alana L. Dudley
Publikováno v:
Molecular Endocrinology. 4:235-244
To investigate whether alterations in the polypeptide structure of the insulin receptor might explain the heterogeneity observed in its properties between species and in different tissues, we obtained the complete primary structure of the rat liver i