Zobrazeno 101 - 110
of 304
pro vyhledávání: ''
Autor:
Olivier Goupille, Andrew Ziemiecki, Wolfgang Doppler, Claudia Soratroi, Martin Tonko, Sibylle Tonko-Geymayer, Charles H. Streuli, Reinhard Kofler, Akihiko Yoshimura
Publikováno v:
Molecular Endocrinology. 16:1680-1695
The cytokine-inducible src homology 2 (SH-2) proteins, CIS (cytokine inducible SH-2 domain protein) and SOCS3 (suppressor of cytokine signaling 3), are implicated in the negative regulation of prolactin (PRL) receptor-mediated activation of signal tr
Autor:
Nicos A. Nicola, Patrick Bertolino, Jason Corbin, Helen W. Davey, Douglas J. Hilton, Donald Metcalf, Sylvia L. Asa, Christopher J. Greenhalgh, Warren S. Alexander, Timothy E. Adams
Publikováno v:
Molecular Endocrinology. 16:1394-1406
Mice lacking suppressor of cytokine signaling-2 (SOCS-2) exhibit accelerated postnatal growth resulting in adult mice that are 1.3 to 1.5 times the size of normal mice. In this study we examined the somatotrophic pathway to determine whether the prod
Autor:
Ryoichi Takayanagi, Akiyoshi Fukamizu, Hajime Nawata, Kiminobu Goto, Masayuki Saitoh, Arihiro Tomura, Toshihiko Yanase
Publikováno v:
Molecular Endocrinology. 16:694-706
To clarify the physiological significance of the intranuclear speckled distribution, or foci formation, of liganded steroid receptors, the subnuclear distribution of green (GFP), yellow (YFP), and cyan (CFP) fluorescent protein-tagged receptors and c
Autor:
Rolf Vajna, Cornelia Gissel, Neil Smyth, Jürgen Hescheler, Margit Henry, Toni Schneider, Marina Mikhna, Marco Weiergräber, Alexey Pereverzev
Publikováno v:
Molecular Endocrinology. 16:884-895
Multiple types of voltage-activated Ca(2+) channels (T, L, N, P, Q, R type) coordinate Ca(2+)-dependent processes in neurons and neuroendocrine cells. Expressional and functional data have suggested a role for Ca(v)2.3 Ca(2+) channels in endocrine pr
Publikováno v:
Molecular Endocrinology. 15:1880-1890
The hypothalamo-pituitary-adrenal (HPA) axis maintains a homeostatic response to stress, infection, or neoplasia. Inflammatory cytokines, including leukemia inhibitory factor (LIF), stimulate the HPA axis either directly at the pituitary corticotroph
Publikováno v:
Molecular Endocrinology. 15:1864-1869
Insulin resistance, the failure to respond to normal circulating concentrations of insulin, is a common state associated with obesity, aging, and a sedentary lifestyle. Compelling evidence implicates TNFα as the cause and link between obesity and in
Publikováno v:
Molecular Endocrinology. 15:1993-2009
Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize that the hormonal milieu that is present during pregnancy results in persistent changes in the pattern of gene expre
Publikováno v:
Molecular Endocrinology. 15:1929-1940
Steroid hormone receptors and signal transducers and activators of transcription (STAT) factors constitute two distinct families of transcription factors activated by different signaling pathways. In previous reports, cross-talk between STAT5 and sev
Publikováno v:
Molecular Endocrinology. 15:1768-1780
PTP1B is a protein tyrosine phosphatase that negatively regulates insulin sensitivity by dephosphorylating the insulin receptor. Akt is a ser/thr kinase effector of insulin signaling that phosphorylates substrates at the consensus motif RXRXXS/T. Int
Autor:
Maribel Rios, Joseph Kelly, Guoping Fan, Rudolf Jaenisch, Brian Bates, Ronald M. Lechan, Ralf Kuehn, Csaba Fekete
Publikováno v:
Molecular Endocrinology. 15:1748-1757
Brain-derived neurotrophic factor has been associated previously with the regulation of food intake. To help elucidate the role of this neurotrophin in weight regulation, we have generated conditional mutants in which brain-derived neurotrophic facto