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Autor:
Jacques Emile Dumont, Bernard Corvilain, Ling Jin, Catherine Ledent, Paul Van Hummelen, Hortensia Mircescu, Jean-Christophe Goffard
Publikováno v:
Molecular Endocrinology. 18:194-213
Mutations of the TSH receptor leading to constitutive activation of the cAMP cascade are responsible for the development of hot nodules, if arising in a somatic cell, and nonautoimmune hyperthyroidism, when occurring in a germinal cell. An animal mod
Autor:
Winnie Eskild, Gerd H. G. Moe-Behrens, Francesca Gioia Klinger, Massimo De Felici, Tom Grotmol, Trine B. Haugen
Publikováno v:
Molecular Endocrinology. 17:2630-2638
Testicular tumors in humans are reported to be significantly increasing in incidence. Embryo exposure to environmental estrogens has been proposed as one of the possible underlying causes. In mice, genetic, immunological, and experimental evidence su
Autor:
April A. Sullivan, Carl S. Thummel
Publikováno v:
Molecular Endocrinology. 17:2125-2137
The recent completion of the Drosophila genome sequence revealed 21 members of the nuclear receptor superfamily. Many of these genes are transcriptionally regulated by the steroid hormone ecdysone and play a role during the onset of metamorphosis, in
Autor:
Minoru Asada, Yoel Sadovsky, Louis J. Muglia, Yoshihiko Nagai, Thomas J. Hudson, Kathleen E. Bethin, Robert Sladek
Publikováno v:
Molecular Endocrinology. 17:1454-1469
Improved care of infants born prematurely has increased their survival. However, the incidence of preterm labor has not changed. To understand the processes involved in preterm labor, we used oligonucleotide microarrays to study gene expression in mu
Autor:
Harumi Hattori, Koji Yoshimura, Cydney C. Brooks, Eleonora Presman, Yukio Fujisawa, Nozomi Katayama, Shigeya Kakimoto, Isao Kaieda, Paul F. Pilch, Hideaki Tojo
Publikováno v:
Molecular Endocrinology. 17:1216-1229
Insulin stimulates translocation of glucose transporter isoform type 4 (GLUT4) and the insulin-responsive aminopeptidase (IRAP) from an intracellular storage pool to the plasma membrane in muscle and fat cells. A role for the cytoskeleton in insulin
Autor:
Julie M. Hall, Kenneth S. Korach
Publikováno v:
Molecular Endocrinology. 17:792-803
Recent clinical studies estimate that 60-70% of human ovarian and breast cancers overexpress the estrogen receptor (ER). However, despite the established mitogenic effects of estrogen in these tumors, proliferative markers of hormone action are limit
Publikováno v:
Molecular Endocrinology. 17:472-486
The insulin receptor substrate 1 (IRS-1) can translocate to the nuclei and nucleoli of several types of cells. Nuclear translocation can be induced by an activated insulin-like growth factor 1 receptor (IGF-IR), and by certain oncogenes, such as the
Autor:
Mathias Z. Strowski, Jill K. Fisher, Bei B. Zhang, Howard Y. Chen, Myrna E. Trumbauer, Martin Köhler, Hilary A. Wilkinson, Shobhna Gopal-Truter, Zhihua Li, James M. Schaeffer, Allan D. Blake, Deborah Szalkowski
Publikováno v:
Molecular Endocrinology. 17:93-106
Somatostatin (SRIF) regulates pancreatic insulin and glucagon secretion. In the present study we describe the generation of SRIF receptor subtype 5 knockout (sst(5) KO) mice to examine the role of SRIF receptor subtypes (sst) in regulating insulin se
Autor:
Meng Chun Hu, Nai Chi Hsu, Hsueh-Ping Chu, Bon Chu Chung, Chi-Kuang Leo Wang, Noomen Ben El Hadj, Chin I. Pai
Publikováno v:
Molecular Endocrinology. 16:1943-1950
Steroid deficiencies are diseases affecting salt levels, sugar levels, and sexual differentiation. To study steroid deficiency in more detail, we used a gene-targeting technique to insert a neo gene into the first exon to disrupt Cyp11a1, the first g
Autor:
Donald B. DeFranco
Publikováno v:
Molecular Endocrinology. 16:1449-1455
Steroid hormone receptors exert much of their effects on cellular physiology through regulating the rate of transcription from unique target genes. Much has been learned about the actions of steroid hormone receptors at regulated promoters through mo