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Autor:
Julie M. Hall, Kenneth S. Korach
Publikováno v:
Molecular Endocrinology. 17:792-803
Recent clinical studies estimate that 60-70% of human ovarian and breast cancers overexpress the estrogen receptor (ER). However, despite the established mitogenic effects of estrogen in these tumors, proliferative markers of hormone action are limit
Autor:
Ryoichi Takayanagi, Akiyoshi Fukamizu, Hajime Nawata, Kiminobu Goto, Masayuki Saitoh, Arihiro Tomura, Toshihiko Yanase
Publikováno v:
Molecular Endocrinology. 16:694-706
To clarify the physiological significance of the intranuclear speckled distribution, or foci formation, of liganded steroid receptors, the subnuclear distribution of green (GFP), yellow (YFP), and cyan (CFP) fluorescent protein-tagged receptors and c
Publikováno v:
Molecular Endocrinology. 15:1880-1890
The hypothalamo-pituitary-adrenal (HPA) axis maintains a homeostatic response to stress, infection, or neoplasia. Inflammatory cytokines, including leukemia inhibitory factor (LIF), stimulate the HPA axis either directly at the pituitary corticotroph
Autor:
Ester Coronado-Heinsohn, Jennifer L. Gooch, Adrian V. Lee, Douglas Yee, C K Osborne, Susan G. Hilsenbeck, James G. Jackson
Publikováno v:
Molecular Endocrinology. 13:787-796
Cross-talk between insulin-like growth factor (IGF)- and estrogen receptor (ER)-signaling pathways results in synergistic growth. We show here that estrogen enhances IGF signaling by inducing expression of three key IGF-regulatory molecules, the type
Autor:
Herbert Y. Gaisano, Michael B. Wheeler, Youhou Kang, William S. Trimble, Laura Sheu, Xiaohang Huang, Gergely L. Lukacs
Publikováno v:
Molecular Endocrinology. 12:1060-1070
We and others have previously shown that insulin-secreting cells of the pancreas express high levels of SNAP-25 (synaptosomal-associated protein of 25 kDa), a 206-amino acid t-SNARE (target soluble N-ethylmaleimide-sensitive factor attachment protein
Publikováno v:
Molecular Endocrinology. 12:568-579
Steroidal (ICI 182, 780) and nonsteroidal hydroxytamoxifen (OH-Tam) antiestrogens inhibit growth factor-mitogenic activity in MCF 7 estrogen receptor-positive human breast cancer cells. Cell inhibition is correlated with an increase in membrane prote
Publikováno v:
Molecular Endocrinology. 11:997-1007
The growth-promoting activity of GH, the principal hormonal determinant of body size, is mediated by insulin-like growth factor I (IGF-I). Most of the IGF-I in plasma circulates in a 150-kDa complex that contains IGF-binding protein-3 (IGFBP-3) and a
Autor:
Marie Pierre Gaub, Huib A.P. Pols, Janet L. Stein, J.P.T.M. van Leeuwen, Gary S. Stein, H. F. Deluca, J. Prahl, Jan C. Birkenhäger, A. Staal, A. J. Van Wijnen, J. B. Lian
Publikováno v:
Scopus-Elsevier
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
Molecular Endocrinology, 10(11), 1444-1456. The Endocrine Society
The 1 alpha,25-dihydroxyvitamin D3 (VD3)-dependent stimulation of osteocalcin (OC) and osteopontin (OP) gene transcription in bone tissue is mediated by interactions of trans-activating factors with distinct VD3-responsive elements (VDREs). Sequence
Publikováno v:
Molecular Endocrinology. 10:713-722
Bone loss observed in postmenopausal women is clearly associated with a decrease in estrogen levels. Interleukin 6 (IL-6), a multifunctional cytokine involved in osteoclast differentiation, is secreted by osteoblasts and appears to be a key molecule
Autor:
Joe S. Mymryk, Trevor K. Archer
Publikováno v:
Molecular Endocrinology. 9:1825-1834
Steroid hormones act via a group of high affinity receptors that regulate transcription by binding to hormone response elements located in the promoters of hormone-inducible genes. Our understanding of these processes has been greatly enhanced by the